Tue 19 Oct 11:00: LMB Seminar: Biomolecular condensates and their implications for physiology and disease

LMB Seminar: Biomolecular condensates and their implications for physiology and disease

Cells organize many of their biochemical reactions by formation and dissolution of non-membrane-bound compartments. Recent experiments show that one common mechanism for such biochemical organization is phase separation of disordered proteins to form liquid-like compartments. These compartments can subsequently harden to form compartments with new material properties such as gels and glasses. These compartments can be described by principles elucidated from condensed-matter physics and are therefore termed biomolecular condensates. I will discuss potential roles of phase separation in organization and robustness of cellular biochemistry and the role of aberrant phase separation in disease.

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