Mr George Tetley

University of Cambridge

University departments
Department of Biochemistry

Position: PhD student
Personal home page:

PubMed journal articles - click here

Research description

My research as part of the Owen-Mott lab is in designing a small peptide therapeutic for Ras driven cancers. Abberant Ras signalling in cells can be disrupted by inhibition of downstream effectors, one of which is Cdc42. We are basing this peptide on a specific Cdc42 effector protein - ACK - and aiming to improve binding and delivery in order to inhibit effector signalling. I am working in collaboration with Isogenica, whose CIS display technology allows rapid peptide affinity maturation. Lead candidates will be taken forward to in vitro assays.

Research Programme
Methods and technologies
DNA sequencing
Protein biochemistry
Protein purification
Recombinant protein expression
Recent publications:
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