Dr Marko Hyvonen
Position: Lecturer
Personal home page:
http://www-cryst.bioc.cam.ac.uk/groups/hyvonen
PubMed journal articles - click here
Dr Marko Hyvonen is pleased to consider applications from prospective PhD students.
We are using fragment based drug discovery methods to target a traditionally difficult class of drug targets, with emphasis on inhibition of protein-protein interactions critical to signalling proteins. We are also studying TGF-beta family growth factors, using biochemical, biophysical and structural biology approches to gain understanding on how they interact with regulatory proteins and receptors.
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G. Fischer, M. Rossmann, M. Hyvönen. Alternative Modulation of Protein-Protein Interactions by Small Molecules. Curr Opin in Biotech (2015), pp. 78-85 DOI: 10.1016/j.copbio.2015.04.006 D.E. Scott, A. G. Coyne, T. L. Blundell, A. Venkitaraman, C. Abell, M. Hyvönen, Small molecule inhibitors targeting protein-protein interaction in the RAD51 family of recombinases, ChemMedChem, DOI: 10.1002/cmdc.201402428, 2014 D. E. Scott, M. T. Ehebauer, T. Pukala, M. Marsh, T. L. Blundell, A. R. Venkitaraman, C. Abell, M. Hyvönen. Targeting the RAD51:BRCA2 Protein-Protein Interaction using Fragment-based methods. ChemBioChem 14(3):332-42, 2013 P Sled?, C. J. Stubbs, S. Lang, Y. Q. Yang, G. J. McKenzie, A. R. Venkitaraman, M. Hyvönen, C Abell. From crystal packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1. Angew Chem Int Ed Engl. 50:4003-6, 2011 A.E. Harrington, S.A. Morris-Triggs, B.T. Ruotolo, C.V. Robinson, S. Ohnuma and M. Hyvönen.. Structural basis for the inhibition of activin signalling by follistatin EMBO J, 25:1035-1045, 2006.