Titlesort descending Trial description Contact name Trial end date Trial start date Trial tumour type
A Biomarker Study on Tumour Tissue in Patients with NSCLC A Biomarker Study on Tumour Tissue in Patients with NSCLC Dr Gary Doherty 28 Feb 2021 29 Jun 2020 Lung
ABC-07 Addition of stereotactic radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers Dr Thankamma Ajithkumar 31 Aug 2023 5 Apr 2017 Liver & Bile Duct
Add-Aspirin Trial A phase III, double blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours Dr Luke Hughes-Davies 11 Dec 2020 21 Dec 2015 Breast, Colorectal, Oesophageal, Prostate
ADSCaN A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-small Cell Lung Cancer Dr David Gilligan 31 Dec 2021 23 Nov 2017 Lung
ALF Research Study Research into Altered Lymphocyte Function in Health and Disease Dr Kate Fife 31 Dec 2022 9 Nov 2017 Skin & melanoma
Amadeus A Double-Blind, Phase III, Randomised Study to Compare the Efficacy and Safety of Oral Azacitidine (CC-486) Versus Placebo in Subjects with Acute Myeloid Leukaemia or Myelodysplastic Syndromes as Maintenance after Allogeneic Haematopoietic Stem Cell Transplantation Dr Charles Crawley 31 Dec 2022 19 Dec 2019 Haematological
AML 18 A Trial for Older Patients with Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome Dr Kiran Tawana 31 Dec 2020 7 Dec 2015 Haematological
AMPLIFY A Randomized, Multicenter, Open-Label, Phase 3 Study to Compare the Efficacy and Safety of Acalabrutinib (ACP-196) in Combination with Venetoclax with and without Obinutuzumab Compared to Investigator’s Choice of Chemoimmunotherapy in Subjects with Previously Untreated Chronic Lymphocytic Leukemia Without del(17p) or TP53 Mutation. Dr George Follows 28 Feb 2021 13 Oct 2020 Haematological
Ariel 4 (CANC 5651) A Phase 3 Multicenter, Open-label, Randomized Study of Rucaparib versus Chemotherapy in Patients with Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Dr James Brenton 30 Dec 2020 11 Apr 2017 Gynaecological
ATOMIC-Meso Randomized, Double-Blind Phase 2/3 Study in Subjects with Malignant Pleural Mesothelioma with Low Argininosuccinate Synthetase 1 Expression to Assess ADI-PEG 20 with Pemetrexed and Cisplatin Dr David Gilligan 30 Dec 2020 5 Mar 2018 Lung
BEAT-meso A multicentre randomised phase III trial comparing atezolizumab plus bevacizumab and standard chemotherapy versus bevacizumab and standard chemotherapy as first-line treatment for advanced malignant pleural mesothelioma Dr David Gilligan 15 Jan 2025 5 Sep 2019 Lung
Best-Of Phase III study assessing the "Best-Of" radiotherapy compared to the "Best-Of" surgery (trans-oral surgery (TOS) in patients with T1-T2, N0 oropharyngeal carcinoma Dr Ekpemi Irune 1 Jan 2026 17 Nov 2020 Head & neck
BRITER Brain Imaging to predict Toxicity in Elderly patients after Radiotherapy Dr Gary Doherty 31 Mar 2021 10 Jan 2019 Brain and CNS
Canopy-A Adjuvant canakinumab vs placebo in stages II-IIIB resected NSCLC Dr Gary Doherty 30 Jun 2021 17 Apr 2019 Lung
Cervical Cell Lift Collection of Cervical Cells at Colposcopy using a novel technique for analysis of high risk vs. low risk lesions Dr Robin Crawford 31 Dec 2020 14 Jul 2017 Gynaecological
CHIRON An Open-Label, Multi-Centre Phase I/IIa Study Evaluating the Safety and Clinical Activity of Neoantigen Reactive T cells in Patients with Advanced Non-Small Cell Lung Cancer Dr Gary Doherty 31 Oct 2021 21 Jan 2020 Lung
CompARE Trial Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer Dr Rashmi Jadon 31 Jan 2026 5 Mar 2019 Head & neck
COSI An International Randomised Clinical Trial of Therapeutic Interventions with the Potential to Improve Outcome in Adults with Acute Myeloid Leukaemia and High Risk Myelodysplasia Undergoing Allogeneic Stem Cell Transplantation Dr Charles Crawley 1 Apr 2025 9 Sep 2020 Haematological
COSMIC-313 A Randomized, Double-Blind, Controlled Phase 3 Study of Cabozantinib in Combination with Nivolumab and Ipilimumab versus Nivolumab and Ipilimumab in Subjects with Previously Untreated Advanced or Metastatic Renal Cell Carcinoma of Intermediate or Poor Risk Dr Kate Fife 31 Dec 2025 6 Dec 2019 Kidney
Dante A randomised phase III trial to evaluate the duration of anti-PD1 monoclonal antibody treatment in patients with metastatic melanoma Dr Pippa Corrie 31 Mar 2023 21 Sep 2018 Skin & melanoma
DIG (Diffusion imaging in gliomas) Quantitative diffusion imaging for early treatment response and progression evaluation in adult high grade gliomas; a multicentre study Dr Tomasz Matys 31 Dec 2022 13 Jul 2018 Brain and CNS
DS8201-A-U205 (Daiichi) A phase 2, open-label, single-arm trial of Trastuzumab Deruxtecan (DS-8201A) in HER2-positive, unresectable ormetastatic gastric or gastro-esophageal junction (GEJ) adenocarcinoma subjects who have progressed on or after a Trastuzumab containing regime Dr Lizzie Smyth 1 Apr 2022 13 Dec 2019 Oesophageal
EMBRACE-II Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer Dr Li Tee Tan 30 Jun 2024 7 Nov 2017 Gynaecological
EMT2 A randomised placebo-controlled phase III trial of the effect of the omega-3 fatty acid eicosapentaenoic acid (EPA) on colorectal cancer recurrence and survival after surgery for resectable liver metastases Dr Lizzie Smyth 31 Jul 2021 30 Oct 2019 Colorectal
EuroNet-PHL-C2 Second International Inter-Group Study for Classical Hodgkin's Lymphoma in Children and Adolescents Dr Ben Uttenthal 30 Sep 2021 30 Oct 2018 Haematological
FIGHT 302 A Phase 3, Open-Label, Randomized, Active-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Gemcitabine Plus Cisplatin Chemotherapy in First-Line Treatment of Participants With Unresectable or Metastatic Cholangiocarcinoma With FGFR2 Rearrangement Dr Bristi Basu 18 Oct 2021 4 Jul 2019 Liver & Bile Duct
FLAURA-2 A phase III, open-label, randomized study of osimertinib with or without platinum plus pemetrexed chemotherapy, as first-line treatment in patients with epidermal growth factor receptor (EGFR) mutation-positive, locally advanced or metastatic non-small cell lung cancer (FLAURA-2) Dr Gary Doherty 23 Mar 2026 25 Sep 2020 Lung
Hamlet.rt (H&N) Hamlet.rt - Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy Dr Raj Jena 31 Oct 2021 24 Oct 2019 Head & neck
Hamlet.rt (Prostate) Hamlet.rt - Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy Dr Raj Jena 31 Oct 2021 24 Oct 2019 Prostate
ICI Genetics Identification of genetic factors that predispose to immune checkpoint inhibitor toxicity’ Dr Gary Doherty 14 Feb 2021 12 Apr 2019 Lung
ICONIC Improving outcomes through collaboration in osteosarcoma Dr Han Wong 30 Sep 2022 13 Dec 2019 Sarcoma
KEYLYNK-010 A Phase 3, Randomized Open-label Study of Pembrolizumab (MK-3475) Plus Olaparib Versus Abiraterone Acetate or Enzalutamide in Participants with Metastatic Castrationresistant Prostate Cancer (mCRPC) Who are Unselected for Homologous Recombination Repair Defects and Have Failed Prior Treatment with One Next generation Hormonal Agent (NHA) and Chemotherapy  Dr Danish Mazhar 30 Dec 2020 24 Sep 2019 Prostate
Keynote 937 Adjuvant Therapy with Pembrolizumab Versus Placebo in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection or Local Ablation Dr Bristi Basu 30 Jun 2021 2 Aug 2019 Liver & Bile Duct
KEYNOTE-641 A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) Dr Danish Mazhar 30 Apr 2024 8 Oct 2019 Prostate
KEYNOTE-921 A Phase 3, Randomized, Double-blind Study of Pembrolizumab (MK-3475) Plus Docetaxel Plus Prednisone versus Placebo Plus Docetaxel Plus Prednisone in Participants with Chemotherapy-naïve Metastatic Castration-Resistant Prostate Cancer (mCRPC) who have Progressed on a Next Generation Hormonal Agent (NHA) Dr Danish Mazhar 30 Dec 2020 24 Sep 2019 Prostate
LEAP-006 A Phase 3 Randomized, Placebo-controlled Study to Evaluate the Safety and Efficacy of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) with or without Lenvatinib (E7080/MK-7902) as First-line Intervention in Participants with Metastatic Nonsquamous Non-small Cell Lung Cancer (LEAP-006) Dr Gary Doherty 30 Sep 2024 18 Sep 2020 Lung
LI-1 Leukaemia Lymphoma Research and NCRI Working Group Pick a Winner Programme (LI1) Trial Dr Jenny Craig 31 Dec 2021 17 Feb 2014 Haematological
LI-1 - AML LI (less intensive)-1 will evaluate several relevent therapeutic questions in Acute Myeloid Leukemia (AML) as defined by the WHO and High-Risk Myelodysplastic Syndrome. The trial is primarily designed for patients ver 60 years for whom conventional chemotherapy is not considered suitable. The trial is part of a continuous program of developement aimed at improving the outcomes of treatment in this patient population Dr Kiran Tawana 31 Dec 2020 17 Feb 2014 Haematological
MelResist Investigating resistance to gene-targeted melanoma therapies Dr Pippa Corrie 31 Dec 2021 3 Dec 2011 Skin & melanoma
Minitub Registration Study (EORTC 1208)  Prospective registry of Sentinel Node (SN) positive melanoma patients with minimal SN tumor burden who undergo Completion Lymph Node Dissection (CLND) or Nodal Observation Dr Amer Durrani 1 May 2021 19 Oct 2017 Skin & melanoma
MITRE Microbiome Immunotherapy Toxicity and Response Evaluation (MITRE) An observational study to evaluate the microbiome as a biomarker of efficacy and toxicity in cancer patients receiving immune checkpoint inhibitor therapy Dr Pippa Corrie 31 Dec 2024 30 Mar 2021 Kidney, Lung, Skin & melanoma
MyeChild 01 International Randomised Phase III Clinical Trial in Children with Acute Myeloid Leukaemia - Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination with Induction Chemotherapy Dr Michael Gattens 1 Nov 2021 31 Oct 2016 Haematological
Myeloma XII A phase III study to determine the role of ixazomib as an Augmented Conditioning therapy in salvage autologous stem Dr Charles Crawley 31 Dec 2021 22 May 2017 Haematological
National Lung Matrix Trial Multi-­drug, genetic marker-directed, non­-comparative, multi-­centre, multi­-arm phase II trial in non-small cell lung cancer Dr David Gilligan 31 Dec 2020 17 Nov 2015 Lung
PACE-C International randomised study of prostatectomy vs stereotactic body radiotherapy (SBRT) and conventional radiotherapy vs SBRT for organ-confined prostate cancer Dr Alex Martin 26 Apr 2026 5 Feb 2020 Prostate
PARTNER Randomised, phase II/III, 3 stage trial to evaluate the safety and efficacy of the addition of olaparib to platinum-based neoadjuvant chemotherapy in breast cancer patients with TNBC and/or gBRCA Dr Jean Abraham 31 Mar 2021 12 May 2016 Breast
PATHOS A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer Dr Ekpemi Irune 31 Dec 2021 16 Jun 2017 Head & neck
Pharmacyclics PCYC 1141 (Bruton's Tyrosine Kinase Inhibitor, Treatment for Follicular Lymphoma) A Multicentre, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton’s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination with Rituximab versus Placebo in Combination with Rituximab in Treatment Naïve Subjects with Follicular Lymphoma Dr George Follows 16 Mar 2025 27 Jul 2018 Haematological
Pioneer Randomised Phase II clinical trial PIONEER- A Pre-operative wIndOw study of letrozole plus PR agonist (Megestrol Acetate) versus letrozole aloNE in post-menopausal patients with ER-positive breast cancer Dr Richard Baird 31 Dec 2020 20 Jul 2017 Breast
PIVOTALboost A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost. Dr Yvonne Rimmer 17 Aug 2021 7 Mar 2018 Prostate
plasmaMATCH A multiple parallel cohort, non-randomised, open label, multi-centre phase IIa clinical trial aiming to provide proof of principle efficacy for designated targeted therapies in patients with advanced breast cancer where the targetable mutation is identified through ctDNA screening (Only cohort for Triple Negative Breast Cancer remains open) Dr Richard Baird 31 Dec 2020 11 Apr 2017 Breast
PLATO PersonaLising Anal cancer radioTherapy dOse Dr Catherine Jephcott 31 Dec 2022 22 Mar 2017 Colorectal
POPS A randomised phase II trial assessing Post-Operative use of ProSpare, a rectal obturator in prostate cancer radiotherapy Dr Yvonne Rimmer 31 Dec 2021 4 Jul 2017 Prostate
PORTICO SABR Pre-operative stereotactic ablative body radiotherapy followed by immediate surgery in pancreatic adenocarcinoma: A window of opportunity feasibility study Dr Thankamma Ajithkumar 16 Jun 2021 26 Oct 2020 Pancreatic
PORTICOtrans PORTICOtrans: A feasibility study to evaluate the immune-milieu in patients undergoing Whipple’s resection, comparing the utility of trans-duodenal biopsy, frozen and FFPE resection specimens Dr Duncan Jodrell 26 Jun 2021 10 Oct 2019 Pancreatic
PRaM-GBM Predicting sites of tumour progression in the invasive margin of glioblastomas Mr Stephen Price 31 Dec 2020 1 Feb 2017 Brain and CNS
PRECISION-Panc Advancing personalised medicine treatment strategies for pancreatic cancer Dr Bristi Basu 28 Feb 2023 25 Apr 2018 Pancreatic
PRIMETIME Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers Dr Charlotte Coles 31 Dec 2021 18 May 2017 Breast
PRIMUS-001 An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation Dr Pippa Corrie 30 Apr 2022 10 May 2018 Pancreatic
Quality of Life After Bladder Cancer (Q-ABC) A comparison of patient related outcomes following radical surgery and radiotherapy Dr Yvonne Rimmer 1 Mar 2022 23 Oct 2018 Bladder
RAMPART Renal Adjuvant MultiPle Arm Randomised Trial (RAMPART): An international investigator-led phase III multi-arm multi-stage multi-centre randomised-controlled platform trial of adjuvant therapy in patients with resected primary renal cell carcinoma (RCC) at high or intermediate risk of relapse Dr Sarah Welsh 31 Dec 2023 20 Jul 2018 Kidney
rEECur International randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma Dr Han Wong 30 Sep 2022 5 May 2016 Sarcoma
ROAM Radiation versus observation following surgical resection of atypical meningioma: A randomised controlled trial Dr Sarah Jefferies 30 Apr 2025 17 Nov 2016 Brain and CNS
SARON Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial Dr Alex Martin 4 Jul 2023 9 Aug 2017 Lung
SKYSCRAPER-07 A phase III randomised , double-blind, placebo-controlled study of Atezolizumab with or without Tiragolumab (anti-tigit antibody) in patients with locally advanced esophageal squamous cell carcinoma Dr Lizzie Smyth 31 Dec 2025 17 Nov 2020 Oesophageal
SPECTA (EORTC 1553) Screening cancer patients for efficient clinical trial access Dr Sarah Welsh 31 Dec 2021 1 Aug 2018 Kidney
SPECTA (EORTC 1553) (Sarcoma) Screening cancer patients for efficient clinical trial access Dr Helen Hatcher 31 Dec 2021 1 Aug 2018 Sarcoma
SPECTA (EORTC 1553) (Skin & Melanoma) Screening cancer patients for efficient clinical trial access Dr Kate Fife 31 Dec 2021 1 Aug 2018 Skin & melanoma
Spotlight A Phase 3, Global, Multi-Centre, Double-Blind, Randomised, Efficacy Study of IMAB362 Plus mFOLFOX6 Compared with Placebo Plus mFOLFOX6 as First-line Treatment of Subjects with Claudin (CLDN)18.2-Positive, HER2-Negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma Dr Lizzie Smyth 14 Feb 2022 4 Sep 2020 Oesophageal
SPRING Seizure prophylaxis in Glioma Mr Stephen Price 31 May 2023 11 Dec 2019 Brain and CNS
SSGXXII Three versus five years of adjuvant imatinib as treatment of patients with operable GIST with a high risk for recurrence: A randomised phase III study Dr Ramesh Bulusu 31 Dec 2020 1 Mar 2017 Sarcoma
Target Fal01 Translational Analysis and Research in Gynaecological Epithelial Tissues - Fallopian Tubes Dr Filipe Correia Martins 30 Nov 2021 11 Jan 2019 Gynaecological
UK P3BEP Trial A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours Dr Danish Mazhar 30 Dec 2020 5 May 2017 Testicular
WIRE Window-of-opportunity clinical trials platform for evaluation of novel treatment strategies in renal cell cancer Dr Sarah Welsh 6 Jun 2023 22 Jul 2020 Kidney