Mr Simon Buczacki

Cambridge University Hospitals NHS Foundation Trust

University departments
Department of Haematology
University institutes
Wellcome Trust MRC Cambridge Stem Cell Institute

Position: Group Leader, CRUK Advanced Clinician Scientist & Honorary Consultant Colorectal Surgeon
Personal home page:

PubMed journal articles - click here

Mr Simon Buczacki is pleased to consider applications from prospective PhD students.

Research description

Simon Buczacki is an academic surgical oncologist working with Cancer Research UK, the University of Cambridge and the Cambridge Colorectal Unit at Addenbrooke’s Hospital, UK.

Simon went to medical school at the University of Cambridge and then undertook his junior doctor training in and around Addenbrooke's Hospital, Cambridge. He carried out a PhD at the Cancer Research UK, Cambridge Institute in the laboratory of Doug Winton. Following on from his doctoral studies he obtained a highly competitive post-doctoral Cancer Research UK Clinician Scientist Fellowship. He was then appointed as Honorary Consultant Colorectal Surgeon at Addenbrooke's Hospital in 2015. In 2018 he was recruited to the world-famous Cambridge Stem Cell Institute as a Group Leader where he currently runs a basic science laboratory funded by a prestigious Cancer Research UK Advanced Clinician Scientist Fellowship and additional funding from the Medical Research Council and the Wellcome Trust. He has published widely including major papers in Nature, Science and Cell Stem Cell. His current research interests focus on the biology and targetting of cancer stem cell populations and investigating the relationship between intratumoral genetic heterogeneity and cell identity.

Simon has been an active medical teacher for over two decades, currently as a Fellow and Director of Studies for Medicine at Clare College, Cambridge. He co-leads the Aerodigestive Programme and sits on the executive committee for the Cambridge Cancer Centre. His clinical practice is focused on the surgical managment of colorectal cancer and he has a sub-specialty practice in advanced abdominal surgery for small bowel neuroendocrine tumours.

Research Programme
Aerodigestive Cancer
Methods and technologies
Cell culture
Confocal microscopy
Gene expression profiling
In vivo modelling
Model organisms
Tumour type interests
Recent publications:
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Key publications

Nature. 2013. Mar 7;495(7439):65-9. Article. Intestinal label-retaining cells are secretory precursors expressing Lgr5.  Buczacki SJA, Ireland Zecchini H, Nicholson AM, Russell R, Vermeulen L, Kemp R, Winton DJ.

Science. 2013 Nov 22;342(6161):995-8. Defining stem cell dynamics in models of intestinal tumour initiation. Vermeulen L, Morrissey E, van der Heijden M, Nicholson A, Sottoriva A, Buczacki S, Kemp R, Tavaré S, Winton DJ

The Journal of Experimental Medicine. 2018. Jul 2;215(7): 1891-1912 Itraconazole targets cell-cycle heterogeneity in colorectal cancer. Buczacki SJA, Popova S, Biggs E, Koukorava C, Buzzelli J, Vermeulen L, Hazelwood L, Francies H, Garnett MJ and Winton DJ