Pathania Group

Manav Pathania’s lab works on elucidating the role of chromatin remodelling in neural stem cell biology and paediatric brain tumour development. Epigenomic deregulation is a hallmark feature of many distinct types of brain tumour and has been implicated in tumour heterogeneity and the development of resistance. We will combine developmental neurobiology, epigenetics, stem cell science and genomics approaches to reveal how epigenomes are rewired to serve oncogenic programmes in paediatric high-grade gliomas, by carefully characterising and manipulating the molecularly and histologically accurate in vivo models we have developed.