Dr Mairi Louise
Position: Post Doctoral Research Associate
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PubMed journal articles - click here
I study the processes involved in DNA replication in eukaryotes, including the mechanism of priming by the replicative primase and the assembly of the replisome. We employ various techniques, including structural biology and biophysics.
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A Ctf4 trimer couples the CMG helicase to DNA polymerase ? in the eukaryotic replisome: Simon AC, Zhou JC, Perera RL, van Deursen F, Evrin C, Ivanova ME, Kilkenny ML, Renault L, Kjaer S, Matak-Vinkovi? D, et al., Nature 510(7504):293-297 12 Jun 2014. Structures of human primase reveal design of nucleotide elongation site and mode of Pol ? tethering: Kilkenny ML, Longo MA, Perera RL, Pellegrini L, Proc Natl Acad Sci U S A 110(40):15961-15966 01 Oct 2013. Mechanism for priming DNA synthesis by yeast DNA Polymerase ?: Perera RL, Torella R, Klinge S, Kilkenny ML, Maman JD, Pellegrini L, eLife 2013(2) 2013 A conserved motif in the C-terminal tail of DNA polymerase ? tethers primase to the eukaryotic replisome: Kilkenny ML, De Piccoli G, Perera RL, Labib K, Pellegrini L, J Biol Chem 287(28):23740-23747 06 Jul 2012
