Clinical Trials

These are the trials that are currently open in the Early Phase Unit (Last updated 01 November 2018).

Trial Short Name Molecular Target(s)   Patient Population Lead Investigator(s)
in Cambridge
 AZD6738 combo
with olaparib
 ATR/PARP  Gastric cancer (low ATM expression) & BRCA
mutation/HRD high breast cancer
 D Jodrell
BOS172722 Monopolar spindle 1 kinase inhibitor Solid tumours suitable for weekly taxol B Basu
CALIBRATE cfDNA evaluation Patients on early phase clinical trials R Baird / S Pacey
CALIBRATION ctDNA evaluation Advanced oesophageal malignancies S Pacey
 CamBMT1 phase II  EGFR/HER2 Operable brain metastasis (breast/lung)   R Baird
 CAM-PLEX   CXCR4  Metastatic pancreatic cancer with biopsiable disease    D Jodrell / B Basu 
G1T38 CDK4/6 ER-positive breast cancer, CDK4/6 inhibitor plus fulvestrant R Baird
 iBET Bromodomain  Haematologic malignancies  B Huntly 
POSEIDON phase II PI3K HR+ metastatic breast cancer R Baird
 STARTRK2  NTRK1/2/3/ROS1/ALK Proven NTRK1/2/3, ROS1 or ALK gene rearrangements   S Pacey
VAPER hTERT Advanced solid tumours R Baird