Cells organize many of their biochemical reactions by formation and dissolution of non-membrane-bound compartments. Recent experiments show that one common mechanism for such biochemical organization is phase separation of disordered proteins to form liquid-like compartments. These compartments can subsequently harden to form compartments with new material properties such as gels and glasses. These compartments can be described by principles elucidated from condensed-matter physics and are therefore termed biomolecular condensates. I will discuss potential roles of phase separation in organization and robustness of cellular biochemistry and the role of aberrant phase separation in disease.
- Speaker: Tony Hyman, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
- Tuesday 19 October 2021, 11:00-12:00
- Venue: Webinar - https://zoom.us/j/92425532683?pwd=bXhPUkh0dm8xRlVmUkthREQwUnc4UT09.
- Series: MRC LMB Seminar list; organiser: Scientific Meetings Co-ordinator.