The Early Phase Trials team have decided to suspend recruitment of patients as a result of the evolving situation with COVID-19. We feel that this is appropriate and takes into consideration multiple factors such as the risk to patients associated with increased travelling, additional hospital visits to Addenbrooke's and concerns about the uncertainty of possible side effects associated with experimental therapy (such as myelo- and immuno-suppression or pneumonitis).
(Last updated 28/07/2021)
| Trial Short Name | Molecular Target(s) | Patient Population | Lead Investigator(s) in Cambridge |
| AZD1390 | ATM with RT | Glioblastoma | G Doherty |
| Basket of Baskets | PD-L1 FGFR | Solid tumours with high mutational load/MSI+/- FGFR mutations | R Baird |
| CALIBRATION | PD-L1 | Advanced oesophageal malignancies | S Pacey |
| GO40782 | NTRK1/2/3 | Solid tumour, NTRK1/2/3 gene rearrangements | S Pacey |
| LEAP-005 | PD-1 & RTK | 2L/3L TNBC, 4L ovarian cancer, 2L gastric cancer, 2L GBM or 2L BTC, 2L/3L pancreatic cancer | B Basu |
| PATRIOT | ATR | Any tumour type – palliative radiotherapy combined with ATR inhibitor | R Baird |
| MOv18 igE | α-folate receptor | Gyane aFR+ | B Basu |
| Atrium | ATR | Solid tumours | D Jodrell |
| AZD9833 | ER | ER+ HER2- advanced breast cancer | R Baird |
| PARADIGM-2 | PARP | Glioblastoma | S Jefferies |
| AZD6738 | ATR inhibitor | Ovarian cancer expansion (Post PARPi, BRCAm, platinum sensitive) all comers | D Jodrell/ B Basu |
| BT1718 | MT1-MMP | NSCLC, solid tumours with high MT1-MMP expression | B Basu |
| Incyte 86550-102 | Multiple | PDL1-inhibitor naïve tumours that may respond to immune checkpoint inhibitors, HPV+ tumours, MSI/TMB hi, PD-L1–amplified tumour | B Basu |
| CCS1477 | P300/CBP |
mCRPC or solid tumours with actionable target related to p300/CBP inhibition [ARID1A/P300/CBP mt; small cell cancer |
S Pacey |
| MCLA-158 | LGR5/EGFR | Squamous cell head and neck cancer | E Smyth/ D Jodrell |
| Timepoint- MTLCEBPα | PD1 and CEBP | Advanced lung, ovary, pancreatic, gallbladder, neuroendocrine, breast | B Basu |
