Clinical research on radiotherapy treatment

Radiotherapy is a treatment where radiation is used to kill cancer cells. It can be used to either cure the cancer (radical treatment) or to help relieve symptoms when a cure is not possible (palliative treatment). Radiotherapy is considered the most effective cancer treatment after surgery.

Research is continuing to try to improve radiotherapy treatments and reduce side effects.

Staff

Cambridge University Hospitals NHS Foundation Trust
Radiotherapy trials

Radiotherapy trials can be used to:

  • Identify the optimum treatment dose that gives greatest tumour control and minimal side effects
  • Explore new techniques and technologies
  • Explore its role when combined with other treatments such as chemotherapy and surgery.

The CCTC works closely with the Addenbrooke’s radiotherapy department. Addenbrooke’s houses one of the top-rated radiotherapy services in the UK. The department sees over 200 patients a day and is a specialist referral centre for many of the rarer cancers. This means that, as well as local patients, they see patients from across the region and the UK.

Current open trials in Cambridge

The radiotherapy trials team cross-cover many different treatment sites. If you are a patient and want to know more about radiotherapy trials relevant to you, please click on the relevant treatment site.

Titlesort descending Trial description Contact name Trial end date Trial start date Trial tumour type
ABC-07 Addition of stereotactic radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers Dr Thankamma Ajithkumar 31 Aug 2023 5 Apr 2017 Liver & Bile Duct
ADSCaN A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-small Cell Lung Cancer Dr Susan Harden 31 Dec 2021 23 Nov 2017 Lung
EMBRACE-II Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer Dr Li Tee Tan 30 Jun 2024 7 Nov 2017 Gynaecological
ENZARAD Randomised phase 3 trial of enzalutamide in androgen deprivation therapy with radiation therapy for high risk, clinically localised, prostate cancer Dr Yvonne Rimmer 1 Jan 2028 17 Apr 2016 Prostate
FAST-Forward FAST Forward is a randomised clinical trial testing a 1-week course of curative whole breast radiotherapy against a standard 3-week schedule in terms of local cancer control and late adverse effects in patients with early breast cancer. The lymphatic RT sub-study an extension to the FAST-Forward trial, which maintains its original design but whose entry is now restricted to patients prescribed radiotherapy to level I-III axilla and/or level IV axilla (supraclavicular fossa (SCF)) in addition to the breast/chest wall area. Dr Charlotte Coles 1 Feb 2022 12 Mar 2012 Breast
Neo-AEGIS Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction Dr Hugo Ford 1 Sep 2020 24 Nov 2015 Oesophageal
Neo-RT Pre-operative breast intensity modulated radiotherapy in patients receiving neo-adjuvant hormonal treatment for breast cancer – a feasibility study Dr Charlotte Coles 1 Sep 2024 4 Dec 2017 Breast
NIMRAD A randomised placebo-controlled trial of synchronous NIMorazole versus RADiotherapy alone in patients with locally advanced head and neck squamous cell carcinoma not suitable for synchronous chemotherapy or cetuximab Dr Gill Barnett 6 Nov 2018 24 Oct 2014 Head & neck
PARADIGM OlaPArib And RADiotherapy In newly-diagnosed GlioblastoMa: Short-course radiotherapy plus olaparib for newly diagnosed glioblastoma in patients unsuitable for radical chemoradiation: a randomised phase II clinical trial preceded by a lead-in phase I dose escalation study Dr Sarah Jefferies 31 Dec 2018 4 Nov 2016 Brain and CNS
PATHOS A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer Dr Ekpemi Irune 28 Feb 2019 16 Jun 2017 Head & neck
PIVOTALboost A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost. Dr Yvonne Rimmer 31 Dec 2021 7 Mar 2018 Prostate
PLATO PersonaLising Anal cancer radioTherapy dOse Dr Catherine Jephcott 31 Dec 2022 22 Mar 2017 Colorectal
POPS A randomised phase II trial assessing Post-Operative use of ProSpare, a rectal obturator in prostate cancer radiotherapy Dr Yvonne Rimmer 31 Dec 2019 4 Jul 2017 Prostate
POSNOC POsitive Sentinel NOde: adjuvant therapy alone versus adjuvant therapy plus Clearance or axillary radiotherapy. A randomised controlled trial of axillary treatment in women with early stage breast cancer who have metastases in one or two sentinel nodes Professor John Benson 30 Sep 2018 8 Aug 2014 Breast
PRIMETIME Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers Dr Charlotte Coles 31 Dec 2021 18 May 2017 Breast
Quartus Quantification of breast radiotheraphy associated in late toxicity using novel ultrasound techniques Dr Charlotte Coles 31 Jan 2019 13 May 2016 Breast
RAIDER A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder Dr Yvonne Rimmer 21 Mar 2029 6 Jan 2016 Bladder
RAPPER Radiogenomics: assessment of polymorphisms for predicting the effects of radiotherapy Dr Gill Barnett 31 Jul 2018 11 Jan 2006 Bladder, Brain and CNS, Head & neck, Prostate, Sarcoma
Rational MCC Rational treatment selection for Merkel Cell Carcinoma (MCC): A randomised phase III multi-centre trial comparing radical surgery and radical radiotherapy as first definitive treatment for primary MCC with an observational study for patients ineligible for the randomised trial. Dr Kate Fife 31 Dec 2022 22 Dec 2016 Skin & melanoma
ROAM Radiation versus observation following surgical resection of atypical meningioma: A randomised controlled trial Dr Sarah Jefferies 30 Apr 2025 17 Nov 2016 Brain and CNS
SARON Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial Dr Susan Harden 4 Jul 2023 9 Aug 2017 Lung
SCALOP-2 A multi-centre randomised study of induction chemotherapy followed by capecitabine (+/-nelfinavir) with high or standard dose radiotherapy for locally advanced non-metastatic pancreatic cancer Dr Thankamma Ajithkumar 21 Mar 2019 18 Aug 2016 Pancreatic
SCOPE-2 A randomised Phase II/III trial to study radiotherapy dose escalation in patients with oesophageal cancer treated with definitive chemoradiation with an embedded Phase II trial for patients with a poor early response using positron emission tomography (PET). Dr Susan Harden 31 Dec 2025 28 Feb 2018 Oesophageal
VoxTox - CNS An observational study to collect comprehensive toxicity data for patients undergoing image-guided intensity-modulated radiotherapy to the head and neck, prostate, and central nervous system Dr Raj Jenna 9 Jan 2023 27 Feb 2013 Brain and CNS
VoxTox Head and Neck An observational study to collect comprehensive toxicity data for patients undergoing image-guided intensity-modulated radiotherapy to the head and neck, prostate, and central nervous system Dr Raj Jena 9 Jan 2023 27 Feb 2013 Head & neck