Miss Antonella Santoro

University of Cambridge

University departments
Department of Haematology
University institutes
Wellcome Trust MRC Cambridge Stem Cell Institute

Position: PhD student
Personal home page:

PubMed journal articles - click here

Miss Antonella Santoro is pleased to consider applications from prospective PhD students.

Research description

The central aim of this PhD project is to characterise alterations in the niche of HSC, imposed by malignant B cells, and to understand their functional implications for HSC differentiation and renewal. In particular, the following questions will be addressed in this project: how do malignant B cells change the cellular composition of HSC-niches? Which signalling pathways are required for these alterations and how do lymphoma-remodelled HSC niches affect HSC self-renewal and differentiation.
This work will elucidate the patho-biology underlying the bone marrow failure in patients with haematological malignancies and likely provide new approaches for therapeutic interventions to counteract the impairment of HSC functions in advanced disease cancer patients.

Research Programme
Haematological Malignancies
Methods and technologies
Cell culture
Clinical trials
Fluorescence microscopy
Gene expression profiling
Imaging
Immunohistochemistry
In vivo modelling
Microscopy
PCR
Statistical analysis
Tumour type interests
Leukemia
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Recent publications:
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