Dr Pierre Lao-Sirieix


Position: Other
Personal home page:

PubMed journal articles - click here

Research description

As part of the Personalised Healthcare and Biomarker department of AstraZeneca, my role is to align the development of companion diagnostics assays with drug development; from investigational to regulated assays.

Research Programme
Early Cancer Institute
Methods and technologies
Clinical trials
DNA sequencing
Gene expression profiling
Recent publications:
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Key publications

Ross-Innes CS, Becq J, Warren A, Cheetham RK, Northen H, O’Donovan M, Malhotra S, Ivakhno S, He M, Weaver JMJ, Lynch AG, Kingsbury Z, Ross M, Humphray S, Bentley D, Fitzgerald RC on behalf of the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Study Group, Whole genome sequencing provides novel insight into the clonal architecture of Barrett’s esophagus and esophageal adenocarcinoma, Nature Genetics, 2015, 47(9)

Ross-Innes CS, Debiram-Beecham I, O’Donovan M, Walker E, Varghese S, Lao-Sirieix P, Lovat L, Griffin M, Ragunath K, Haidry R, Sami SS, Kaye P, Novelli M, Disep M, Ostler R, Aigret B, North BV, Bhandari P, Haycock A, Morris A, Attwood S, Dhar A, Rees C, Rutter MDD, Sasieni PD and Fitzgerald RC on behalf of the BEST2 study group, Evaluation of a minimally-invasive cell sampling device coupled with assessment of trefoil factor 3 expression for diagnosing Barrett's Esophagus: a multi-center case-control study, PLoS Med, DOI: 10.1371/journal.pmed.1001780

Katzka DA, Geno DM, Ravi A, Smyrk TC, Kita H, Lao-Sirieix P, Miramedi A, Debiram I, O’Donovan M, Kita H, Kephart GM, Kryzer LA, Alexander JA, Fitzgerald RC, Cytosponge Evaluation of Eosinophilic Esophagitis in Comparison to Endoscopy: Accuracy, Safety and Tolerability, Clinical Gastroenterology and Hepatology, 2014, In Press

Weaver JMJ, Ross-Innes CS, Shannon N, Lynch AG, Forshew T, Barbera M, Murtaza M, Ong CAJ, Lao-Sirieix P, Dunning MJ, Smith L, Smith ML, Anderson CL, Carvalho B, O’Donovan M, Underwood TJ, A May, Grehan N, Hardwick R, Davies J, Oloumi A, Aparicio S, Caldas C, Eldridge MD, Edwards PAW, Rosenfeld N, Tavaré S, Fitzgerald RC, and the OCCAMS consortium, Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis, Nature Genetics, 2014: doi:10.1038/ng.3013