David performs forward genetic screens to uncover cancer genes and pathways and leads a programme to decode the genomes of several mouse strains. He also leads the Mouse Genomes Project and the Mouse Genetics Project. The Mouse Genomes Project is sequencing and assembling mouse strain genomes while the Mouse Genetics Project is part of the International Mouse Phenotyping Consortium and aims to generate phenotyping data for over 200 genetically modified mouse lines per year to gain a better understanding of mammalian gene function.