Clinical Trials

These are the trials that are currently open in the Early Phase trials team (Last updated 15 August 2019).

Trial Short Name Molecular Target(s)   Patient Population Lead Investigator(s)
in Cambridge
AZD1390 ATM with RT Glioblastoma  S Jeffries / R Baird 
Basket of Baskets PD-L1 Solid tumours with high mutational load/MSI  R Baird
CALIBRATE cfDNA evaluation Patients on early phase clinical trials R Baird / S Pacey
CALIBRATION ctDNA evaluation Advanced oesophageal malignancies S Pacey
 CamBMT1 phase II  EGFR/HER2 Operable brain metastasis (breast/lung)   R Baird
CT7001 CDK7 Metastatic or locally advanced triple-negative breast cancer R Baird
GO40782  NTRK1/2/3 Proven NTRK1/2/3 gene rearrangements   S Pacey
iBET Bromodomain  Haematologic malignancies  B Huntly 
LEAP-005 PD-1 & RTK Advanced TNBC, ovarian cancer, gastric cancer, GBM or BTC B Basu 
ONX-0801 α-folate receptor   Platinum resistant ovarian cancer  B Basu
OUTREACH CEBPα Hepatocellular carcinoma   B Basu
PATRIOT ATR Any tumour type – palliative radiotherapy combined with ATR inhibitor  R Baird 
POSEIDON phase II PI3K HR+ metastatic breast cancer R Baird
MOv18 igE α-folate receptor  Gyane aFR+ B Basu
BOSTON Mps1 Advanced nonhaematological malignancies B Basu 
MP0274 HER2 HER2+ solid tumours R Baird
AZD6738 ATR Solid tumours D Jodrell
AZD9833 HER2 ER+ HER2- advanced breast cancer R Baird
PARADIGM-2 PARP Glioblastoma  S Jefferies/ R Baird