Clinical research on radiotherapy treatment

Radiotherapy is a treatment where radiation is used to kill cancer cells. It can be used to either cure the cancer (radical treatment) or to help relieve symptoms when a cure is not possible (palliative treatment). Radiotherapy is considered the most effective cancer treatment after surgery.

Research is continuing to try to improve radiotherapy treatments and reduce side effects.

Radiotherapy trials

Radiotherapy trials can be used to:

  • Identify the optimum treatment dose that gives greatest tumour control and minimal side effects
  • Explore new techniques and technologies
  • Explore its role when combined with other treatments such as chemotherapy and surgery.

The CCTC works closely with the Addenbrooke’s radiotherapy department. Addenbrooke’s houses one of the top-rated radiotherapy services in the UK. The department sees over 200 patients a day and is a specialist referral centre for many of the rarer cancers. This means that, as well as local patients, they see patients from across the region and the UK.

Current open trials in Cambridge

The radiotherapy trials team cross-cover many different treatment sites. If you are a patient and want to know more about radiotherapy trials relevant to you, please click on the relevant treatment site.

Staff

Cambridge University Hospitals NHS Foundation Trust
Department of Oncology
University of Cambridge, Cambridge University Hospitals NHS Foundation Trust
Department of Oncology
Cambridge University Hospitals NHS Foundation Trust
Department of Oncology
Cambridge University Hospitals NHS Foundation Trust
Department of Oncology
Titlesort descending Trial description Contact name Trial end date Trial start date Trial tumour type
ABC-07 Addition of stereotactic radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers Dr Thankamma Ajithkumar 31 Aug 2023 5 Apr 2017 Liver & Bile Duct
ADSCaN A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-small Cell Lung Cancer Dr David Gilligan 31 Dec 2021 23 Nov 2017 Lung
Best-Of Phase III study assessing the "Best-Of" radiotherapy compared to the "Best-Of" surgery (trans-oral surgery (TOS) in patients with T1-T2, N0 oropharyngeal carcinoma Dr Ekpemi Irune 1 Jan 2026 17 Nov 2020 Head & neck
CompARE Trial Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer Dr Rashmi Jadon 31 Jan 2026 5 Mar 2019 Head & neck
EMBRACE-II Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer Dr Li Tee Tan 30 Jun 2024 7 Nov 2017 Gynaecological
Hamlet.rt (H&N) Hamlet.rt - Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy Dr Raj Jena 31 Oct 2021 24 Oct 2019 Head & neck
Hamlet.rt (Prostate) Hamlet.rt - Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy Dr Raj Jena 31 Oct 2021 24 Oct 2019 Prostate
PACE-C International randomised study of prostatectomy vs stereotactic body radiotherapy (SBRT) and conventional radiotherapy vs SBRT for organ-confined prostate cancer Dr Alex Martin 26 Apr 2026 5 Feb 2020 Prostate
PATHOS A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer Dr Ekpemi Irune 31 Dec 2021 16 Jun 2017 Head & neck
PIVOTALboost A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost. Dr Yvonne Rimmer 17 Aug 2021 7 Mar 2018 Prostate
PLATO PersonaLising Anal cancer radioTherapy dOse Dr Catherine Jephcott 31 Dec 2022 22 Mar 2017 Colorectal
POPS A randomised phase II trial assessing Post-Operative use of ProSpare, a rectal obturator in prostate cancer radiotherapy Dr Yvonne Rimmer 31 Dec 2021 4 Jul 2017 Prostate
PORTICO SABR Pre-operative stereotactic ablative body radiotherapy followed by immediate surgery in pancreatic adenocarcinoma: A window of opportunity feasibility study Dr Thankamma Ajithkumar 16 Jun 2021 26 Oct 2020 Pancreatic
PRIMETIME Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers Dr Charlotte Coles 31 Dec 2021 18 May 2017 Breast
Quality of Life After Bladder Cancer (Q-ABC) A comparison of patient related outcomes following radical surgery and radiotherapy Dr Yvonne Rimmer 1 Mar 2022 23 Oct 2018 Bladder
ROAM Radiation versus observation following surgical resection of atypical meningioma: A randomised controlled trial Dr Sarah Jefferies 30 Apr 2025 17 Nov 2016 Brain and CNS
SARON Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial Dr Alex Martin 4 Jul 2023 9 Aug 2017 Lung