Our long-term aim is to understand the interplay between the myriad pathways involved in the pathogenesis of multiple myeloma so that these can be targeted for therapeutic benefit. The initial focus of our research is the role of aberrant RNA processing in myeloma biology, based on findings from an initial sequencing of the myeloma genome (Chapman et al. Nature 2011) and subsequent myeloma genome sequencing projects. We are investigating not only the molecular mechanisms involved, but also the affected RNA targets, as these will identify nodes of intersection with known pathways as well as novel pathways in myeloma biology. Drawing on a wide experience in both molecular biology and bioinformatics, as well as extensive local expertise, we are applying a multidisciplinary approach, involving a number of cutting edge techniques. These will include molecular, cellular, genetic, structural, and genomic approaches and our work benefits from established local and international collaborations.