Clinical Trials

These are the trials that are currently open in the Early Phase trials team (Last updated 21 March 2019).

Trial Short Name Molecular Target(s)   Patient Population Lead Investigator(s)
in Cambridge
 AZD6738 combo
with olaparib
 ATR/PARP  Gastric cancer (low ATM expression) & BRCA
mutation/HRD high breast cancer
 D Jodrell
Basket of Baskets PD-L1 Solid tumours with high mutational load/MSI  R Baird
CALIBRATE cfDNA evaluation Patients on early phase clinical trials R Baird / S Pacey
CALIBRATION ctDNA evaluation Advanced oesophageal malignancies S Pacey
 CamBMT1 phase II  EGFR/HER2 Operable brain metastasis (breast/lung)   R Baird
GO40782  NTRK1/2/3 Proven NTRK1/2/3 gene rearrangements   S Pacey
iBET Bromodomain  Haematologic malignancies  B Huntly 
MOv18 IgE IgE antibody/ α-FR α-Folate receptor over-expressing gynaecological tumours   B Basu
ONX-0801 α-folate receptor Platinum resistant ovarian cancer   B Basu
OUTREACH CEBPα Hepatocellular carcinoma   B Basu
PATRIOT ATR Any tumour type – palliative radiotherapy combined with ATR inhibitor  R Baird 
POSEIDON phase II PI3K HR+ metastatic breast cancer R Baird