Mr Richard Mair

University of Cambridge

University departments: 
Cancer Research UK Cambridge Institute
University institutes: 
CRUK Cambridge Institute
NHS or other affiliations: 
Addenbrooke's Hospital

Position: Assistant Professor and Honorary Consultant Neurosurgeon
Personal home page: https://www.mair-lab.com/
Email:   info@brain.cancer.cam.ac.uk

PubMed journal articles - click here

Research description: 

My research is focused on the interaction between the microenvironment and genome and how this comes to define brain tumours. I am using novel and
established technologies alongside samples collected from neurosurgical patients to investigate this interaction. I am interested in understanding the heterogeneity present within glioblastoma and how this can be understood through the development of novel imaging and genomics-based technologies. I work from both a basic science and a translational research perspective.

Research Programme or Virtual Institute: 
Brain Cancer Virtual Institute
Secondary Programme: 
Advanced Cancer Imaging
Methods and technologies: 
Cell culture
Clinical practice
DNA sequencing
Genomics
Imaging
In vivo modelling
Magnetic Resonance Imaging (MRI)
Tumour type interests: 
Brain and central nervous system
Keywords: 
glioblastoma
dynamic nuclear hyperpolarisation
circulating DNA
neurosurgery
rjm225
Recent publications:
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Key publications: 

Measurements of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models. Mair R, Mouliere F, Chandrananda D, Smith C, Gale D, Massie C, Wright A, Brindle K, Rosenfeld N. Cancer Res. 2019;79(1):220-230

Non-invasive detection of genomic copy number alterations in primary glioma using short fragments of cell-free DNA in cerebrospinal fluid Mouliere F, Mair R (joint first author), Chandrananda D, Smith C, Gale D, Massie C, Wright A, Brindle K, Rosenfeld N. EMBO Mol Med. 2018 10(12)

Selecting Short DNA Fragments In Plasma Improves Detection of Circulaing Tumour DNA
Mouliere F, Piskorz A, Chandrananda D, Moore E, Morris J, Smith C, Goranova T, Heider K, Mair R, Supernat A, Gounaris I, Ros S, Wan J, Jiminez-Linan M, Gale D, Brindle K, Massie C, Parkinson C, Brenton, Rosenfeld N.
Sci Transl Med. 2018;10(466).

Metabolic imaging with hyperpolarized [1-13C]pyruvate detects low levels of glycolytic activity that vary with the levels of c-Myc expression in patient-derived xenograft models of glioblastoma. Mair R, Wright A, Ros S, Hu DE, Booth TC, Kreis F, Rao J, Watts C, Brindle KM.
Cancer Res. 2018;78(18):5408-5418.

[18F]-fluoroethyltyrosine-induced Cerenkov luminescence improves image-guided surgical resection of glioma.
Lewis D, Mair R (joint first author), Wright A, Allinson K, Lyons S, Booth T, Bielik R, Price S, Soloviev D, Brindle KM.
Theranostics. 2018;8(14):3991-4002.

Evolutionary dynamics of residual disease in human glioblastoma.
Spiteri I, Caravagna G, Cresswell GD, Vatsiou A, Nichol D, Acar A, Ermini L, Chkhaidze K, Werner B, Mair R, Brognaro E, Verhaak RGW, Sanguinetti G, Piccirillo SGM, Watts C, Sottoriva A.
Ann Oncol. 2019;30(3):456-463

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.
Schilling F, Ros S, Hu DE, D'Santos P, McGuire S, Mair R, Wright AJ, Mannion E, Franklin RJ, Neves AA, Brindle KM.
Nat Biotechnol. 2017 Jan;35(1):75-80

Brain Tumor Imaging.
Brindle KM, Izquierdo-García JL, Lewis DY, Mair RJ, Wright AJ. J Clin Oncol. 2017 Jul 20;35(21):2432-2438

The value of cell-free DNA for molecular pathology
Stewart CM, Kothari PD, Mouliere F, Mair R, Somnay S, Benayed R, Zehir A, Weigelt B, Dawson SJ, Arcila ME, Berger MF, Tsui DW.
J Pathol. 2018 Apr;244(5):616-627