Dr Adrien Hallou

University of Cambridge

University departments
Department of Physics
University institutes
Wellcome Trust CRUK Gurdon Institute
Wellcome Trust MRC Cambridge Stem Cell Institute

Position: Herchel Smith Research Fellow - Fellow of Darwin College
Personal home page: https://www.tcm.phy.cam.ac.uk/profiles/ah691/

PubMed journal articles - click here

Dr Adrien Hallou is pleased to consider applications from prospective PhD students.

Research description

Initially trained as a physicist and a chemist at the Ecole Normale Supérieure (Paris, France), I developed my interest for quantitative approaches of biological systems during my MPhil and PhD in Biophysics at the University of Cambridge. I am now a Research Fellow at Darwin College and a Herchel Smith Research Fellow in the group of Professor Benjamin Simons, where my work combines theoretical methods from statistical and soft matter physics with wet lab biology experiments to understand the role of cellular heterogeneity in cell fate decision, pattern formation and tissue function during development, homeostasis and tumorogenesis.

Methods and technologies
Atomic force microscopy
Cell culture
Computational modelling
Confocal microscopy
Fluorescence microscopy
Gene expression profiling
Imaging
Immunohistochemistry
In vivo modelling
Microscopy
Statistical analysis
Tumour type interests
Colorectal
Leukemia
No direct clinical relevance
Oesophagus
Small intestine
Stomach
Keywords
Mechanobiology
Spatial Transcriptomics
Modelling
Stem cells
Homeostasis
Regeneration
Tumour growth
Tumour heterogeneity
Collective invasion
Metastasis
ah691
Recent publications:
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Key publications

Grockowiak, E., Korn, C., Rak, J., Lysenko, V., Hallou, A., et al. Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms. Nature Cancer (2023).
https://doi.org/10.1038/s43018-023-00607-x

L. Rosalia*, A. Hallou*, L. Cochrane and T. Savin. A magnetically actuated, optically sensed tensile testing method for mechanical characterization of soft biological tissues, Science Advances 9(2): eade2522 (2023).
https://doi.org/10.1126/sciadv.ade2522

A. Hallou*, H.G. Yevick*, B. Dumitrascu and V. Uhlmann. Deep learning for bioimage analysis in developmental biology, Development 148(18) dev199616 (2021).
https://journals.biologists.com/dev/article/148/18/dev199616/272084/Deep...

J. McGinn, A. Hallou, S. Han et al. A biomechanical switch regulates the transition towards homeostasis in oesophageal epithelium. Nature Cell Biology (2021).
https://doi.org/10.1038/s41556-021-00679-w

A. Hallou* & T. Brunet. On growth and force: mechanical forces in development. Development 147 (4): dev187302 (2020).
https://dev.biologists.org/content/147/4/dev187302.article-info

P. Recho*, A. Hallou* & E. Hannezo*. Theory of mechanochemical patterning in biphasic biological tissues. PNAS 116 (12): 5344-5349 (2019).
https://doi.org/10.1073/pnas.1813255116

A. Hallou *, J. Jennings and A.J Kabla. Tumour heterogeneity promotes collective invasion and cancer metastatic dissemination. Royal Society Open Science 4, 161007 (2017).
http://rsos.royalsocietypublishing.org/content/4/8/161007

(*=first author or co-first author)