|
ABC-07 |
Addition of stereotactic radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers |
Dr Thankamma Ajithkumar |
31 Aug 2023 |
5 Apr 2017 |
Liver & Bile Duct |
|
ACTICCA-1 |
Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Observation After Curative Intent Resection of Biliary Tract Cancer |
Dr Pippa Corrie |
1 Apr 2020 |
22 Jun 2016 |
Liver & Bile Duct |
|
Add-Aspirin Trial |
A phase III, double blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours |
Dr Luke Hughes-Davies |
11 Dec 2020 |
21 Dec 2015 |
Breast, Colorectal, Oesophageal, Prostate |
|
ADSCaN |
A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-small Cell Lung Cancer |
Dr David Gilligan |
31 Dec 2021 |
23 Nov 2017 |
Lung |
|
ALF Research Study |
Research into Altered Lymphocyte Function in Health and Disease |
Dr Kate Fife |
31 Dec 2022 |
9 Nov 2017 |
Skin & melanoma |
|
ALL-RIC |
A comparison of reduced dose total body irradiation (TBI) and cyclophosphamide with fludarabine and melphalan reduced intensity conditioning in adults with acute lymphoblastic leukaemia (ALL) in complete remission |
Dr Ben Uttenthal |
30 Sep 2020 |
15 Mar 2019 |
Haematological |
|
AML 18 |
A Trial for Older Patients with Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome |
Dr Kiran Tawana |
31 Dec 2020 |
7 Dec 2015 |
Haematological |
|
AML 19 |
Adults with acute myeloid leukaemia or high-risk myelodysplastic syndrome |
Dr Kiran Tawana |
9 Nov 2021 |
15 Oct 2015 |
Haematological |
|
Ariel 4 (CANC 5651) |
A Phase 3 Multicenter, Open-label, Randomized Study of Rucaparib versus Chemotherapy in Patients with Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer |
Dr James Brenton |
11 Apr 2020 |
11 Apr 2017 |
Gynaecological |
|
Athena |
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy |
Dr Christine Parkinson |
31 Mar 2023 |
27 Mar 2019 |
Gynaecological |
|
ATOMIC-Meso |
Randomized, Double-Blind Phase 2/3 Study in Subjects with Malignant Pleural Mesothelioma with Low Argininosuccinate Synthetase 1 Expression to Assess ADI-PEG 20 with Pemetrexed and Cisplatin |
Dr David Gilligan |
25 Jan 2020 |
5 Mar 2018 |
Lung |
|
BRITER |
Brain Imaging to predict Toxicity in Elderly patients after Radiotherapy |
Dr Gary Doherty |
31 Mar 2021 |
10 Jan 2019 |
Brain and CNS |
|
Canopy-A |
Adjuvant canakinumab vs placebo in stages II-IIIB resected NSCLC |
Dr Gary Doherty |
30 Jun 2021 |
17 Apr 2019 |
Lung |
|
Cervical Cell Lift |
Collection of Cervical Cells at Colposcopy using a novel technique for analysis of high risk vs. low risk lesions |
Dr Robin Crawford |
31 Dec 2020 |
14 Jul 2017 |
Gynaecological |
|
COMBI-Aplus |
Open-label, phase IIIb study of dabrafenib in combination with trametinib in the adjuvant treatment of stage III BRAF V600 mutation-positive melanoma after complete resection to evaluate the impact on pyrexia related outcomes of an adapted pyrexia AE-management algorithm |
Dr Pippa Corrie |
31 Jul 2020 |
7 Sep 2018 |
Skin & melanoma |
|
Comice |
A randomized double blind placebo controlled Phase II clinical trial of Cediranib and Olaparib maintenance in advanced recurrent Cervical Cancer |
Dr Deborah Gregory |
31 Jan 2020 |
26 Jun 2019 |
Gynaecological |
|
CompARE Trial |
Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer |
Dr Rashmi Jadon |
31 Jan 2026 |
5 Mar 2019 |
Head & neck |
|
Cosmic 312 |
A Randomized, Controlled Phase 3 Study of Cabozantinib (XL184) in Combination with Atezolizumab versus Sorafenib in Subjects with Advanced Hepatocellular Carcinoma Who Have Not Received Previous Systemic Anticancer Therapy |
Dr Bristi Basu |
30 Sep 2020 |
21 Aug 2019 |
Liver & Bile Duct |
|
Dante |
A randomised phase III trial to evaluate the duration of anti-PD1 monoclonal antibody treatment in patients with metastatic melanoma |
Dr Pippa Corrie |
31 Mar 2023 |
21 Sep 2018 |
Skin & melanoma |
|
DIG (Diffusion imaging in gliomas) |
Quantitative diffusion imaging for early treatment response and progression evaluation in adult high grade gliomas; a multicentre study |
Dr Tomasz Matys |
31 Dec 2019 |
13 Jul 2018 |
Brain and CNS |
|
EMBRACE-II |
Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer |
Dr Li Tee Tan |
30 Jun 2024 |
7 Nov 2017 |
Gynaecological |
|
EuroNet-PHL-C2 |
Second International Inter-Group Study for Classical Hodgkin's Lymphoma in Children and Adolescents |
Dr Ben Uttenthal |
30 Sep 2021 |
30 Oct 2018 |
Haematological |
|
FIGHT 302 |
A Phase 3, Open-Label, Randomized, Active-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Gemcitabine Plus Cisplatin Chemotherapy in First-Line Treatment of Participants With Unresectable or Metastatic Cholangiocarcinoma With FGFR2 Rearrangement |
Dr Bristi Basu |
18 Oct 2021 |
4 Jul 2019 |
Liver & Bile Duct |
|
FLAIR |
Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab |
Dr George Follows |
4 Feb 2020 |
19 Jan 2015 |
Haematological |
|
FOCUS 4 |
FOCUS4 – Molecular selection of therapy in colorectal cancer: a molecularly stratified randomised controlled trials programme |
Dr Hugo Ford |
25 Nov 2020 |
1 Dec 2015 |
Colorectal |
|
HGUSStudy |
A randomized double-blind phase II study evaluating the role of maintenance therapy with cabozantinib in High Grade Undifferentiated Uterine Sarcoma (HGUS) after stabilization or response to doxorubicin +/- ifosfamide following surgery or in metastatic first line treatment |
Dr Helen Hatcher |
30 Dec 2019 |
11 Mar 2016 |
Sarcoma |
|
ICON8B |
A phase III randomised trial investigating the combination of dose-fractionated chemotherapy & bevacizumab compared to either strategy alone for the first line treatment of women with newly diagnosed high risk stage III-IV epithelial ovarian, fallopian tube or primary peritoneal cancer |
Dr Christine Parkinson |
31 Dec 2019 |
8 Feb 2012 |
Gynaecological |
|
innovaTIL-01 |
A Phase 2, Multicenter Study to Assess the Efficacy and Safety of Autologous Tumor Infiltrating Lymphocytes (LN-144) for Treatment of Patients with Metastatic Melanoma |
Dr Pippa Corrie |
31 Dec 2019 |
27 Jun 2018 |
Skin & melanoma |
|
IoN |
IoN Is ablative radio-iodine necessary for low risk differentiated thyroid cancer patients |
Dr Sarah Jefferies |
31 Dec 2019 |
28 Nov 2012 |
Head & neck |
|
IpiGlio |
A Phase II, open label, randomised study of ipilimumab with temozolomide versus temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma |
Dr Fiona Harris |
31 Jul 2020 |
21 Jan 2019 |
Brain and CNS |
|
Keynote 495 |
Phase 2 Precision Oncology Study of Biomarker-Directed, Pembrolizumab (MK-3475, SCH 900475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer |
Dr Gary Doherty |
31 May 2020 |
16 Apr 2019 |
Lung |
|
Keynote 775 |
A Multicenter, Open-label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib in Combination with Pembrolizumab Versus Treatment of Physician’s Choice in Participants with Advanced Endometrial Cancer |
Dr Christine Parkinson |
17 Oct 2020 |
17 Oct 2018 |
Gynaecological |
|
Keynote 937 |
Adjuvant Therapy with Pembrolizumab Versus Placebo in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection or Local Ablation |
Dr Bristi Basu |
30 Jun 2021 |
2 Aug 2019 |
Liver & Bile Duct |
|
LI-1 |
Leukaemia Lymphoma Research and NCRI Working Group Pick a Winner Programme (LI1) Trial |
Dr Jenny Craig |
31 Dec 2019 |
17 Feb 2014 |
Haematological |
|
MDS Registry for newly diagnosed patients |
A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes |
Professor Alan Warren |
1 May 2020 |
16 Feb 2009 |
Haematological |
|
MEASURES |
The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) |
Dr Anna Godfrey |
31 Dec 2020 |
12 Jul 2017 |
Haematological |
|
Mediola |
A Phase I/II Study of MEDI4736 (Anti-PD-L1 Antibody) in Combination with Olaparib (PARP inhibitor) in Patients with Advanced Solid Tumors |
Dr Christine Parkinson |
18 Oct 2020 |
18 Oct 2018 |
Gynaecological |
|
MelResist |
Investigating resistance to gene-targeted melanoma therapies |
Dr Pippa Corrie |
31 Dec 2021 |
3 Dec 2011 |
Skin & melanoma |
|
Minitub Registration Study (EORTC 1208) |
Prospective registry of Sentinel Node (SN) positive melanoma patients with minimal SN tumor burden who undergo Completion Lymph Node Dissection (CLND) or Nodal Observation |
Dr Amer Durrani |
1 May 2021 |
19 Oct 2017 |
Skin & melanoma |
|
MK3475-716 |
Adjuvant therapy with pembrolizumab versus placebo in resected stage II melanoma: a randomized, double-blind phase III study |
Dr Pippa Corrie |
31 Jul 2020 |
25 Oct 2018 |
Skin & melanoma |
|
MyeChild 01 |
International Randomised Phase III Clinical Trial in Children with Acute Myeloid Leukaemia - Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination with Induction Chemotherapy |
Dr Michael Gattens |
1 Nov 2021 |
31 Oct 2016 |
Haematological |
|
Myeloma XII |
A phase III study to determine the role of ixazomib as an Augmented Conditioning therapy in salvage autologous stem |
Dr Charles Crawley |
31 Dec 2021 |
22 May 2017 |
Haematological |
|
National Lung Matrix Trial |
Multi-drug, genetic marker-directed, non-comparative, multi-centre, multi-arm phase II trial in non-small cell lung cancer |
Dr David Gilligan |
31 Dec 2020 |
17 Nov 2015 |
Lung |
|
Neo-AEGIS |
Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction |
Dr Hugo Ford |
1 Sep 2020 |
24 Nov 2015 |
Oesophageal |
|
Neo-RT |
Pre-operative breast intensity modulated radiotherapy in patients receiving neo-adjuvant hormonal treatment for breast cancer – a feasibility study |
Dr Charlotte Coles |
14 Aug 2020 |
4 Dec 2017 |
Breast |
|
NKTR-214 and Nivolumab in melanoma patients |
A Phase 3, randomized, open-label study of NKTR-214 combined with nivolumab versus nivolumab alone in participants with previously untreated unresectable or metastatic melanoma |
Dr Pippa Corrie |
31 Aug 2020 |
30 Jul 2019 |
Skin & melanoma |
|
OPTIMA |
Optimal Personalised Treatment of early breast cancer using Multiparameter Analysis |
Dr Luke Hughes-Davies |
31 Oct 2020 |
25 Oct 2012 |
Breast |
|
PARADIGM Phase II |
Short-course radiotherapy plus olaparib for newly diagnosed glioblastoma in patients unsuitable for radical chemoradiation: a randomised phase II clinical trial preceded by a lead-in phase I dose escalation study |
Dr Sarah Jefferies |
30 Apr 2020 |
4 Nov 2016 |
Brain and CNS |
|
PARTNER |
Randomised, phase II/III, 3 stage trial to evaluate the safety and efficacy of the addition of olaparib to platinum-based neoadjuvant chemotherapy in breast cancer patients with TNBC and/or gBRCA |
Dr Jean Abraham |
31 Mar 2021 |
12 May 2016 |
Breast |
|
PATHOS |
A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer |
Dr Ekpemi Irune |
28 Feb 2020 |
16 Jun 2017 |
Head & neck |
|
PEACE |
The PEACE (Posthumous tissuE donAtion in CancEr) Study |
Dr James Brenton |
8 Oct 2020 |
8 Oct 2018 |
Gynaecological, Breast |
|
Pharmacyclics PCYC 1141 (Bruton's Tyrosine Kinase Inhibitor, Treatment for Follicular Lymphoma) |
A Multicentre, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton’s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination with Rituximab versus Placebo in Combination with Rituximab in Treatment Naïve Subjects with Follicular Lymphoma |
Dr George Follows |
16 Mar 2025 |
27 Jul 2018 |
Haematological |
|
Pioneer |
Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of letrozole plus PR agonist (Megestrol Acetate) versus letrozole aloNE in post-menopausal patients with ER-positive breast cancer |
Dr Richard Baird |
30 Jun 2020 |
20 Jul 2017 |
Breast |
|
PIVOTALboost |
A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost. |
Dr Yvonne Rimmer |
17 Aug 2020 |
7 Mar 2018 |
Prostate |
|
plasmaMATCH |
A multiple parallel cohort, non-randomised, open label, multi-centre phase IIa clinical trial aiming to provide proof of principle efficacy for designated targeted therapies in patients with advanced breast cancer where the targetable mutation is identified through ctDNA screening (Only cohort for Triple Negative Breast Cancer remains open) |
Dr Richard Baird |
31 Dec 2020 |
11 Apr 2017 |
Breast |
|
PLATO |
PersonaLising Anal cancer radioTherapy dOse |
Dr Catherine Jephcott |
31 Dec 2022 |
22 Mar 2017 |
Colorectal |
|
POPS |
A randomised phase II trial assessing Post-Operative use of ProSpare, a rectal obturator in prostate cancer radiotherapy |
Dr Yvonne Rimmer |
31 Dec 2019 |
4 Jul 2017 |
Prostate |
|
PRaM-GBM |
Predicting sites of tumour progression in the invasive margin of glioblastomas |
Mr Stephen Price |
31 Dec 2019 |
1 Feb 2017 |
Brain and CNS |
|
PRECISION-Panc |
Advancing personalised medicine treatment strategies for pancreatic cancer |
Dr Bristi Basu |
28 Feb 2023 |
25 Apr 2018 |
Pancreatic |
|
PRIMETIME |
Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers |
Dr Charlotte Coles |
31 Dec 2021 |
18 May 2017 |
Breast |
|
PRIMUS-001 |
An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation |
Dr Pippa Corrie |
30 Apr 2020 |
10 May 2018 |
Pancreatic |
|
PRISM |
A randomised phase II trial of nivolumab in combination with alternatively scheduled ipilimumab in first-line treatment of patients with advanced or metastatic renal cell carcinoma |
Dr Kate Fife |
31 Dec 2019 |
6 Jun 2018 |
Kidney |
|
Quality of Life After Bladder Cancer (Q-ABC) |
A comparison of patient related outcomes following radical surgery and radiotherapy |
Dr Yvonne Rimmer |
1 Mar 2022 |
23 Oct 2018 |
Bladder |
|
RAIDER |
A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder |
Dr Yvonne Rimmer |
31 Mar 2029 |
6 Jan 2016 |
Bladder |
|
RAMPART |
Renal Adjuvant MultiPle Arm Randomised Trial (RAMPART): An international investigator-led phase III multi-arm multi-stage multi-centre randomised-controlled platform trial of adjuvant therapy in patients with resected primary renal cell carcinoma (RCC) at high or intermediate risk of relapse |
Dr Sarah Welsh |
31 Dec 2023 |
20 Jul 2018 |
Kidney |
|
rEECur |
International randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma |
Dr Denise Williams |
30 Apr 2020 |
5 May 2016 |
Sarcoma |
|
RENA 4970 (The Water Study) |
Waterjet Ablation Therapy for Endoscopic Resection of prostate tissue |
Mr Tevita Aho |
30 Nov 2019 |
4 Feb 2016 |
Prostate |
|
ROAM |
Radiation versus observation following surgical resection of atypical meningioma: A randomised controlled trial |
Dr Sarah Jefferies |
30 Apr 2025 |
17 Nov 2016 |
Brain and CNS |
|
SARON |
Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial |
Dr Alex Martin |
4 Jul 2023 |
9 Aug 2017 |
Lung |
|
SCALOP-2 |
A multi-centre randomised study of induction chemotherapy followed by capecitabine (+/-nelfinavir) with high or standard dose radiotherapy for locally advanced non-metastatic pancreatic cancer |
Dr Thankamma Ajithkumar |
21 Mar 2020 |
18 Aug 2016 |
Pancreatic |
|
SCOPE-2 |
A randomised Phase II/III trial to study radiotherapy dose escalation in patients with oesophageal cancer treated with definitive chemoradiation with an embedded Phase II trial for patients with a poor early response using positron emission tomography (PET). |
Dr Susan Harden |
15 Aug 2020 |
28 Feb 2018 |
Oesophageal |
|
SEAL |
A Phase 2-3, multicenter, randomized, doubleblind study of selinexor (KPT-330) versus placebo in patients with advanced unresectable dedifferentiated liposarcoma (DDLS) |
Dr Helen Hatcher |
31 Aug 2020 |
7 Nov 2018 |
Sarcoma |
|
SHAPE |
A randomized phase III trial comparing radical hysterectomy and pelvic node dissection versus simple hysterectomy and pelvic node dissection in patients with low-risk early-stage cervical cancer |
Mr Robin Crawford |
11 Jan 2020 |
11 Jan 2016 |
Gynaecological |
|
SPECTA (EORTC 1553) |
Screening cancer patients for efficient clinical trial access |
Dr Helen Hatcher |
31 Dec 2021 |
1 Aug 2018 |
Sarcoma |
|
SSGXXII |
Three versus five years of adjuvant imatinib as treatment of patients with operable GIST with a high risk for recurrence: A randomised phase III study |
Dr Ramesh Bulusu |
31 Dec 2020 |
1 Mar 2017 |
Sarcoma |
|
STAMPEDE |
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy |
Dr Danish Mazhar |
6 Sep 2020 |
1 Aug 2018 |
Prostate |
|
Target Fal01 |
Translational Analysis and Research in Gynaecological Epithelial Tissues - Fallopian Tubes |
Dr Filipe Correia Martins |
30 Nov 2021 |
11 Jan 2019 |
Gynaecological |
|
The Causes of Clonal Blood Cell Disorders |
The Causes of Clonal Blood Cell Disorders |
Professor Tony Green |
31 Dec 2019 |
1 Jan 2008 |
Haematological |
|
Topaz |
A Phase III Randomized, Double-Blind Placebo Controlled, Multi-Regional, International Study of Durvalumab in Combination with Gemcitabine Plus Cisplatin Versus Placebo in Combination with Gemcitabine Plus Cisplatin for Patients With First-Line Advanced Biliary Tract Cancers |
Dr Pippa Corrie |
20 Nov 2020 |
18 Jun 2019 |
Liver & Bile Duct |
|
UK P3BEP Trial |
A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours |
Dr Danish Mazhar |
30 Jun 2020 |
5 May 2017 |
Testicular |
|
UKALL 14 |
A randomized trial for adults with newly diagnosed acute lymphoblastic leukaemia |
Dr Jenny Craig |
31 Dec 2019 |
31 Jul 2012 |
Haematological |
|
UTX-TGR-205 (Unity NHL) |
A Phase 2b Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + TGR-1202 with or without Bendamustine and TGR-1202 alone in Patients with Previously Treated Non-Hodgkin’s Lymphoma. |
Dr Dan Hodson |
29 Dec 2020 |
29 Dec 2017 |
Haematological |
|
Vestige |
Adjuvant immunotherapy in patients with resected gastric cancer following preoperative chemotherapy with high risk for recurrence (N+ and/or R1): an open label randomized controlled phase-2-study |
Dr Lizzie Smyth |
1 Aug 2020 |
16 Aug 2019 |
Oesophageal |
