Professor Chris Abell

University of Cambridge
Department of Chemistry

Position: Professor
Personal home page: http://www.ch.cam.ac.uk/staff/ca.html

PubMed journal articles - click here

Professor Chris Abell is pleased to consider applications from prospective PhD students.

Research description

Fragment based drug discovery Mechanistic enzymology research on reactions in microdroplets in microfluidics, with potential applications in chemistry and biology

Research Programme
Onco-Innovation
Keywords
synthetic organic chemistry
biophysics
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Recent publications:
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Key publications

Optimization of inhibitors of Mycobacterium tuberculosis pantothenate synthetase based on group efficiency analysis. A W Hung, H L Silvestre, S Wen, G P C George, J Boland, T L Blundell, A Ciulli, C Abell ChemMedChem 2016, 11, 38-42. Selective targeting of the TPX2 site of importin-α using fragment-based ligand design. R S Holvey, E Valkov, D Neal, M Stewart, C Abell ChemMedChem 2015, 10, 1232-1239. Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy. S Mageed, F Cunningham, A Hung, H Silvestre, S Wen, T Blundell, C Abell, G McConkey Antimicrob. Agents Chemother. 2014, 58, 6345-6353. A three-stage biophysical screening cascade for fragment-based drug discovery. E H Mashalidis, P Śledź, S Lang, C Abell Nature Protocols 2013, 8, 2309-2324. Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121. S A Hudson, K J McLean, S Surade, Y-Q Yang, D Leys, A Ciulli, A W Munro, C Abell. Angew. Chemie Intl. Ed. 2012, 51, 9311-9316.

electron density of a fragment bound to a target protein