Dr Ben Hall

University of Cambridge

University departments
MRC Cancer Unit
University institutes
Hutchison MRC Research Centre

Position: Royal Society URF
Personal home page: http://www.mrc-cu.cam.ac.uk/research/benjamin-hall-folder
Email:   Public email address:  bh418@mrc-cu.cam.ac.uk

PubMed journal articles - click here

Dr Ben Hall is pleased to consider applications from prospective PhD students.

Research description

Whilst cancer is extremely common on the population level, it is extremely unlikely for an individual cell to become cancerous. This rarity poses a problem for modelling and understanding the progression of the disease. My group uses discrete and hybrid models, more commonly used in software development than in biology, to address this problem.

Research Programme
Early Detection
Methods and technologies
Computational modelling
Tumour type interests
Leukemia
Oesophagus
Pancreas
bh418
Recent publications:
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Key publications

Emergent Stem Cell Homeostasis in the C. elegans Germline Is Revealed by Hybrid Modeling.Hall BA, Piterman N, Hajnal A, Fisher J. Biophys J. 2015 Jul 21;109(2):428-38. doi: 10.1016/j.bpj.2015.06.007. Probing the Solution Structure of IKKy and its Interaction with Kaposi?s Sarcoma Associated Herpes Virus Flice Interacting Protein and IKK Subunit Beta by EPR Spectroscopy. Bagnéris C, Rogala KB, Baratchian M, Zamfir V, Kunze MB, Dagles S, Pirker KF, Collins MK, Hall BA, Barrett TE, Kay CW. J Biol Chem. 2015 May 14. pii: jbc.M114.622928. Drug target optimization in chronic myeloid leukemia using innovative computational platform. Chuang R, Hall BA, Benque D, Cook B, Ishtiaq S, Piterman N, Taylor A, Vardi M, Koschmieder S, Gottgens B, Fisher J. Sci Rep. 2015 Feb 3;5:8190. doi: 10.1038/srep08190. Logic programming to predict cell fate patterns and retrodict genotypes in organogenesis. Hall BA, Jackson E, Hajnal A, Fisher J. J R Soc Interface. 2014 Sep 6;11(98):20140245. doi: 10.1098/rsif.2014.0245. Computing Clinically Relevant Binding Free Energies of HIV-1 Protease Inhibitors.Wright DW, Hall BA, Kenway OA, Jha S, Coveney PV. J Chem Theory Comput. 2014 Mar 11;10(3):1228-1241. Primary and secondary dimer interfaces of the fibroblast growth factor receptor 3 transmembrane domain: characterization via multiscale molecular dynamics simulations. Reddy T, Manrique S, Buyan A, Hall BA, Chetwynd A, Sansom MS.Biochemistry. 2014 Jan 21;53(2):323-32. doi: 10.1021/bi401576k. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Nat Commun. 2013;4:2465. doi: 10.1038/ncomms3465. Finding instability in biological models. Cook B, Fisher J, Hall B, Ishtiaq S, Juniwal G, Piterman N. 26th International Conference on Computer Aided Verification (2014).

IKK-gamma in complex with binding partners