Dr Matthew Hoare

University of Cambridge

University departments
Department of Medicine
University institutes
CRUK Cambridge Institute
NHS or other affiliations
Cambridge Hospitals NHS Foundation Trust

Position: Clinician Scientist and Honorary Consultant
Personal home page:

PubMed journal articles - click here

Research description

Cellular senescence and oncogene induced senescence in particular is a potent tumour suppressor mechanism. Hepatocytes from subjects with chronic liver disease demonstrate evidence of senescence which may underpin declining liver function and place subjects at risk of HCC. We have utilised plasma membrane proteomics to develop a cell surface phenotype of senescence in order to identify signalling pathways that develop, reinforce and transmit the senescent phenotype to surrounding cells. We are developing tools to identify cellular senescence in vivo and are developing in vivo imaging modalities to image senescence in live subjects.

Research Programme
Aerodigestive Cancer
Secondary Programme
Early Detection
Methods and technologies
Cell culture
Clinical practice
Gene expression profiling
Immunohistochemistry
In vivo modelling
Model organisms
PCR
Proteomics
Tumour type interests
Liver
Keywords
Hepatocellular carcinoma
cirrhosis
mwh20
Recent publications:
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