Dr Feride (Ferda) Oezturk-Winder

University of Cambridge

University departments
Department of Genetics
University institutes
Wellcome Trust MRC Cambridge Stem Cell Institute

Position: Senior Research Associate
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Research description

My interest is in the characterisation of the biology of stem cells in normal lung and lung cancer, which should subsequently lead to an understanding of the initiation and progression of disease. My work is currently concentrated on the improvement of patient-specific 3D lung tissue culture in bioreactor systems. This work is important for both basic research and the development of potential therapeutic applications, such as individual specific drugs/drug combinations tailored for patients with lung cancer or other respiratory diseases.

Research Programme
Aerodigestive Cancer
Methods and technologies
Bioinformatics
Cell culture
Confocal microscopy
DNA sequencing
Fluorescence microscopy
Gene expression profiling
Imaging
Immunohistochemistry
In situ hybridization
In vivo modelling
Microscopy
Model organisms
PCR
Protein biochemistry
RNAi
Other
Tumour type interests
Lung
Other
Keywords

Stem cells
Progenitor cells
3D cell culture
Lineage tracing
Early cancer and Mouse models
Post transcriptional modifications

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Recent publications:
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Key publications

Guinot A, Oeztuerk-Winder F and Ventura JJ. (2016) miR-17-92/p38α dysregulation enhances Wnt signal and selects Lgr6+ cancer stem cell like cells during human lung adenocarcinoma progression Cancer Res. 2016; doi:10.1158/0008-5472.CAN-15-3302
Iwona Driskell, Feride Oeztuerk-Winder, Peter Humphreys and Michaela Frye (2014) Genetically induced cell death in bulge stem cells reveals their redundancy for hair and epidermal regeneration Stem Cells. 2014 Dec 2. 10.1002/stem.1910. PMID: 25447755
Ruiz EJ, Oeztuerk-Winder F and Ventura JJ. (2014) A paracrine network regulates the crosstalk between human lung stem cells and the stroma. Nat Commun. 2014 Jan 16;5:3175. PMID: 24430801.
Voisset E, Oeztuerk-Winder F, Ruiz EJ and Ventura JJ. (2013) p38α Negatively Regulates Survival and Malignant Selection of Transformed Bronchioalveolar Stem Cells. PLoS One. 12;8(11):e78911. PMID:
24265727.
Oeztuerk-Winder F, Guinot A, Ochalek A and Ventura JJ. (2012) Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/miR-17-92 axis. EMBO J 31(16):3431-41, PMID: 22828869.
Oeztuerk-Winder F and Ventura JJ. (2012) The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation. Biochem J 445(1):1-10, PMID: 22702973.
Oeztuerk-Winder F and Ventura JJ. (2012) Isolation, culture, and potentiality assessment of lung alveolar stem cells. Methods Mol Biol 916:23-30, PMID: 22914930.

Figure: Ex vivo 3D lung tumour model that has been shown to produce growing lung tumour nodules. Tumour cells seeded into decellularised lung scaffolds grew as 3D tumour nodules. Moreover, the human lung tumour cells developed a pattern of growth similar to the original human lung cancer. Unlike the in vitro 3D models, our ex vivo 3D lung model uses a natural matrix, which maintains its homology between species. This ex vivo model can be used potentially to gain a deeper understanding of the biologic processes involved in human lung cancer.