Titlesort descending Trial description Contact name Trial end date Trial start date Trial tumour type
ABC-07 Addition of stereotactic radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers Dr Thankamma Ajithkumar 31 Aug 2023 5 Apr 2017 Liver & Bile Duct
Add-Aspirin Trial A phase III, double blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours Dr Luke Hughes-Davies 11 Dec 2021 21 Dec 2015 Breast, Colorectal, Oesophageal, Prostate
ADSCaN A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-small Cell Lung Cancer Dr David Gilligan 31 Dec 2021 23 Nov 2017 Lung
ALF Research Study Research into Altered Lymphocyte Function in Health and Disease Dr Kate Fife 31 Dec 2022 9 Nov 2017 Skin & melanoma
Amadeus A Double-Blind, Phase III, Randomised Study to Compare the Efficacy and Safety of Oral Azacitidine (CC-486) Versus Placebo in Subjects with Acute Myeloid Leukaemia or Myelodysplastic Syndromes as Maintenance after Allogeneic Haematopoietic Stem Cell Transplantation Dr Charles Crawley 31 Dec 2022 19 Dec 2019 Haematological
BEAT-meso A multicentre randomised phase III trial comparing atezolizumab plus bevacizumab and standard chemotherapy versus bevacizumab and standard chemotherapy as first-line treatment for advanced malignant pleural mesothelioma Dr David Gilligan 15 Jan 2025 5 Sep 2019 Lung
Best-Of Phase III study assessing the "Best-Of" radiotherapy compared to the "Best-Of" surgery (trans-oral surgery (TOS) in patients with T1-T2, N0 oropharyngeal carcinoma Dr Ekpemi Irune 1 Jan 2026 17 Nov 2020 Head & neck
CHIRON An Open-Label, Multi-Centre Phase I/IIa Study Evaluating the Safety and Clinical Activity of Neoantigen Reactive T cells in Patients with Advanced Non-Small Cell Lung Cancer Dr Gary Doherty 31 Oct 2021 21 Jan 2020 Lung
CompARE Trial Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer Dr Rashmi Jadon 31 Jan 2026 5 Mar 2019 Head & neck
COSI An International Randomised Clinical Trial of Therapeutic Interventions with the Potential to Improve Outcome in Adults with Acute Myeloid Leukaemia and High Risk Myelodysplasia Undergoing Allogeneic Stem Cell Transplantation Dr Charles Crawley 1 Apr 2025 9 Sep 2020 Haematological
COSMIC-313 A Randomized, Double-Blind, Controlled Phase 3 Study of Cabozantinib in Combination with Nivolumab and Ipilimumab versus Nivolumab and Ipilimumab in Subjects with Previously Untreated Advanced or Metastatic Renal Cell Carcinoma of Intermediate or Poor Risk Dr Kate Fife 31 Dec 2025 6 Dec 2019 Kidney
Dante A randomised phase III trial to evaluate the duration of anti-PD1 monoclonal antibody treatment in patients with metastatic melanoma Dr Pippa Corrie 31 Mar 2023 21 Sep 2018 Skin & melanoma
DIG (Diffusion imaging in gliomas) Quantitative diffusion imaging for early treatment response and progression evaluation in adult high grade gliomas; a multicentre study Dr Tomasz Matys 31 Dec 2022 13 Jul 2018 Brain and CNS
DS8201-A-U205 (Daiichi) A phase 2, open-label, single-arm trial of Trastuzumab Deruxtecan (DS-8201A) in HER2-positive, unresectable ormetastatic gastric or gastro-esophageal junction (GEJ) adenocarcinoma subjects who have progressed on or after a Trastuzumab containing regime Dr Lizzie Smyth 1 Apr 2022 13 Dec 2019 Oesophageal
EMBRACE-II Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer Dr Li Tee Tan 30 Jun 2024 7 Nov 2017 Gynaecological
FIGHT 302 A Phase 3, Open-Label, Randomized, Active-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Gemcitabine Plus Cisplatin Chemotherapy in First-Line Treatment of Participants With Unresectable or Metastatic Cholangiocarcinoma With FGFR2 Rearrangement Dr Bristi Basu 18 Oct 2021 4 Jul 2019 Liver & Bile Duct
FLAURA-2 A phase III, open-label, randomized study of osimertinib with or without platinum plus pemetrexed chemotherapy, as first-line treatment in patients with epidermal growth factor receptor (EGFR) mutation-positive, locally advanced or metastatic non-small cell lung cancer (FLAURA-2) Dr Gary Doherty 23 Mar 2026 25 Sep 2020 Lung
Hamlet.rt (H&N) Hamlet.rt - Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy Dr Raj Jena 31 Oct 2021 24 Oct 2019 Head & neck
Hamlet.rt (Prostate) Hamlet.rt - Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy Dr Raj Jena 31 Oct 2021 24 Oct 2019 Prostate
ICONIC Improving outcomes through collaboration in osteosarcoma Dr Han Wong 30 Sep 2022 13 Dec 2019 Sarcoma
KEYNOTE-641 A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) Dr Danish Mazhar 30 Apr 2024 8 Oct 2019 Prostate
LEAP-006 A Phase 3 Randomized, Placebo-controlled Study to Evaluate the Safety and Efficacy of Pemetrexed + Platinum Chemotherapy + Pembrolizumab (MK-3475) with or without Lenvatinib (E7080/MK-7902) as First-line Intervention in Participants with Metastatic Nonsquamous Non-small Cell Lung Cancer (LEAP-006) Dr Gary Doherty 30 Sep 2024 18 Sep 2020 Lung
LI-1 Leukaemia Lymphoma Research and NCRI Working Group Pick a Winner Programme (LI1) Trial Dr Jenny Craig 31 Dec 2021 17 Feb 2014 Haematological
MelResist Investigating resistance to gene-targeted melanoma therapies Dr Pippa Corrie 31 Dec 2021 3 Dec 2011 Skin & melanoma
MITRE Microbiome Immunotherapy Toxicity and Response Evaluation (MITRE) An observational study to evaluate the microbiome as a biomarker of efficacy and toxicity in cancer patients receiving immune checkpoint inhibitor therapy Dr Pippa Corrie 31 Dec 2024 30 Mar 2021 Kidney, Lung, Skin & melanoma
MONITOR Multi-centre Observational study of maintenance Nirparib in Treatment of Ovarian CanceR: UK routine clinical practice experience      Dr Joo Ern Ang 3 Jan 2022 14 Oct 2020 Gynaecological
MyeChild 01 International Randomised Phase III Clinical Trial in Children with Acute Myeloid Leukaemia - Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination with Induction Chemotherapy Dr Michael Gattens 1 Nov 2021 31 Oct 2016 Haematological
Myeloma XII A phase III study to determine the role of ixazomib as an Augmented Conditioning therapy in salvage autologous stem Dr Charles Crawley 31 Dec 2021 22 May 2017 Haematological
OPTIMA Optimal Personalised Treatment of early breast cancer using Multiparameter Analysis Dr Luke Hughes-Davies 31 Oct 2021 25 Oct 2012 Breast
PACE-C International randomised study of prostatectomy vs stereotactic body radiotherapy (SBRT) and conventional radiotherapy vs SBRT for organ-confined prostate cancer Dr Alex Martin 26 Apr 2026 5 Feb 2020 Prostate
PATHOS A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer Dr Ekpemi Irune 31 Dec 2021 16 Jun 2017 Head & neck
Pharmacyclics PCYC 1141 (Bruton's Tyrosine Kinase Inhibitor, Treatment for Follicular Lymphoma) A Multicentre, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton’s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination with Rituximab versus Placebo in Combination with Rituximab in Treatment Naïve Subjects with Follicular Lymphoma Dr George Follows 16 Mar 2025 27 Jul 2018 Haematological
PLATO PersonaLising Anal cancer radioTherapy dOse Dr Catherine Jephcott 31 Dec 2022 22 Mar 2017 Colorectal
POPS A randomised phase II trial assessing Post-Operative use of ProSpare, a rectal obturator in prostate cancer radiotherapy Dr Yvonne Rimmer 31 Dec 2021 4 Jul 2017 Prostate
PRECISION-Panc Advancing personalised medicine treatment strategies for pancreatic cancer Dr Bristi Basu 28 Feb 2023 25 Apr 2018 Pancreatic
PRIMETIME Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers Dr Charlotte Coles 31 Dec 2021 18 May 2017 Breast
PRIMUS-001 An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation Dr Pippa Corrie 30 Apr 2022 10 May 2018 Pancreatic
Quality of Life After Bladder Cancer (Q-ABC) A comparison of patient related outcomes following radical surgery and radiotherapy Dr Yvonne Rimmer 1 Mar 2022 23 Oct 2018 Bladder
RAMPART Renal Adjuvant MultiPle Arm Randomised Trial (RAMPART): An international investigator-led phase III multi-arm multi-stage multi-centre randomised-controlled platform trial of adjuvant therapy in patients with resected primary renal cell carcinoma (RCC) at high or intermediate risk of relapse Dr Sarah Welsh 31 Dec 2023 20 Jul 2018 Kidney
rEECur International randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma Dr Han Wong 30 Sep 2022 5 May 2016 Sarcoma
ROAM Radiation versus observation following surgical resection of atypical meningioma: A randomised controlled trial Dr Sarah Jefferies 30 Apr 2025 17 Nov 2016 Brain and CNS
Ruby A Phase 3, Randomized, Double-blind, Multicenter Study of Dostarlimab (TSR-042) plus Carboplatin-Paclitaxel versus Placebo plus Carboplatin-Paclitaxel in Patients with Recurrent or Primary Advanced Endometrial Cancer Dr Joo Ern Ang 18 May 2023 26 Nov 2020 Gynaecological
SARON Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial Dr Alex Martin 4 Jul 2023 9 Aug 2017 Lung
SKYSCRAPER-07 A phase III randomised , double-blind, placebo-controlled study of Atezolizumab with or without Tiragolumab (anti-tigit antibody) in patients with locally advanced esophageal squamous cell carcinoma Dr Lizzie Smyth 31 Dec 2025 17 Nov 2020 Oesophageal
SPECTA (EORTC 1553) Screening cancer patients for efficient clinical trial access Dr Sarah Welsh 31 Dec 2021 1 Aug 2018 Kidney
SPECTA (EORTC 1553) (Sarcoma) Screening cancer patients for efficient clinical trial access Dr Helen Hatcher 31 Dec 2021 1 Aug 2018 Sarcoma
SPECTA (EORTC 1553) (Skin & Melanoma) Screening cancer patients for efficient clinical trial access Dr Kate Fife 31 Dec 2021 1 Aug 2018 Skin & melanoma
Spotlight A Phase 3, Global, Multi-Centre, Double-Blind, Randomised, Efficacy Study of IMAB362 Plus mFOLFOX6 Compared with Placebo Plus mFOLFOX6 as First-line Treatment of Subjects with Claudin (CLDN)18.2-Positive, HER2-Negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma Dr Lizzie Smyth 14 Feb 2022 4 Sep 2020 Oesophageal
SPRING Seizure prophylaxis in Glioma Mr Stephen Price 31 May 2023 11 Dec 2019 Brain and CNS
Target Fal01 Translational Analysis and Research in Gynaecological Epithelial Tissues - Fallopian Tubes Dr Filipe Correia Martins 30 Nov 2021 11 Jan 2019 Gynaecological
WIRE Window-of-opportunity clinical trials platform for evaluation of novel treatment strategies in renal cell cancer Dr Sarah Welsh 6 Jun 2023 22 Jul 2020 Kidney