Professor Charlotte Coles

Cambridge University Hospitals NHS Foundation Trust

University departments
Department of Oncology
NHS or other affiliations
Addenbrooke's oncology centre

Position: Clinical Consultant, NIHR Research Professor, Reader in Breast Radiation Oncology, Deputy Head of Dept of Oncology, CRUK RadNet Cambridge lead
Personal home page:

PubMed journal articles - click here

Professor Charlotte Coles is pleased to consider applications from prospective PhD students.

Research description

Prof Charlotte Coles is a National Institute of Health Research (NIHR) Research Professor and Reader in Breast Radiation Oncology at the Cancer Research UK Cambridge Centre.

Her research aims are to provide breast cancer patients with the best chance of cure with least side effects by personalising radiation techniques based on risk of recurrence.

She is Chief Investigator of 4 clinical trials with linked translational research:
1. IMPORT LOW: phase III randomised trial (RCT) investigating intensity modulated radiotherapy (IMRT) and partial breast radiotherapy in patients at low risk of recurrence – in follow up: 2018 patients recruited; 71 UK centres
2. IMPORT HIGH: phase III RCT investigating dose-escalated IMRT for patients at higher risk of recurrence - in follow up: 2617 patients recruited; 77 UK centres
3. PRIMETIME: prospective cohort investigating post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers – open: 45 UK centres to date
4. NEO-RT: feasibility study investigating pre-operative breast IMRT in patients receiving neo-adjuvant hormonal treatment – open: 2 UK centres

Prof Coles is also Chair of the UK National Cancer Research Institute Breast Clinical Studies Early Disease Subgroup, Editor-in-Chief of Clinical Oncology journal and lead for Cancer Research UK RadNet Cambridge Radiation Research Centre of Excellence.

Research Programme
Breast Cancer
Keywords

radiotherapy

cec50
Recent publications:
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Key publications

1. Bhattacharya IS, Haviland JS, Kirby AM, Kirwan CC, Hopwood P, Yarnold JR, Bliss JM and Coles CE on behalf of the IMPORT Trialists.  Patient reported outcomes over 5 years following whole or partial breast radiotherapy: longitudinal analysis of the IMPORT LOW phase III randomised controlled trial.  J Clin Oncol. 2019 Feb 1;37(4):305-317. doi: 10.1200/JCO.18.00982. Epub 2018 Dec 11.

2. Coles CE, Griffin CL, Kirby AM, Titley J, Agrawal RK, Alhasso A, Bhattacharya IS, Brunt AM, Ciurlionis L, Chan C, Donovan EM, Emson MA, Harnett AN, Haviland JS, Hopwood P, Jefford ML, Kaggwa R, Sawyer EJ, Syndikus I, Tsang YM, Wheatley DA, Wilcox M, Yarnold JR, Bliss JM; IMPORT Trialists. Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial. Lancet. 2017 Sep 9;390(10099):1048-1060.

3. MukeshMB, BarnettGC, WilkinsonJS, MoodyAM, WilsonCB, DorlingL, Chan Wah Hak C, QianW, TwymanN, BurnetNG, WishartGC and ColesCE. A randomised controlled trial of Intensity Modulated Radiotherapy (IMRT) for early breast cancer: 5-year results confirm superior overall cosmesis. J Clin Oncol. 2013. 31; 36: 4488-95