Dr Karol Nowicki-Osuch

University of Cambridge

University departments
MRC Cancer Unit
University institutes
CRUK Cambridge Institute

Position: Research Associate
Personal home page:

PubMed journal articles - click here

Research description

Oesophageal Adenocarcinoma is on the rise across the developed countries and over the recent years, significant progress has been made in improving our understanding of the clinical features of the disease including its genetic and epigenetic heterogeneity, and associated survival outcomes. However, our understanding of the early phases of Oesophageal Adenocarcinoma development is poorly understood. The general consensus is that Oesophageal Adenocarcinoma develops in the distal oesophageal via its precursor – Barrett’s Oesophagus. However, the question of Barrett’s Oesophagus origin and the molecular programme of its development have been widely debated in the literature. In my current research, I tackle these questions using single-cell RNA-seq, epigenetic profiling and mitochondrial lineage tracing. I also use basic biology methods to test the hypothesis derived from these methods.

About me:

I completed my PhD in Molecular and Cellular Biology at the University of Manchester in 2015 and moved to Cambridge soon after to start my postdoctoral training at the MRC Cancer Unit. Currently, I am working in the group of Professor Rebecca Fitzgerald and I apply my basic and computational biology experience to investigate the natural history of Oesophageal Adenocarcinoma and its pre-cancerous condition called Barrett’s oesophagus. Additionally, I am a fellow of the Canada-UK Postdoctoral Fellowship in Entrepreneurship and Innovation, a programme that combines excellent training and skills’ development with an opportunity to tackle the UN global challenges.

In my spare time, I am passionate about bringing science to the broader community and in improving patients’ and scientists’ wellbeing. Outreach activities are also a great way to involve young people and enthuse them to consider a career in science.
External links:
Canada UK Entrepreneurial and Innovation Fellowship
https://www.canadaukfoundation.org/canadian-entrepreneurial-and-innovati...
MRC Cancer Unit
https://www.mrc-cu.cam.ac.uk/research/rebecca-fitzgerald/fitzgerald-group

Research Programme
Early Detection
Methods and technologies
Bioinformatics
Cell culture
Computational modelling
DNA sequencing
Gene expression profiling
Genomics
Immunohistochemistry
In situ hybridization
Microscopy
PCR
Tumour type interests
Oesophagus
Stomach
kpn25
Recent publications:
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Key publications

Lung, spleen and oesophagus tissue remains stable for scRNAseq in cold preservation
E. Madissoon, A. Wilbrey-Clark, R.J. Miragaia, K. Saeb-Parsy, K. Mahbubani, N. Georgakopoulos, P. Harding, K. Polanski, K. Nowicki-Osuch, R.C. Fitzgerald, K.W. Loudon, J.R. Ferdinand, M.R Clatworthy, A. Tsingene, S. Van Dongen, M. Dabrowska, M. Patel, M.J.T. Stubbington, S. Teichmann, O. Stegle, K.B. Meyer
bioRxiv 741405; doi: https://doi.org/10.1101/741405

How Deep Are the Roots of Barrett's Esophagus?
Nowicki-Osuch K, Di Pietro M.
Gastroenterology. 2019 May;156(6):1928-1930. doi: https://doi.org/10.1053/j.gastro.2019.03.036.
PMID: 30926347

EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas.
Nowicki-Osuch K, Li Y, Challinor M, Gerrard DT, Hanley NA, Sharrocks AD.
PLoS One. 2017 Jul 21;12(7):e0181902. doi: https://doi.org/10.1371/journal.pone.0181902.
PMID: 28732076