Programme Members

Principal investigators and consultants

  • All members
  • Group leaders
  • Clinical consultants
Wellcome Trust Sanger Institute
Mouse Genomes Project
David performs forward genetic screens to uncover cancer genes and pathways and leads a programme to decode the genomes of several mouse...
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University of Cambridge
Department of Genetics
Wellcome Trust CRUK Gurdon Institute
We investigate the functions chromatin regulatory complexes implicated in human disease using the C. elegans model system. These include...
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Nuclear RNAi pathway and regulation of transposable elements
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Ubiquitin-mediated signaling in cell division
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Regulation of Mammary gland development
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RNA methyltransferases
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Role of centrosome through development and cancer.
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Evolution and function of non-protein-coding RNAs, with focus on their roles in chromatin and transcription control in pluripotency and...
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University of Cambridge
Department of Biochemistry, Department of Pharmacology
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N
Babraham Institute
Role of MAPK in cancer cell survival signalling
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University of Cambridge
Department of Pathology
Wellcome Trust CRUK Gurdon Institute
I have spent the last three decades generally messing around with chromatin with a special focus on histones and their modifications. My...
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Functional Genomics of Breast Cancer. Development and utilisation of Patient derived tumour models in therapeutic research.
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N
Wellcome Trust Sanger Institute
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University of Cambridge
Department of Chemistry
Unilever Centre for Molecular Science Informatics
Previously affiliated with the Lead Discovery Informatics (LDI) group of Novartis in Cambridge/MA, I am now developing and applying...
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Y
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Department of Physiology, Development and Neuroscience
Breast cancer mortality is directly correlated with metastatic disease, and we study mechanisms of breast cancer dissemination: migrating...
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N
University of Cambridge
Department of Physiology, Development and Neuroscience
In many cancers unchecked proliferation is driven by inappropriate activity of signalling pathways, such as the Notch pathway. Activation...
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Y
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University of Cambridge
Cancer Research UK Cambridge Institute
I work on the development of new technologies for the spatial and temporal control of biological events in vivo. Specifically, I am using...
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Chromosome breakage and cancer predisposition
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University of Cambridge
Department of Clinical Biochemistry
Cambridge Institute for Medical Research
Our work aims to determine of the cellular role(s) of myosin motor proteins in intracellular transport processes, cell signaling and...
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AstraZeneca
Primary research interests include ChIP-seq and integrative ChIP-seq/expression analysis.
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University of Cambridge
Department of Physics
My research lies at the connection between biotechnology and cellular biophysics. I have developed techniques in quantitative microscopy,...
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Biology of Ras-induced senescence
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PhD Student in Cancer Genomics
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We aim to understand the molecular basis of chromosome stability in human cells. Genetic predisposition to cancer is commonly precipitated...
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University of Cambridge
Cancer Research UK Cambridge Institute
CRUK Cambridge Institute
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University of Cambridge
Department of Pathology
Defects in cell division often cause abnormal distribution of the genetic material between the two daughter cells. These abnormalities...
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University of Cambridge
Department of Medicine
While stromal cells are well known to control local tissue structure and form an important support network, their roles in maintaining...
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Oocyte and embryo deavelopment, germ cell specification
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University of Cambridge
Wellcome Trust CRUK Gurdon Institute
DNA repair and DNA damage signalling The main focus of research in our lab is to better understand how cells detect DNA damage and signal...
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Babraham Institute
Signalling
I study entosis, a recently described process of live epithelial cell engulfment which occurs in human tumours. My work aims to identify...
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University of Cambridge
Department of Biochemistry
Cancers are lethal diseases in desperate need of new therapeutic approaches: despite dramatic advances in the use of conventional chemo and...
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N
AstraZeneca
Cancer Research UK Cambridge Institute
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University of Cambridge
Department of Genetics
I am interested in chromosome biology and the relationship between the structural organisation of vertebrate chromosomes and their function...
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University of Cambridge
Department of Clinical Biochemistry
Cambridge Institute for Medical Research
The reversible phosphorylation of tyrosine residues on proteins serves as a critical switch in the regulation of fundamental cellular...
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University of Cambridge
Department of Chemistry
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MRC Laboratory of Molecular Biology
Protein and Nucleic Acid Chemistry (PNAC)
Structural and functional analysis of Wnt pathway components
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University of Cambridge
Department of Biochemistry
Our group has been pioneering the use of program analysis techniques for the construction and analysis of executable models describing cell...
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University of Cambridge
Department of Physiology, Development and Neuroscience
Wellcome Trust MRC Cambridge Stem Cell Institute
Stem cells are established during development and remain present in adulthood allowing the body to replace, restore and regenerate dead,...
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Y
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University of Cambridge
Department of Biochemistry
Wellcome Trust CRUK Gurdon Institute
We are interested in understanding the mechanisms underlying remodelling of the actin cytoskeleton. Force generation by actin...
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University of Cambridge
Cancer Research UK Cambridge Institute
The goal of our laboratory is to understand the molecular networks that control cell division during development and adult tissue...
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University of Cambridge
Department of Genetics
Our laboratory studies the regulation of progression through mitosis and meiosis in animal cells. The high degree of evolutionary...
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University of Cambridge
Department of Oncology, Department of Biochemistry
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University of Cambridge
Department of Astronomy
My group focuses on nonequilibrium phenomena in the natural world, with particular emphasis on biological physics. We strive for a holistic...
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Wellcome Trust Sanger Institute
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University of Cambridge
Department of Biochemistry
Science Communication Specialist, Cell and Molecular Biology Programme
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University of Cambridge
Department of Biochemistry
Cambridge Systems Biology Institute
The Griffin group specialises in the use of NMR spectroscopy and mass spectrometry approaches to high throughput metabolomics. In the area...
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Wellcome Trust CRUK Gurdon Institute
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Babraham Institute
I have a long term interest in the PI3K signalling system and how it operates as a key signal integrator in a range of signallling networks...
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I am currently in charge of the liquid chromatography-mass spectrometry-based metabolomics facility in Christian Frezza?s laboratory. Here...
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I am interested in how inflammation contributes to the onset and progression of pregnancy-associated breast cancer. I use mouse models to...
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Department of Veterinary Medicine
I study the mammary gland and tumours developing in this tissue. My particular field of interest encompasses the interactions between...
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We are using fragment based drug discovery methods to target a traditionally difficult class of drug targets, with emphasis on inhibition...
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University of Cambridge
Cancer Research UK Cambridge Institute
Cancer development and epigenetic change, especially related to imprinting.
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N
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N
University of Cambridge
Department of Pharmacology
Our research focuses on a class of proteins known as tandem-repeat proteins such as ankyrin, tetratricopeptide and leucine-rich repeats....
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Y
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University of Cambridge
Department of Biochemistry
Proteomic approaches to plasma-membrane assemblies: Membrane proteins cluster together selectively as spatially-restricted, functionally...
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University of Cambridge, MISSION Therapeutics Ltd, Wellcome Trust Sanger Institute
Department of Biochemistry
Wellcome Trust CRUK Gurdon Institute
The main focus of research in our lab is to better understand how cells detect DNA damage and signal its presence to the DNA repair,...
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We work on how the body responds to hypoxia, or low levels of tissue oxygen.  This is relevant to a number of diseases, including cancer,...
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University of Cambridge
Department of Physics
Imaging and sensing instrumentation research for oncology applications
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MRC Laboratory of Molecular Biology
Conserved mechanisms in chemotaxis. How cells sense and move in chemical gradients; how they make projections - pseudopodia and blebs -...
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Biology of MHC class I and class II antigen processing and presentation pathways.
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University of Cambridge
Department of Biochemistry
We are interested in understanding of the links between deficiencies in the DNA damage response and the molecular nature of disease....
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Mechanisms and models of cancer.
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University of Cambridge
Department of Zoology
For a cell to proliferate in cancer, and during normal development or tissue maintenance, it must replicate its chromosomal DNA. We are...
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University of Cambridge
Department of Biochemistry
University of Cambridge
The study of the structure and function of protein complexes, mainly using either NMR spectroscopy or X-ray crystallography, but also...
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University of Cambridge
Department of Medicine
Cambridge Institute for Medical Research
We study MHC I molecules and other critical cell surface receptors. We showed that the cancer-causing herpesviruses (KSHV) pirated...
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My lab studies cell division in human cells, with particular focus on regulation by ubiquitin-mediated proteolysis. We use time-lapse...
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University of Cambridge
Department of Biochemistry
The use of classical, germ-line genetics to define gene function in vertebrates is severely limited by embryonic lethality, developmental...
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Babraham Institute
Laboratory of Molecular Signalling
The role and molecular regulation of protein kinases in cancer.
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University of Cambridge
Department of Biochemistry
I study the processes involved in DNA replication in eukaryotes, including the mechanism of priming by the replicative primase and the...
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University of Cambridge
Department of Physics
Working on instrument development for optical imaging methods for the diagnosis and treatment of gastrointestinal cancers.
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University of Cambridge
Department of Zoology
Wellcome Trust CRUK Gurdon Institute
I am interested in the role played by two S/T protein kinases in mitosis (Aurora A and Cdk1). Both of them have several key roles at...
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University of Cambridge
Department of Biochemistry
Wellcome Trust CRUK Gurdon Institute
Our main goal is to understand how cells interpret genetic and epigenetic information as well as environmental cues to determine their...
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Metabolic response of the cells adapts to proliferation requirements indicating that there is a cross talk between cell cycle and metabolic...
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University of Cambridge
Department of Physics
We are a small, highly interactive and international research team whose passion is using new technological innovations to improve our...
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AstraZeneca
Early Drug Development Phase 1 studies First in human studies Cancer
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University of Cambridge
Department of Biochemistry
Small G proteins are molecular switches in cellular signal transduction. Many small G proteins that we are studying, such as Ras and Ral,...
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University of Cambridge
Department of Biochemistry
Wellcome Trust CRUK Gurdon Institute
Genome-scale CRISPR/Cas9-based screens for new factors of the DNA damage response and DNA repair in cancer and human genetic diseases
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University of Cambridge
Department of Veterinary Medicine
Elizabeth Murchison studies the genetics and evolution of clonally transmissible cancers. Transmissible cancers are unusual cancers that...
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European Bioinformatics Institute, Wellcome Trust Sanger Institute
Open Targets Postdoctoral Fellow responsible for the development of new algorithms and computational tools for scoring cancer in vitro...
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University of Cambridge
Cancer Research UK Cambridge Institute
CRUK Cambridge Institute
cellular senescence
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University of Cambridge
Cancer Research UK Cambridge Institute
To understand mechanisms of cellular response to the stresses, such as cellular senescence and apoptosis.
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University of Cambridge
Department of Medicine
Cambridge Institute for Medical Research
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Y
MRC Laboratory of Molecular Biology
Department of Biochemistry
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University of Cambridge
Cancer Research UK Cambridge Institute
Our goal is to understand the systems-level transcriptional mechanisms underlying mammalian cell specification, which are often perturbed...
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University of Cambridge
Department of Biochemistry
Our work focuses on the relationship between structure and function in small G proteins and their effectors and regulators. These proteins...
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MRC Laboratory of Molecular Biology
Structural Studies
We use a hybrid approach to study the structure and function of multi-protein complexes. We focus on complexes involved in the regulation...
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MRC Laboratory of Molecular Biology
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MRC Cancer Unit
Hutchison MRC Research Centre
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University of Cambridge
Department of Surgery
Cambridge Institute for Medical Research
Our principal objective is to define the molecular and genetic basis for the maintenance of the pluripotent status of human embryonic stem...
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University of Cambridge
Department of Biochemistry
Luca's research focuses on the relationship between cancers and physiological but not homeostatic processes like tissue regeneration and...
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University of Cambridge
Department of Biochemistry
The faithful inheritance of genetic information is essential to cellular life. Successful transmission of the genetic material requires the...
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My main interest is understanding what is behind the heterogeneity of breast cancer. Through the identification of cell fate regulators in...
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My research tackles basic aspects of cell cycle control (particularly during mitosis) and genome stability in the context of tumour...
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MISSION Therapeutics Ltd
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Department of Haematology
Cambridge Institute for Medical Research
Transcription factor networks relating to the pathogenesis of acute myeloid leukaemia. This involves cloning a specific mutation into an...
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University of Cambridge
Cancer Research UK Cambridge Institute
My research has previously focused on mechanisms involved in tamoxifen resistant breast cancer.  Recently I have moved groups and my...
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Understanding how cancer cells acquire and maintain metastatic traits. The state-of-the-art multi-disciplinary approach combines functional...
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Department of Medical Genetics
Cambridge Institute for Medical Research
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School of Clinical Medicine
CRUK Cambridge Institute
Alasdair heads up a specialised team that provide a centralised ‘Hub’ for the innovation and application of state-of-the-art Genome Editing...
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MRC Laboratory of Molecular Biology
My lab is interested in the mechanisms that alleviate arrested DNA replication and the impact their loss has on mutagenesis and on the...
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University of Cambridge
MRC Cancer Unit
Hutchison MRC Research Centre
My research focuses on the role of metabolic reprogramming during transformation and tumour evolution. We are interested in kidney cancer...
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University of Cambridge
Department of Genetics
Spindle morphogenesis is regulated by cyclin-dependent kinases (CDKs) and monitored by checkpoints to enforce accurate chromosomal...
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Our aim is to understand the function and regulation of receptor tyrosine phosphatases in vivo using proteomics, cell biology and mouse...
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DNA damage repair
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University of Cambridge
Department of Genetics
Wellcome Trust CRUK Gurdon Institute
Most tumours arise from epithelial tissues composed of polarised cells that stick together to form sheets, and a loss of polarity is a...
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MRC Laboratory of Molecular Biology
Nuclear trafficking and structural cell biology
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Long non-coding RNAs (lncRNAs) play key roles in various biological processes and their deregulation has been linked to different diseases...
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University of Cambridge
Department of Pathology
Cambridge Institute for Medical Research
Immunogenetics and functions of the MHC Immunogenetics of NK receptors and related molecules
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University of Cambridge
Department of Clinical Neuroscience, Department of Engineering
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University of Cambridge
Department of Pharmacology
Our research focusses on molecular mechanisms of multidrug transport proteins that efflux cytotoxic drugs away from their intracellular...
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MRC Laboratory of Molecular Biology
Medical Research Council Laboratory of Molecular Biology
We work on the aggregation mechanism of the tumor suppressor protein, p53, and developing novel anti-cancer drugs that function by...
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MRC Laboratory of Molecular Biology
Laboratory of Molecular Biology
Many signal transduction pathways cells involve enzymes that generate either soluble or membrane-resident second messengers by modifying...
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Department of Clinical Biochemistry
CRUK Cambridge Institute, Cambridge Institute for Medical Research
My project focuses on understanding the role of the putative tumour suppressor PTPRK in colorectal cancer. PTPRK is a cell surface protein...
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University of Cambridge
Wellcome Trust CRUK Gurdon Institute
The Regulation of Replication Initiation in Eukaryotes Faithful inheritance of the genome from mother to daughter cell requires that it is...
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