Dr Philip Zegerman
Dr Philip Zegerman is pleased to consider applications from prospective PhD students.
The Regulation of Replication Initiation in Eukaryotes Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. Failure to perfectly replicate the genome is a likely source of cell death and the mutations that are the root cause of cancer. As a result, replication is strictly regulated both within the cell cycle and in the face of DNA lesions and it is these levels of regulation that form the focus of our research interests.
Budding yeast genetics
Symplectic Elements feed provided by Research Information, University of Cambridge
Zegerman P and Diffley JF. Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation Nature. 2010 467 474-8 Zegerman P and Diffley JF. DNA replication as a target of the DNA damage checkpoint. DNA repair. 2009 8:1077-88. Zegerman P and Diffley JF. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature. 2007 445:281-5