Professor Margaret Ashcroft

University of Cambridge

University departments
Department of Medicine

Position: Professor
Personal home page: http://www.med.cam.ac.uk/ashcroft/

PubMed journal articles - click here

Professor Margaret Ashcroft is pleased to consider applications from prospective PhD students.

Research description

Our research focuses on understanding the molecular mechanisms regulating the cellular response to low oxygen (hypoxia). Hypoxia is a key feature associated with the pathology of many diseases, including cancer.

The main goals of the Ashcroft laboratory are to:
1) Evaluate known and novel molecular mechanisms of hypoxia signalling with particular focus on the regulation of hypoxia inducible factors (HIFs).
2) Investigate the key cellular mechanisms underlying oxygen-sensing and hypoxia responses using model systems and elucidate how these are mechanistically linked to disease.
3) Identify and develop therapeutic strategies to exploit hypoxia (HIF) biology in cancer, and other diseases.

Research Programme or Virtual Institute
Urological Malignancies Virtual Institute
Secondary Programme
Early Cancer Institute
Methods and technologies
Bioinformatics
Cell culture
Confocal microscopy
DNA sequencing
Fluorescence microscopy
Gene expression profiling
Imaging
Immunohistochemistry
Metabolomics
Microscopy
Model organisms
PCR
Protein biochemistry
Proteomics
RNAi
Tumour type interests
Brain and central nervous system
Breast
Colorectal
Kidney
Prostate
Keywords
Hypoxia
HIF transcription factor
oxygen sensing
metabolism
mitochondria
small molecule targeted agents
renal cell carcinoma
ma630
Recent publications:
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