The Early Phase Trials team have decided to suspend recruitment of patients as a result of the evolving situation with COVID-19. We feel that this is appropriate and takes into consideration multiple factors such as the risk to patients associated with increased travelling, additional hospital visits to Addenbrooke's and concerns about the uncertainty of possible side effects associated with experimental therapy (such as myelo- and immuno-suppression or pneumonitis).
At this time, we are only able to offer an outpatient consultation, preferably “remotely” so that we avoid additional hospital visits, during which time we can start to discuss what taking part in trials might involve.
These decisions will remain under regular review and will be updated as new information becomes available. (Last updated 24/04/2020)
| Trial Short Name | Molecular Target(s) | Patient Population | Lead Investigator(s) in Cambridge |
| AZD1390 | ATM with RT | Glioblastoma | S Jeffries / G Doherty |
| Basket of Baskets | PD-L1 | Solid tumours with high mutational load/MSI | R Baird |
| CALIBRATION | ctDNA evaluation | Advanced oesophageal malignancies | S Pacey |
| CamBMT1 phase II | EGFR/HER2 | Operable brain metastasis (breast/lung) | R Baird |
| CT7001 | CDK7 | Metastatic or locally advanced triple-negative breast cancer | R Baird |
| GO40782 | NTRK1/2/3 | Proven NTRK1/2/3 gene rearrangements | S Pacey |
| LEAP-005 | PD-1 & RTK | Advanced TNBC, ovarian cancer, gastric cancer, GBM or BTC | B Basu |
| OUTREACH | CEBPα | Hepatocellular carcinoma | B Basu |
| PATRIOT | ATR | Any tumour type – palliative radiotherapy combined with ATR inhibitor | R Baird |
| POSEIDON phase II | PI3K | HR+ metastatic breast cancer | R Baird |
| MOv18 igE | α-folate receptor | Gyane aFR+ | B Basu |
| BOSTON | Mps1 | Advanced nonhaematological malignancies | B Basu |
| MP0274 | HER2 | HER2+ solid tumours | R Baird |
| Atrium | ATR | Solid tumours | D Jodrell |
| AZD9833 | ER | ER+ HER2- advanced breast cancer | R Baird |
| PARADIGM-2 | PARP | Glioblastoma | S Jefferies/ R Baird |
