Professor Douglas Fearon
Professor Douglas Fearon is pleased to consider applications from prospective PhD students.
We study the role of the FAP+ cell, which is a specific type of stromal cell that is found in all human adenocarcinomas. We have shown in a mouse model that conditional depletion of the FAP+ stromal cell from the tumoral microenvironment leads to immune control of tumor growth. We have also found, somewhat to our surprise, that the FAP+ cell comprises a stromal cell lineage that resides in many normal tissues, and that cancer may deplete these tissues of this cells, by an unknown mechanism, and cause certain systemic effects of cancer, such as cachexia and anemia.
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Heffner M, Fearon DT. Loss of T cell receptor-induced Bmi-1 in the KLRG1+ senescent CD8+ T lymphocyte. Proc Natl Acad Sci USA. 2007; 104:13414-13419. Bannard O, Kraman M, Fearon DT. Secondary replicative function of CD8+ T cells that had developed an effector phenotype. Science. 2009; 323:505-09. Kraman M, Bambrough PJ, Arnold JA, Roberts EW, Magiera L, Jones JO, Gopinathan A, Tuveson DA, Fearon, DT. Suppression of anti-tumor immunity by stromal cells expressing Fibroblast Activation Protein-?. Science. 2010; 330:827-830. Bannard O, Kraman M, Fearon DT. Cutting edge: Virus-specific CD8+ T cell clones and the maintenance of replicative function during a persistent viral infection. J Immunol. 2010;185:7141-7145. Yeo CJ, Fearon DT. T-bet-mediated differentiation of the activated CD8+ T cell. Eur J Immunol. 2011;41:60-66.