Miss Elisabetta Zambon
Position: PhD student
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The current PhD project focus on the identification and characterization of the key transcription regulators which drive the TNBC phenotype. We will aim to mark putative regulatory regions of the top ten most differentially regulated genes in TNBC compared to other subtypes of breast cancer. To achieve this we are using a combination of a novel proteomics approach with the CRISPR/Cas9 technology. By using a catalytically dead version of the Cas9 protein (dCas9) we would mark the putative regulatory regions of the genes of interest in the cell. We would then perform RIME proteomics to identify which proteins are potentially bound at these regions and are preferably common between all/some of the loci studied.
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