Dr Sakari Vanharanta
Dr Sakari Vanharanta is pleased to consider applications from prospective PhD students.
The majority of cancer-related deaths result from the spread of cancer to secondary organs in a phenomenon called metastasis. Recent advances have shown that systematic experimental approaches can identify key molecular drivers of metastasis. Still, in most cases metastatic cancer remains incurable. The vast majority of cancer cells that leave primary tumours die, making metastasis an extremely inefficient process. This suggests that disseminated cancer cells possess a number of vulnerabilities that could be targeted therapeutically. By using renal cell cancer as a model, this research programme aims at understanding how cancer cells acquire and maintain metastatic traits. The state-of-the-art multi-disciplinary approach combines functional genetics, experimental metastasis models, clinical association analysis, high-throughput genomics and bioinformatics in order to identify transcriptional regulators of metastatic cell states.
Symplectic Elements feed provided by Research Information, University of Cambridge