A hypercoagulable state leading to venous limb gangrene associated with occult lung adenocarcinoma

Clinical Case Reports - Robert Rintoul & David Gilligan

Abstract: We report a case of lung adenocarcinoma-associated hypercoagulability leading to venous limb gangrene, managed successfully with argatroban and then dabigatran. Use of idarucizumab permitted diagnostic investigations, leading to targeted antineoplastic therapy with crizotinib, surgical resection with curative intent, and continued survival over 2 years after the index event.

25 May 2019