Clinical Trials

These are the trials that are currently open in the Early Phase Unit (Last updated 13 September 2018).

Trial Short Name Molecular Target(s)   Patient Population Lead Investigator(s)
in Cambridge
AZD1390 ATM with RT Glioblastoma S Jeffries / R Baird
 AZD6738 combo
with olaparib
 ATR/PARP  Gastric cancer (low ATM expression) & BRCA
mutation/HRD high breast cancer
 D Jodrell
AZD8186 PIK3CB Prostate, TNBC, NSCLC, with pre-screening for PTEN deficiency R Baird
CALIBRATE cfDNA evaluation Patients on early phase clinical trials R Baird / S Pacey
 CamBMT1 phase II  EGFR/HER2 Operable brain metastasis (breast/lung)   R Baird
 CAM-PLEX   CXCR4  Metastatic pancreatic cancer with biopsiable disease    D Jodrell / B Basu 
CURIS PD-1/PD-L1/VISTA Any tumour site with FDA approved immunotherapy option S Pacey
G1T38 CDK4/6 ER-positive breast cancer, CDK4/6 inhibitor plus fulvestrant R Baird
 iBET Bromodomain  Haematologic malignancies  B Huntly 
 ONX-0801  α-folate receptor  Platinum resistant ovarian cancer B Basu 
 CEBPα Hepatocellular carcinoma  B Basu 
PARADIGM 2 PARP Glioblastoma stratified by MGMT status S Jeffries / R Baird
POSEIDON phase II PI3K HR+ metastatic breast cancer R Baird
 STARTRK2  NTRK1/2/3/ROS1/ALK Proven NTRK1/2/3, ROS1 or ALK gene rearrangements   S Pacey
VAPER hTERT Advanced solid tumours R Baird