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  1. Dr Duncan Brian

  2. Dr Alejandra Bruna

    We aimed to study the effects of the TGF-beta pathway in breast cancer stem cell (BCSC) regulation. To define a role of the TGF-beta pathway in the regulation of human BCSCs, we have analyzed a panel of breast cancer cell lines that represent the...

  3. Dr Joanna Baxter

    The Cambridge Blood and Stem Cell Biobank is a facility of over 6000 viable and nucleic acid samples, the majority from patients with haematological malignancy and clonal blood cell disorders; and the remainder, around 20%, from normal individuals,...

  4. Professor Jean Abraham

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  5. Professor Duncan Jodrell

    I endeavour to integrate and optimise the pre-clinical development and science-led clinical application of novel therapies and novel therapeutic combinations, including first into man (phase I) and associated studies.  My research goal is to identify...

  6. Dr Oscar M Rueda

    Development of statistical methods and models for the analysis and integration of breast cancer high-throughput data: detection of alterations in DNA copy number and their influence in mRNA expression and survival, in order to obtain predictive markers....

  7. Dr Richard Baird

    Early phase clinical trials, including expertise in: ...

  8. Dr Robin Hesketh

    I am based in the Biochemistry Department and work on several cancer related projects, primarily in collaboration with Jim Metcalfe, Kevin Brindle and Doug Easton. These fall into four areas (1) Development of anti-angiogenic gene therapy, (2) Studies...

  9. Dr Brian Hendrich

  10. Dr Brian Ferguson

  11. Professor Brian Huntly

    Our aim is to further characterise the molecular and cellular biology of cancer stem cells and to compare and contrast these to normal stem cells. To do so, we utilise malignant and normal haematopoiesis as our model system and use complementary genetic...

  12. Professor Alan Warren

    Our long-term goal is to elucidate the molecular mechanisms of ribosome assembly in eukaryotic cells and to understand how defects in this process cause bone marrow failure and cancer predisposition. Assembly of the two subunits of the ribosome,...

  13. Dr Alex Cagan

    ... our bodies as we age and their consequences for health.  Evolution is often considered  to be an almost imperceptibly slow process. ... to describe and understand these processes of somatic evolution. In particular I develop and apply methods to study somatic ...

  14. Dr Christopher Jones

    ... also interested in the study of radiotherapy-related genomic evolution. ...

  15. Dr David Fairen-Jimenez

    Our research concerns the study of the molecular mechanisms that control adsorption processes in porous materials. We are particularly interested in drug delivery systems, where nanotechnology has a fundamental impact to revolutionise cancer diagnosis...

  16. Professor David Glover

    Our laboratory studies the regulation of progression through mitosis and meiosis in animal cells. The high degree of evolutionary conservation of these regulatory mechanisms means that findings in model organisms are readily applicable to human cells....

  17. Professor Elizabeth Murchison

    Elizabeth Murchison studies the genetics and evolution of clonally transmissible cancers. Transmissible cancers are unusual ... Cancer Group, which particularly studies the genetics and evolution of transmissible cancers in dogs and Tasmanian devils. ...

  18. Dr Geoff Macintyre

    ... focus on modelling tumour heterogeneity and subclonal tumour evolution. ...

  19. Professor George Vassiliou

    ... Stem Cell Institutes. My group is studying the pre-clinical evolution, pathogenesis and treatment of haematological malignancies with a ...

  20. Dr Isidro Cortes Ciriano

    ... inference of the molecular mechanisms underlying cancer evolution, early detection of cancer, and the identification of the somatic ...

  21. Dr Inigo Martincorena

    ... I investigate these early changes by studying somatic evolution in normal and precancerous tissues. I also work on adapting ...

  22. Dr Adrien Hallou

    ... lab biology experiments to understand the role of cellular heterogeneity in cell fate decision, pattern formation and tissue function ...

  23. Professor Evis Sala

    ... methods for evaluation of spatial and temporal tumour heterogeneity with genomics, proteomics and metabolomics. The integration of ... data will be essential for unravelling tumour heterogeneity and making real-time clinical decisions for patients. I am one ...

  24. Professor Grant Stewart

    Professor Stewart is an academic surgeon at the University of Cambridge, with a focus on developing and promoting surgery related clinical trials and translational research. Grant has a specific interest in optimising management of patients with...

  25. Dr Hanna Najgebauer

    ... models based on their clinical relevance and covered genomic heterogeneity observed in primary disease. ...

  26. Dr Joo-Hyeon Lee

    ... regeneration. We are also interested in defining cellular heterogeneity and plasticity during this process. Elucidating the normal ...

  27. Dr Lucy Yates

    ... to uncover the genomic basis of breast cancer, intra-tumour heterogeneity and the evolutionary patterns underlying metastasis. My current ...

  28. Professor Paul Pharoah

    ... how germline genetic variation influences disease heterogeneity and heterogeneity in the clinical outcomes of cancer. ...

  29. Mr Richard Mair

    ... this interaction. I am interested in understanding the heterogeneity present within glioblastoma and how this can be understood ...