Dr Frank McCaughan

University of Cambridge

University departments
Department of Biochemistry
NHS or other affiliations
Cambridge University Hospitals NHS Trust

Position: Wellcome Trust Intermediate Clinical Fellow / Honorary Consultant
Personal home page:

PubMed journal articles - click here

Dr Frank McCaughan is pleased to consider applications from prospective PhD students.

Research description

My research is focused on understanding the early driver events that are critical to the development of squamous lung cancer (SQC) and translating this knowledge into novel approaches to early detection and novel therapeutics or chemoprevention agents. We have evidence that amplification and deregulation of SOX2 is a key event in the pathogenesis of SQC. We have developed novel preclinical model systems to deconstruct the functional impact of SOX2 activation in the pathogenesis of this disease and to define therapeutic vulnerabilities.

Research Programme or Virtual Institute
Thoracic Cancer
Methods and technologies
Cell culture
DNA sequencing
Gene expression profiling
In vivo modelling
Model organisms
Tumour type interests
Recent publications:
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Key publications

F Gao, E Pfeifer, H Farah, E Karampini, D Dua, N Kamal, P Cane, K Tobal, T Sethi, *J Spicer, and *F McCaughan. Microdroplet digital PCR - detection and quantitation of biomarkers in archived tissue and serial plasma samples in patients with lung cancer. Journal of Thoracic Oncology 2015;10(1):212-7 Pipinikas CP, Kiropoulos TS, Teixeira VH, Brown JM, Varanou A, Falzon M, Capitanio A, Bottoms SE, Carroll B, Navani N, McCaughan F, George PJ, Giangreco A, Wright NA, McDonald SAC, Graham TA, Janes SM. Cell migration leads to spatially distinct but clonally related airway cancer precursors. Thorax 2014; 69:548?557. Day E, Poulogiannis G, McCaughan F, Mulholland S, Arends MJ, Ibrahim, AEK, Dear, PH. IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer. IJEP 2013 94:203-211 McCaughan F, Pipinikas CP, Janes SM, Rabbitts PH, Dear PH. Genomic evidence of clonal expansion, dispersal and progression in bronchial dysplasia. Journal of Pathology 2011 224:153-9 *Pole JC, *McCaughan F, Howarth KD, Dear PH, Edwards PAW. Single-molecule analysis of genome rearrangements in cancer. Nucleic Acid Research 2011 doi 10.1093/nar/gkr227 * Joint first authors McCaughan F, Pole JC, Bankier AT, Konfortov BA, Carroll B, Falzon M, Rabbitts TH, George PJ, Dear PH, Rabbitts PH. Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer. Am J Respir Crit Care Med. 2010 1;182(1):83-91.5