Mr Richard Mair
My research is focused on the interaction between the microenvironment and genome and how this comes to define brain tumours. I am using novel and
established technologies alongside samples collected from neurosurgical patients to investigate this interaction. I am interested in understanding the heterogeneity present within glioblastoma and how this can be understood through the development of novel imaging and genomics-based technologies. I work from both a basic science and a translational research perspective.
Symplectic Elements feed provided by Research Information, University of Cambridge
Measurements of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models. Mair R, Mouliere F, Chandrananda D, Smith C, Gale D, Massie C, Wright A, Brindle K, Rosenfeld N. Cancer Res. 2019;79(1):220-230
Non-invasive detection of genomic copy number alterations in primary glioma using short fragments of cell-free DNA in cerebrospinal fluid Mouliere F, Mair R (joint first author), Chandrananda D, Smith C, Gale D, Massie C, Wright A, Brindle K, Rosenfeld N. EMBO Mol Med. 2018 10(12)
Selecting Short DNA Fragments In Plasma Improves Detection of Circulaing Tumour DNA
Mouliere F, Piskorz A, Chandrananda D, Moore E, Morris J, Smith C, Goranova T, Heider K, Mair R, Supernat A, Gounaris I, Ros S, Wan J, Jiminez-Linan M, Gale D, Brindle K, Massie C, Parkinson C, Brenton, Rosenfeld N.
Sci Transl Med. 2018;10(466).
Metabolic imaging with hyperpolarized [1-13C]pyruvate detects low levels of glycolytic activity that vary with the levels of c-Myc expression in patient-derived xenograft models of glioblastoma. Mair R, Wright A, Ros S, Hu DE, Booth TC, Kreis F, Rao J, Watts C, Brindle KM.
Cancer Res. 2018;78(18):5408-5418.
[18F]-fluoroethyltyrosine-induced Cerenkov luminescence improves image-guided surgical resection of glioma.
Lewis D, Mair R (joint first author), Wright A, Allinson K, Lyons S, Booth T, Bielik R, Price S, Soloviev D, Brindle KM.
Evolutionary dynamics of residual disease in human glioblastoma.
Spiteri I, Caravagna G, Cresswell GD, Vatsiou A, Nichol D, Acar A, Ermini L, Chkhaidze K, Werner B, Mair R, Brognaro E, Verhaak RGW, Sanguinetti G, Piccirillo SGM, Watts C, Sottoriva A.
Ann Oncol. 2019;30(3):456-463
MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.
Schilling F, Ros S, Hu DE, D'Santos P, McGuire S, Mair R, Wright AJ, Mannion E, Franklin RJ, Neves AA, Brindle KM.
Nat Biotechnol. 2017 Jan;35(1):75-80
Brain Tumor Imaging.
Brindle KM, Izquierdo-García JL, Lewis DY, Mair RJ, Wright AJ. J Clin Oncol. 2017 Jul 20;35(21):2432-2438
The value of cell-free DNA for molecular pathology
Stewart CM, Kothari PD, Mouliere F, Mair R, Somnay S, Benayed R, Zehir A, Weigelt B, Dawson SJ, Arcila ME, Berger MF, Tsui DW.
J Pathol. 2018 Apr;244(5):616-627