The Neuro-Oncology Programme is a network of researchers and clinicians in Cambridge working in brain tumour research. Research is focused on understanding the different types of brain tumours that develop in both adults and children, finding the most effective ways of diagnosing brain tumours as early as possible, developing new treatments and monitoring how tumours are responding to treatment.

Over 11,000 people are diagnosed with new cases of brain or central nervous system (CNS) cancer every year in the UK, and brain tumours have been defined as a cancer of unmet need

Connecting brain and CNS cancer researchers in Cambridge
Brain tumours and COVID-19

Adult and Paediatric Guidelines from the British Neuro-oncology Society

Guidance for patients from The Brain Tumour Charity

CovidSurg Cancer Study - collecting data on cancer patients requiring surgery

Group Leader - Dr Manav Pathania

Combining developmental neurobiology, epigenetics, stem cell science and genomic approaches, the Pathania group looks to reveal the role of chromatin remodelling in paediatric high-grade glioma.

Rohit Sinha, Clinical Research Fellow
Clinical Research Fellow profile

Rohit Sinha, who started his Clinical Research Fellowship in 2017 explains his research and why he applied to the CRUK Cambridge Centre for a clinical fellowship.

Cancer Research UK Children’s Brain Tumour Centre of Excellence

The Cancer Research UK Children’s Brain Tumour Centre of Excellence (CRUK-CBTCE) brings together teams at the University of Cambridge and the Institute of Cancer Research (ICR) to revolutionise the approach to research and treatment of paediatric brain tumours, drawing on the host institutions' strengths in therapeutic discovery.


To forge an innovative four-stage pipeline that generates curative treatments for children with brain tumours.


To transform the way, the world develops treatments for children with brain tumours.

The research strategy for the CRUK-CBTCE is centred on their biology, drug discovery and development pipeline, which will leverage the expertise of the brightest minds in the paediatric brain tumour field. For more information on the CRUK-CBTCE, please visit their website.

Tessa Jowell Brain Cancer Mission

Following Tessa Jowell’s call for action to improve brain tumour treatment, research and survival, the Tessa Jowell Brain Cancer Mission (TJBCM) was formed. The mission consists of passionate academics, doctors, members of cancer charities, patients, and other individuals to help facilitate a new national strategy for brain tumours.

The TJBCM serves as a convening body for these organisations, enabling them to work together to make a tangible change in brain tumour treatment and research. TJBCM is neither a charity, fundraising nor grant-awarding body.

Over the next five years the TJBCM is focusing on six strategic objectives, organised through individual Strategic Programmes. These initiatives are:

  • Patients
  • Clinical trials
  • Training for physicians
  • Research
  • Emerging data and technology
  • Tessa Jowell Centre Designation
Using dyes to guide surgery

The Centre is coordinating a number of clinical trials for adults and children with cancer of the brain or spinal cord. One of these trials is testing a new tool to help surgeons remove as much of brain tumour as possible and potentially improve the survival rates of patients. Patients with glioblastoma are given a drink, which makes the tumour cells glow pink under ultra-violet light. This allows the surgeon to distinguish tumour from normal brain allowing more tumour to be removed while improving patient safety. Discs with a drug that kills tumour cells are then implanted in the space left after the tumour has been removed, to target any tumour cells left behind.

Tumour heterogeneity, growth and evolution

We have recently developed a real-time multiple sampling scheme to interrogate high-grade glioma during surgery. FGMS (Fluorescence-Guided Multiple Sampling) is based on fluorescence-guided resection technology to obtain spatially distinct tumour biopsies from individual tumours in real time, during cytoreductive surgery. We can use these data to dissect intra-tumour heterogeneity, identify clonal diversity and infer tumour evolution. Little is known about the impact of intra-tumour heterogeneity on tumour evolution, growth and the consequences of such heterogeneity on the emergence of resistant disease. This is an important problem in brain tumour research because it is the emergence of recurrent treatment-resistant disease that kills patients and it is variability in this biological process that is responsible for variation between individual patients.

Developing biomarkers for detection, diagnosis and treatment response

The Cambridge Cancer Centre is developing novel imaging biomarkers, suitable for use in routine clinical practice, which will identify disease instability and monitor and predict treatment response. A new collaborative EPSRC/CRUK-funded strategic programme undertaken in conjunction with the Manchester Cancer Research Centre has established the CRUK & EPSRC Cancer Imaging Centre in Cambridge & Manchester to develop ‘imaging signatures’ of different tumours and their response to treatment. The challenge is to reliably identify ‘imaging signatures’ that reproducibly identify pathological processes such as cell proliferation or brain invasion. This will have a major impact on the development of improved non-invasive techniques for diagnosis, treatment, identification of early treatment response and early detection of tumour resistance.We are also developing biomarkers for use during operations to help surgeons remove cancer cells more effectively and safely. This will help radiotherapy and chemotherapy to work more effectively to improve patient survival.

Developing better treatments for patients with brain cancer

To date, novel treatments for glioblastoma have mainly been developed in conventional, established glioma cell culture systems then tested in small animal models in vivo. With the exception of temozolomide, these treatments have uniformly failed to improve outcomes in the clinic. We propose that these models are inadequate and generate misleading data. The objective of the CRUK Cambridge Centre is to establish and validate novel models that recapitulate as closely as possible what happens to patients and significantly increase the likelihood of novel therapies having clinical benefit. To achieve this we will integrate advanced surgical sampling, intracerebral microdialysis of patients and high-efficiency cell derivation techniques to generate genetically defined and clinically annotated tumour samples, cancer stem cells and xenografts. We will develop corresponding models and patient-specific cell libraries. We will use these data for high-throughput drug screening and build inter-disciplinary collaborations to exploit fully our biological, radiological and clinical data.

Delivering to patients

Correct patient selection and optimal trial design is critical for the successful clinical evaluation of new treatments. In particular, it is essential that the right patient receive the right drug and appropriate outcome measures recorded to evaluate benefits to patients in terms of survival, quality-of-life and complications. The CRUK Cambridge Centre has established a dedicated glioma clinic to provide patients with access to experts including oncologists, surgeons and specialist nurses. This multidisciplinary team can help and support patients throughout their treatment and recruit them into clinical trials wherever possible.

The in-depth understanding of brain cancer provide by the huge range of expertise in the Centre will be used to guide future management and care, and facilitate the evaluation of novel therapeutic approaches tailored to the most appropriate group of patients. In this way we will rapidly and efficiently evaluate markers of detection, diagnosis, response and progression in patients.

Programme Contacts

Cambridge University Hospitals NHS Foundation Trust
Department of Clinical Neuroscience
Programme Lead
University of Cambridge
Cancer Research UK Cambridge Institute
Programme Lead
University of Cambridge
Department of Oncology
Programme Manager

Selected publications