Mr Richard Mair

Position: Clinical Lecturer and Honorary Specialist Registrar in Neurosurgery
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PubMed journal articles - click here

Research description

My research is focused on the interaction between the microenvironment and genome and how this comes to define brain tumours. I am using novel and
established technologies alongside samples collected from neurosurgical patients to investigate this interaction. I am interested in understanding the heterogeneity present within glioblastoma and how this can be understood through the development of novel imaging and genomics-based technologies. I work from both a basic science and a translational research perspective.

Research Programme
Advanced Cancer Imaging
Methods and technologies
Cell culture
Clinical practice
DNA sequencing
In vivo modelling
Magnetic Resonance Imaging (MRI)
Tumour type interests
Brain and central nervous system
dynamic nuclear hyperpolarisation
circulating DNA
Recent publications:
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Key publications

Metabolic imaging with hyperpolarized [1-13C]pyruvate detects low levels of glycolytic activity that vary with the levels of c-Myc expression in patient-derived xenograft models of glioblastoma.
Mair R, Wright A, Ros S, Hu DE, Booth TC, Kreis F, Rao J, Watts C, Brindle KM.
Cancer Res. 2018;78(18):5408-5418.

[18F]-fluoroethyltyrosine-induced Cerenkov luminescence improves image-guided surgical resection of glioma.
Lewis D, Mair R (joint first author), Wright A, Allinson K, Lyons S, Booth T, Bielik R, Price S, Soloviev D, Brindle KM.
Theranostics. 2018;8(14):3991-4002.

Measurements of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models.
Mair R, Mouliere F, Chandrananda D, Smith C, Gale D, Massie C, Wright A, Rosenfeld N, Brindle K.
Cancer Res. (In press)

Non-invasive detection of genomic copy number alterations in primary glioma using short fragments of cell-free DNA in cerebrospinal fluid
Mouliere F, Mair R (joint first author), Chandrananda D, Smith C, Gale D, Massie C, Wright A, Brindle K, Rosenfeld N.
EMBO Mol Med. (In press)

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.
Schilling F, Ros S, Hu DE, D'Santos P, McGuire S, Mair R, Wright AJ, Mannion E, Franklin RJ, Neves AA, Brindle KM.
Nat Biotechnol. 2017 Jan;35(1):75-80

Selecting Short DNA Fragments In Plasma Improves Detection of Circulating Tumor DNA
Mouliere F, Piskorz A, Chandrananda D, Moore E, Morris J, Smith C, Goranova T, Heider K, Mair R, Supernat A, Gounaris I, Ros S, Wan J, Jiminez-Linan M, Gale D, Brindle K, Massie C, Parkinson C, Brenton, Rosenfeld N.
Sci Transl Med. (In press)

Brain Tumor Imaging.
Brindle KM, Izquierdo-García JL, Lewis DY, Mair RJ, Wright AJ.
J Clin Oncol. 2017 Jul 20;35(21):2432-2438

The value of cell-free DNA for molecular pathology
Stewart CM, Kothari PD, Mouliere F, Mair R, Somnay S, Benayed R, Zehir A, Weigelt B, Dawson SJ, Arcila ME, Berger MF, Tsui DW.
J Pathol. 2018 Apr;244(5):616-627