Dr Christopher Smith
Position: Senior Research Associate
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I am currently working as senior research associate in Dr. Nitzan Rosenfeld's lab at the CRUK Cambridge Institute. We are studying the use of circulating cell-free DNA (cfDNA) as a potential diagnostic, predictive and prognostic biomarker for various cancers. Various studies (including a series of hallmark studies released by Nitzan Rosenfeld and colleagues) have shown the potential for this material for tracking disease (response to therapy, evolution of clonal populations, etc). I am currently involved in efforts to utilise current technologies with cfDNA - particularly the application of whole exome- and genome-sequencing to patient samples. The hope is that these new technologies might complement the techniques already optimised and used in cfDNA analysis (e.g. Tam-Seq), providing a broad and unbiased view of the genomic landscape of a tumour, overcoming confounding biases of clonal heterogeneity, and allowing longitudinal profiling for treatment response studies.
In particular I am studying the levels and potential clinical utility of ctDNA in renal cancers.
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