Dr Marc Fiedler

MRC Laboratory of Molecular Biology

NHS or other affiliations: 
Protein and Nucleic Acid Chemistry (PNAC)

Position: Senior Research Associate
Personal home page: http://www2.mrc-lmb.cam.ac.uk/group-leaders/a-to-g/mariann-bienz/

PubMed journal articles - click here

Dr Marc Fiedler is pleased to consider applications from prospective PhD students.

Research description: 

Structural and functional analysis of Wnt pathway components

Research Programme or Virtual Institute: 
Fundamental Biology of Cancer
Methods and technologies: 
Cell culture
Confocal microscopy
Fluorescence microscopy
Protein biochemistry
Protein purification
Recombinant protein expression
X-ray crystallography
Tumour type interests: 
Colorectal
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Recent publications:
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Key publications: 

Fiedler M, Sánchez-Barrena M, Nekrasov M, Mieszczanek J, Rybin V, Müller J, Evans P and Bienz M., (2008), Decoding of Methylated Histone H3 Tail by the Pygo-BCL9 Wnt Signaling Complex, Mol Cell, Vol. 30, Issue 4, Pages 507-518 Fiedler M., Mendoza-Topaz C., Rutherford T.J., Mieszczanek J., Bienz M., Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating ?-catenin, (2011), Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1937-42.
Fiedler M, Graeb M, Mieszczanek J, Rutherford TJ, Johnson CM, Bienz M (2015), An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP. Elife. 2015 Aug 27