Programmes overview

The Centre supports a broad range of cross-cutting programmes including large population studies of cancer risk, developing novel imaging techniques to detect and monitor cancer, and understanding what goes wrong inside tumour cells. Academic and clinical researchers from different University departments and research institutes are encouraged to collaborate on research projects with the aim of stimulating new approaches and novel research methods for tackling the challenges of cancer science.

The Centre supports 12 major interdisciplinary research programmes...
Advanced Cancer Imaging Programme
Advanced Cancer Imaging
The CRUK Cambridge Centre is developing novel technologies to look inside cancer cells. Imaging plays an increasingly important role in our translational priorities of drug development, through ‘first-in-man’ experimental medicine studies, with parallel studies in pre-clinical models, and in early detection. The aim of advancing imaging technologies and applications draws on Cambridge’s strengths...
Programme Contacts:
Kevin Brindle
Evis Sala
Kelly Holmes
Elisabeth Crowe
Breast Cancer Programme
Breast Cancer
Every year around 50,000 new cases of breast cancer are diagnosed in the UK. Five out of six women with breast cancer in England and Wales survive for at least five years; however, around 1,000 UK women still die of breast cancer every month. Breast cancer research in Cambridge is aiming to increase the survival rate through large-scale population studies to determine which genes are responsible...
Programme Contacts:
Jean Abraham
Jason Carroll
Joanna Worley
Cancer Immunology
The Cancer Immunology Programme aims to build on Cambridge's world-leading expertise in normal and cancer immunology, e.g., cell-membrane-proteome profiling, to identify novel haematological and non-haematological (brain/ovary/lung) cancer targets for cell therapies. We will develop novel CAR-T and CAR-NK treatments and optimise these through preclinical models and studies of T-cell exhaustion,...
Programme Contacts:
Cell and Molecular Biology Programme
Cell and Molecular Biology
A major research focus across the CRUK Cambridge Centre is furthering our understanding of the molecular and cellular structure of pre-cancerous cells so that patients at risk of developing cancer are identified earlier. Researchers and clinicians work together to apply scientific discoveries to the clinic, through finding new ways of detecting cancer as early as possible and developing...
Programme Contacts:
Gerard Evan
David Adams
Rhys Grant
Early Detection Programme
Early Detection
Early diagnosis and intervention is a key priority and addressing this requires a unique combination of genetic epidemiology, coupled with strengths in genomics, epithelial biology, imaging, mouse models, and computational and systems biology. Understanding the basic biological events that precede invasive disease also requires a combination of approaches and disciplines. Taking this research...
Programme Contacts:
Rebecca Fitzgerald
Sarah Bohndiek
Wendy Alderton
Catherine Fitzpatrick
Catherine Atkins
Haematological Malignancies Programme
Haematological Malignancies
The investigation of haematological malignancies (cancers of the blood, bone marrow and lymph nodes) represents a significant area of clinical and research activity. Our understanding of how and why blood cancers develop is underpinned by basic research into how blood cells develop normally and what happens at the earliest stage of malignancy. Research is closely aligned with clinical treatment...
Programme Contacts:
Tony Green
Brian Huntly
Katie Light
Neuro-Oncology Programme
Neuro-Oncology
The CRUKCC Neuro-Oncology Programme is a network of researchers and clinicians in Cambridge working to improve outcomes for brain tumour patients. Over 11,000 people are diagnosed with new cases of brain or central nervous system (CNS) cancer every year in the UK, and the outlook for patients has changed little over the past 10 years. Brain tumours have been defined as a cancer of unmet need by...
Programme Contacts:
Stephen Price
Richard Mair
Gill Kortum
Onco-Innovation Programme
Onco-Innovation
The translation of new discoveries in the laboratory into better treatments for patients is a priority for the CRUK Cambridge Centre. The Onco-Innovation programme, delivered by the Milner Therapeutics Institute, sits at the interface between academia and industry, focused on the conversion of multidisciplinary academic science to commercial and therapeutic applications. Programme members include...
Programme Contacts:
Tony Kouzarides
Susan Galbraith
Rebecca Harris
Ovarian Cancer Programme
Ovarian Cancer
Advanced ovarian cancer is difficult to cure. Most patients are free of the disease after completing initial surgery and chemotherapy but the cancer usually comes back. This is because resistance to chemotherapy develops. Scientists are studying the genetic changes that occur in tumours to understand what causes cancer cells to become resistant to drugs. They are also using new imaging technology...
Programme Contacts:
James Brenton
Paul Pharoah
Marie-Lyne Alcaraz
Paediatric Cancer Programme
Paediatric Cancer
The most common childhood cancers are cancers of the blood (leukaemias and lymphomas), brain, and central nervous system, accounting for over two thirds of the cancers diagnosed in children. Between 2014–2016, around 1,800 children were diagnosed with cancer each year in the UK. More than 8 in 10 children now survive five years or more, compared to 3 in 10 in the 1960s. Consequently, much...
Programme Contacts:
James Nicholson
Suzanne Turner
Gill Kortum
Pancreatic Cancer Programme
Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer deaths. Less than 20% of patients are candidates for surgery at diagnosis. There are few available treatment options for the remaining patients, and so most survive for only a few months. These needs are driving our research and clinical focus at Cambridge. Scientists are involved in research into the biology of pancreatic cancer,...
Programme Contacts:
Giulia Biffi
Bristi Basu
Kate Donoghue
Thoracic Cancer Programme
Thoracic Cancer
Lung and oesophageal cancers share poor five-year survival and have only realised limited improvement in the past decade. Improving the quality and quantity of research into these cancers of unmet need is therefore a key priority for CRUK and one shared by our Thoracic Cancer programme here at the CRUK Cambridge Centre. To improve survival rates, patients need to be identified when their disease...
Programme Contacts:
Robert Rintoul
Daniel Munoz-Espin
Gill Kortum
Urological Malignancies Programme
Urological Malignancies
Prostate and renal cancers are key contributors of cancer related death and morbidity. Early detection and optimal primary treatment improves cure rates and reduces progression to metastasis in both cancer types. Our Clinicians and scientists have developed closely integrated multi-disciplinary research themes including; exploring new markers and imaging for early detection, better modelling of...
Programme Contacts:
Grant Stewart
Sarah Welsh
Sarah Burge