Dr David Kent

University of Cambridge

University departments
Department of Haematology
University institutes
Wellcome Trust MRC Cambridge Stem Cell Institute

Position: Group Leader
Personal home page: https://www.york.ac.uk/biology/research/infection-immunity/david-kent/

PubMed journal articles - click here

Research description

My research focuses on normal and malignant blood stem cell biology.  Specifically, I am interested in understanding stem cell heterogeneity and fate choice through single stem cell biology including quantitative and biophysical approaches.

Research Programme
Haematological Malignancies
Methods and technologies
Cell culture
Computational modelling
DNA sequencing
Fluorescence microscopy
Gene expression profiling
In vivo modelling
Model organisms
Statistical analysis
Tumour type interests
Flow Cytometry
 single cell culture
 single cell PCR
myeloproliferative neoplasms
Recent publications:
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Key publications

1) Schulte R, Wilson NK, Prick JC, Cossetti C, Maj MK, Gottgens B, Kent DG. Index sorting resolves heterogeneous murine hematopoietic stem cell populations. Exp Hematol. 2015 Sep;43(9):803-11. PMCID: PMC4571925

2) *Wilson NK, *Kent DG, *Buettner F, Shehata M, Macaulay IC, Calero-Nieto FJ, Sánchez Castillo M, Oedekoven CA, Diamanti E, Schulte R, Ponting CP, Voet T, Caldas C, Stingl J, Green AR, Theis FJ, Göttgens B. *co-first authors. Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations. Cell Stem Cell. 2015 Jun 4;16(6):712-24. PMCID:PMC4460190

3)*Ortmann CA, *Kent DG, Nangalia J, Silber Y, Wedge DC, Grinfeld J, Baxter EJ, Massie CE, Papaemmanuil E, Menon S, Godfrey AL, Dimitropoulou D, Guglielmelli P, Bellosillo B, Besses C, Döhner K, Harrison CN, Vassiliou GS, Vannucchi A, Campbell PJ Green AR. *co-first authors. Effect of mutation order on myeloproliferative neoplasms. N Engl J Med. 2015 Feb 12;372(7):601-12. PMCID:PMC4660033

4) Kent DG, Li J, Tanna H, Fink J, Kirschner K, Pask DC, Silber Y, Hamilton TL, Sneade R, Simons BD, Green AR. Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. PLoS Biol. 2013;11(6):e1001576. PMCID:PMC3672217

5) Kent DG, Copley MR, Benz C, Wöhrer S, Dykstra BJ, Ma E, Cheyne J, Zhao Y, Bowie MB, Zhao Y, Gasparetto M, Delaney A, Smith C, Marra M, Eaves CJ. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood. 2009 Jun 18;113(25):6342-50. PMID:19377048