Dr Oscar M Rueda

University of Cambridge

University departments
Cancer Research UK Cambridge Institute
University institutes
CRUK Cambridge Institute

Position: Senior Research Associate
Personal home page:

PubMed journal articles - click here

Research description

Development of statistical methods and models for the analysis and integration of breast cancer high-throughput data: detection of alterations in DNA copy number and their influence in mRNA expression and survival, in order to obtain predictive markers. Methods for classification of tumor profiles.

Research Programme
Breast Cancer
Methods and technologies
Bioinformatics
Computational modelling
DNA sequencing
Gene expression profiling
Genomics
In vivo modelling
Statistical analysis
Tumour type interests
Breast
or249
Recent publications:
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Key publications

Bruna A, Rueda OM, Greenwood W, Batra AS, Callari M, Batra RN, Pogrebniak K, Sandoval J, Cassidy JW, Tufegdzic-Vidakovic A, Sammut SJ, Jones L, Provenzano E, Baird R, Eirew P, Hadfield J, Eldridge M, McLaren-Douglas A, Barthorpe A, Lightfoot H, O'Connor MJ, Gray J, Cortes J, Baselga J, Marangoni E, Welm AL, Aparicio S, Serra V, Garnett MJ, Caldas C.
A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.
Cell. 2016 Sep 22;167(1):260-274.e22. doi: 10.1016/j.cell.2016.08.041.

Genome-driven integrated classification of breast cancer validated in over 7,500 samples.
Ali HR, Rueda OM, Chin SF, Curtis C, Dunning MJ, Aparicio SA, Caldas C.
Genome Biol. 2014 Aug 28;15(8):431. doi: 10.1186/s13059-014-0431-1.

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Gräf S, Ha G, Haffari G, Bashashati A, Russell R, McKinney S; METABRIC Group., Langerød A, Green A, Provenzano E, Wishart G, Pinder S, Watson P, Markowetz F, Murphy L, Ellis I, Purushotham A, Børresen-Dale AL, Brenton JD, Tavaré S, Caldas C, Aparicio S.
Nature. 2012 Apr 18;486(7403):346-52. doi: 10.1038/nature10983.