Clinical research on radiotherapy treatment

Radiotherapy is a treatment where radiation is used to kill cancer cells. It can be used to either cure the cancer (radical treatment) or to help relieve symptoms when a cure is not possible (palliative treatment). Radiotherapy is considered the most effective cancer treatment after surgery.

Research is continuing to try to improve radiotherapy treatments and reduce side effects.


Cambridge University Hospitals NHS Foundation Trust
Department of Oncology
Cambridge University Hospitals NHS Foundation Trust
Department of Oncology
Cambridge University Hospitals NHS Foundation Trust
Department of Oncology
Cambridge University Hospitals NHS Foundation Trust
Department of Oncology
Radiotherapy trials

Radiotherapy trials can be used to:

  • Identify the optimum treatment dose that gives greatest tumour control and minimal side effects
  • Explore new techniques and technologies
  • Explore its role when combined with other treatments such as chemotherapy and surgery.

The CCTC works closely with the Addenbrooke’s radiotherapy department. Addenbrooke’s houses one of the top-rated radiotherapy services in the UK. The department sees over 200 patients a day and is a specialist referral centre for many of the rarer cancers. This means that, as well as local patients, they see patients from across the region and the UK.

Current open trials in Cambridge

The radiotherapy trials team cross-cover many different treatment sites. If you are a patient and want to know more about radiotherapy trials relevant to you, please click on the relevant treatment site.

Titlesort descending Trial description Contact name Trial end date Trial start date Trial tumour type
ABC-07 Addition of stereotactic radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers Dr Thankamma Ajithkumar 31 Aug 2023 5 Apr 2017 Liver & Bile Duct
ADSCaN A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-small Cell Lung Cancer Dr Susan Harden 31 Dec 2021 23 Nov 2017 Lung
CORE A randomised trial of conventional care versus radioablation (stereotactic body radiotherapy) for extracranial metastases Dr Susan Harden 2 Sep 2020 29 Mar 2018 Lung, Breast, Prostate
EMBRACE-II Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer Dr Li Tee Tan 30 Jun 2024 7 Nov 2017 Gynaecological
FAST-Forward FAST Forward is a randomised clinical trial testing a 1-week course of curative whole breast radiotherapy against a standard 3-week schedule in terms of local cancer control and late adverse effects in patients with early breast cancer. The lymphatic RT sub-study an extension to the FAST-Forward trial, which maintains its original design but whose entry is now restricted to patients prescribed radiotherapy to level I-III axilla and/or level IV axilla (supraclavicular fossa (SCF)) in addition to the breast/chest wall area. Dr Charlotte Coles 1 Feb 2022 12 Mar 2012 Breast
Neo-AEGIS Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction Dr Hugo Ford 1 Sep 2020 24 Nov 2015 Oesophageal
PATHOS A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer Dr Ekpemi Irune 28 Feb 2019 16 Jun 2017 Head & neck
PIVOTALboost A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost. Dr Yvonne Rimmer 17 Aug 2020 7 Mar 2018 Prostate
PLATO PersonaLising Anal cancer radioTherapy dOse Dr Catherine Jephcott 31 Dec 2022 22 Mar 2017 Colorectal
POPS A randomised phase II trial assessing Post-Operative use of ProSpare, a rectal obturator in prostate cancer radiotherapy Dr Yvonne Rimmer 31 Dec 2019 4 Jul 2017 Prostate
PRIMETIME Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers Dr Charlotte Coles 31 Dec 2021 18 May 2017 Breast
Quality of Life After Bladder Cancer (Q-ABC) A comparison of patient related outcomes following radical surgery and radiotherapy Dr Yvonne Rimmer 1 Mar 2022 23 Oct 2018 Bladder
Quartus Quantification of breast radiotheraphy associated in late toxicity using novel ultrasound techniques Dr Charlotte Coles 31 Jan 2019 13 May 2016 Breast
RAIDER A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder Dr Yvonne Rimmer 21 Mar 2029 6 Jan 2016 Bladder
Rational MCC Rational treatment selection for Merkel Cell Carcinoma (MCC): A randomised phase III multi-centre trial comparing radical surgery and radical radiotherapy as first definitive treatment for primary MCC with an observational study for patients ineligible for the randomised trial. Dr Kate Fife 31 Dec 2022 22 Dec 2016 Skin & melanoma
SARON Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial Dr Susan Harden 4 Jul 2023 9 Aug 2017 Lung
SCALOP-2 A multi-centre randomised study of induction chemotherapy followed by capecitabine (+/-nelfinavir) with high or standard dose radiotherapy for locally advanced non-metastatic pancreatic cancer Dr Thankamma Ajithkumar 21 Mar 2019 18 Aug 2016 Pancreatic