Clinical Research Fellowships for 2018

Information for clinical student applicants for 2018

Full details about the Clinical Research Fellowships available for 2018 are listed below. Applications for these Fellowships must be made via the University's Job Opportunities website. The deadline for applications is 30 November 2017.

The CRUK Cambridge Centre is a dynamic collaboration of academic researchers, clinicians, and the pharmaceutical and biotech industries based in the Cambridge area. We combine world-class science and technology with excellent patient care to pioneer new ways to prevent, detect and treat cancer. By working together across different disciplines, we are breaking down the barriers between the laboratory and the clinic, enabling patients to benefit from the latest innovations in cancer science.

More than 600 laboratory researchers and physicians are united through a 12 programme structure that brings together investigators working on: Aerodigestive, Breast, Haematological, Brain, Ovarian, Paediatric, Pancreatic and Urological cancers. An additional four programmes focus on: ‘Cancer Imaging’ to promote our world-leading expertise in laboratory and clinical imaging research; ‘Cell and Molecular Biology’, to engage our colleagues working in all aspects of biology relevant to cancer; ‘Early Detection’ to support this special area of research emphasis in our CRUK Major Centre; and ‘Onco-Innovation’ to provide a collaboration point for our colleagues in the pharmaceutical industry (e.g., AstraZeneca, Medimmune) as well as members from University departments in the physical sciences.  

This extensive research effort is supported by a state-of-the-art research environment that includes:

  • World-class research facilities for basic and clinical research
  • Nationally and internationally recognised centres of excellence – the Cambridge Centre is one of only two CRUK Major Centres, and Cambridge is hub for Early Detection and Precision Medicine.
  • Outstanding opportunities for translational research – the wealth of basic research across the Centre is fuelling major efforts to translate fundamental scientific discoveries to benefit patients with cancer.  

One of the main principles of the Centre is the open exchange of scientific knowledge and skills across the many disciplines involved in cancer science, creating a culture of continuous learning and development for all members. In keeping with this aim, the Centre also supports a broad programme of formal education and training designed to nurture the next generation of cancer researchers and clinicians. We will fund up to 4 Clinical Research Training Fellowships for 2018 covering an exciting range of studies, mapped onto a subset of our Programmes, as listed below under PhD projects available for 2018.

By being part of the CRUK Cambridge Centre, clnical students will also have the opportunity to attend a number of lecture series, workshops and meetings aimed at facilitating and strengthening collaborations between complementary disciplines and across different departments and institutes.

We invite applications from UK, EU and non-EU students who have completed their clinical training. Please ensure you meet the entrance requirements and follow the application processes detailed below.

Applications for the  CRUK Cambridge Centre Clinical Research Training Fellowships must be made via the University of Cambridge Job Opportunities website

The application deadline is 30 November 2017.

Clinical student applicants
The Clinical Research Fellowship scheme forms part of the CRUK Cambridge Centre’s ‘Integrated Academic Training Programme’, as defined by the National Institute for Health Research (NIHR). This means that training is tailored to equip translational scientists with the skills and experience they need to progress in their combined research and clinical careers.

CRUK Cambridge Centre Clinical Research Fellowships are financed by Cancer Research UK and provide clinicians with funds to cover a full-time 3 year PhD degree. This includes a clinical salary and University Composition Fees at the ‘UK/EU’ rate (*overseas applicants may apply, and will usually be eligible to apply for the reduced staff University Composition Fee (UCF), which is one third of either the full- or part-time Home Student UCF, for all qualifying students, irrespective of whether they are classified as UK, EU or Overseas. Successful international applicants would be required to apply for the reduced staff UCF via their host department, and if they are not eligible they may be required to self-fund the cost difference between Overseas and UK/EU fees; this is approximately £18,408 per year for 3 years).

Our Clinical Research Fellows are registered as students of the University of Cambridge and may also hold an honorary contract with Cambridge University Hospitals NHS Foundation Trust. This will require registration with the GMC so applicants should check their eligibility here.

CRUK Cambridge Centre Clinical Research Fellowships are based in a variety of laboratories across the CRUK Cambridge Centre, such as University of Cambridge Departments, various sites on the Cambridge Biomedical Campus and well-known research institutes within Cambridge.

By being part of the CRUK Cambridge Centre, Clinical Research Fellows will have the potential to work with outstanding clinicians and academics; develop collaborations with pharmaceutical and biotech companies; have access to state-of-the art research facilities; and the opportunity to attend numerous lecture series, workshops and meetings aimed at facilitating and strengthening collaborations between different disciplines and across different departments and institutes. 

Application and selection process
We invite applications from highly motivated and talented clinicians (UK, EU and non-EU* see above condition for overseas applicants) who have the potential to pursue a career as an academic clinician.

Submitting your application

To apply online for a Clinical Research Fellowship and to view further information about the application process, please visit the University's Job Opportunities page.

This will take you to the listing on the University’s Job Opportunities pages. There you will need to click on the 'Apply online' button and register an account with the University's Web Recruitment System (if you have not already) and log in before completing the online application form.

Please ensure that you upload a CV and statement of interest (this should include up to two project choices - a first and second choice - from those listed below as well as confirming your eligibility to practice) in the Upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

The application deadline is 30 November 2017

PhD projects available for 2018
Applications are welcomed in 4 of our programmes: Aerodigestive Cancers, Breast Cancer, Early Detection and Pancreatic Cancer.

The projects offered within each of these programmes are outlined below. Applicants will chose their preferred Programme and short-listed candidates will be invited to interview, at which their career intentions and preferred PhD project will be discussed. Successful applicants will subsequently develop a detailed project proposal with their chosen Programme and host laboratory, prior to applying for admission as a PhD student to the University of Cambridge. Applicants can select up to two projects (a first and second choice) when applying. Each of the project titles below links to a pdf giving an outline of the project. For further information you are encouraged to study the website of the Supervisor, and Second supervisor where applicable.

Aerodigestive Cancers Programme
Correlating genotype and phenotype of differentiated colorectal cancer cells
Supervisor: Simon Buczacki
Laboratory location: Stem Cell Institute

Mechanisms underpinning the link between COPD/emphysema and lung cancer
Supervisor: Dr Frank McCaughan
Second supervisors: Dr Ravi Mahadeva, Dr Robert Rintoul
Laboratory location: Department of Biochemistry; Department of Medicine

Normalisation of APC expression in colon cancer
Supervisor: Marc de la Roche
Second supervisor: Simon Buczacki
Laboratory location: Department of Biochemistry

Subversion of quiescence mechanisms in lung squamous cell cancers
Supervisor: Emma Rawlins
Laboratory location: The Gurdon Institute

Targeting PPP1R15 in mesothelioma
Suervisor: Professor Stefan Marciniak
Second supervisor: Dr Joseph Chambers
Laboratory location: Cambridge Institute for Medical Research

Breast Cancer Programme
Neo-RT - a new study of pre-operative breast IMRT in patients receiving neo-adjuvant hormonal treatment 
Supervisor: Charlotte Coles
Second supervisor: Carlos Caldas
Laboratory location: CRUK Cambridge Institute

Early Detection Programme
Computational pathology of cytosponge samples for the early detection of oesophageal cancer
Supervisor: Florian Markowetz
Second supervisor: Rebecca Fitzgerald
Laboratory location: CRUK Cambridge Institute

Developing non-invasive point-of-care tests for prostate cancer for earlier detection of aggressive disease
Supervisor: Charlie Massie
Second supervisor: Andrew Flewitt
Laboratory location: Hutchison-MRC Research Centre

Pancreatic Cancer Programme
Dissecting the tumour microenvironment of pancreatic cancer
Supervisor: Martin Miller
Second supervisor: Bristi Basu
Laboratory location: CRUK Cambridge Institute 

Interactions between genomic instability and the immune response during pancreatic cancer evolution 
Supervisor: Ashok Venkitaraman 
Laboratory location: MRC Cancer Unit 

What limits immunotherapy as treatment for pancreatic cancer?
Supervisor: Duncan Jodrell
Second supervisor: James Thaventhiran
Laboratory location: CRUK Cambridge Institute

Shortlisted applicants will be invited to an interview at the Cancer Research UK Cambridge Institute wc 22 January 2018.

You will be interviewed by a panel of Principal Investigators from the CRUK Cambridge Centre and you will be given the opportunity to visit the relevant department(s) or institute(s) for your selected project. We strongly encourage informal interaction between short-listed candidates and the Principal Investigators and their laboratories before the formal interview.

Following your interview you will be informed of the outcome via email.

If you are successful in securing a Clinical Research Training Fellowship, you will receive a letter of offer informing you that you will now need to apply formally for admission as a PhD student to the University of Cambridge. PhD applications are made using an online Graduate Student Application Form (GRADSAF) and all relevant application details will be provided in the letter of offer. Full information about how to apply for a PhD place at the University can be found on the University’s Graduate Admissions website.

Key dates
• The deadline for applications is 30 November 2017
• Applicants will be notified of the outcome of their application by early January 2018.
• Shortlisted applicants will be invited for interview wc 22 January 2018.
• Applicants will be notified of the outcome at the beginning of February 2018 and successful applicants will receive a formal letter of offer by mid-February 2018