I am interested in determining how human cytomegalovirus and other intracellular pathogens evade innate immunity. We recently developed ?Quantitative Temporal Viromics?, a proteomic technique that provides a systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection. Applied to human cytomegalovirus infection, this technology provided a slew of novel data, detailing how HCMV orchestrates the expression of >8,000 cellular proteins to manipulate intrinsic, innate, and adaptive immune defences in addition to host signalling and metabolism. As well as a variety of novel innate and adaptive immune ligands, we identified viral proteins present early in infection at the cell surface, potential therapeutic targets. In addition to ongoing investigations into HCMV, I am also interested in other viral and non-viral systems, including the identification of cell surface markers of senescence in collaboration with Dr. Matthew Hoare at Cambridge CRUK.