Clinical Trials

These are the trials that are currently open in the Early Phase trials team (Last updated 16 May 2019).

Trial Short Name Molecular Target(s)   Patient Population Lead Investigator(s)
in Cambridge
 
AZD1390 ATM with RT Glioblastoma  S Jeffries / R Baird 
AZD9833 ORAL SERD ERα ER positive, HER2 negative advanced breast cancer   R Baird
Basket of Baskets PD-L1 Solid tumours with high mutational load/MSI  R Baird
CALIBRATE cfDNA evaluation Patients on early phase clinical trials R Baird / S Pacey
CALIBRATION ctDNA evaluation Advanced oesophageal malignancies S Pacey
 CamBMT1 phase II  EGFR/HER2 Operable brain metastasis (breast/lung)   R Baird
CT7001 CDK7 Metastatic or locally advanced triple-negative breast cancer R Baird
GO40782  NTRK1/2/3 Proven NTRK1/2/3 gene rearrangements   S Pacey
iBET Bromodomain  Haematologic malignancies  B Huntly 
LEAP-005 PD-1 & RTK Advanced TNBC, ovarian cancer, gastric cancer, colorectal cancer, GBM or BTC B Basu 
ONX-0801 α-folate receptor   Platinum resistant ovarian cancer  B Basu
OUTREACH CEBPα Hepatocellular carcinoma   B Basu
PARADIGM 2 PARP Glioblastoma stratified by MGMT status   S Jeffries / R Baird
PATRIOT ATR Any tumour type – palliative radiotherapy combined with ATR inhibitor  R Baird 
POSEIDON phase II PI3K HR+ metastatic breast cancer R Baird