Dr Cristina Pina

University of Cambridge

University departments
Department of Haematology

Position: Kay Kendall Leukaemia Fund Intermediate Fellow
Personal home page: http://www.haem.cam.ac.uk/staff/senior-staff/dr-cristina-pina/

PubMed journal articles - click here

Research description

We aim to understand the role of transcriptional noise in normal and malignant cell fate decisions, and to explore candidate noise modulatory pathways as therapeutic targets in haematological malignancy. We have a particular interest in acute myeloid leukaemia, a condition that exemplifies disruption of the normal haematopoietic tree through imbalance between self-renewal and differentiation. We use molecular and functional analysis of normal and leukaemic haematopoiesis in both human and mouse models to inform our research, and have a particular focus in single-cell transcriptional studies.

Research Programme
Haematological Malignancies
Methods and technologies
Cell culture
Gene expression profiling
In vivo modelling
PCR
Proteomics
RNAi
Tumour type interests
Leukemia
Keywords

Leukaemogenesis; Acute Myeloid Leukaemia; Transcriptional noise; Stem cells; Haematopoiesis; Single-cell analysis

cp533
Recent publications:
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Key publications

1.Pina C, Teles J, Fugazza C, May G, Guo Y, Ohlsson M, Eden P, Peterson C, Enver T, Ddit3 is a nodal regulator of erythro-myeloid lineage specification. Cell Reports 2015 doi: 10.1016/j.celrep.2015.05.016 (3 co-first authors) 2.Teles J, Enver T, Pina C*, Single-cell PCR profiling of gene expression in hematopoiesis. Methods Mol Biol 2014; 1185: 21-42 doi: 10.1007/978-1-4939-1133-2_3. (*corresponding author) 3.Teles J, Pina C, Eden P, Ohlsson M, Enver T, Petersen C, Transcriptional regulation of lineage commitment ? a stochastic model of cell fate decisions. PLoS Comput Biol 2013 9(8):e1003197. doi: 10.1371/journal.pcbi.1003197. 4.Karlsson G, Rorby E, Pina C, Soneji S, Miharada K, Fugazza C, Reckzeh K, Karlsson C, Gupta R, Martens J, Stunnenberg HG, Karlsson S, Enver T, The tetraspanin CD9 affords high-purity capture of all long-term reconstituting hematopoietic cells. Cell Reports 2013 doi:pii: S2211-1247(13)00382-3. 10.1016/j.celrep.2013.07.020 5.Pina C, Fugazza C, Tipping AJ, Brown J, Soneji S, Teles J, Petersen C, Enver T, Inferring rules of lineage commitment in haematopoiesis. Nat Cell Biol 2012; 14: 287-294. (3 first authors equal contribution) doi:10.1038/ncb2442