Dr Oscar M Rueda

University of Cambridge

University departments
MRC Biostats Unit

Position: Group Leader
Personal home page:
Email:   Oscar.Rueda@mrc-bsu.cam.ac.uk

PubMed journal articles - click here

Dr Oscar M Rueda is pleased to consider applications from prospective PhD students.

Research description

Development of statistical methods and models for the analysis and integration of breast cancer high-throughput data: detection of alterations in DNA copy number and their influence in mRNA expression and survival, in order to obtain predictive markers. Methods for classification of tumor profiles.

Research Programme
Breast Cancer
Methods and technologies
Bioinformatics
Computational modelling
DNA sequencing
Gene expression profiling
Genomics
In vivo modelling
Statistical analysis
Tumour type interests
Breast
or249
Recent publications:
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Key publications

Rueda OM, Sammut S-J, Seoane JA, Chin S-F, Caswell-Jin JL, Callari M, Batra R, Pereira B, Bruna A, Ali HR, Provenzano E, Liu B,Parisien M, Gillett C, McKinney S, Green AR, Murphy L, Purushotham A, Ellis IO, Pharoah PD, Rueda C, Aparicio S , Caldas C, and Curtis C. Dynamics of breast cancer relapse reveal molecularly defined late recurring ER-positive subgroups. Nature. 2019, 567(7748):399-404.

Bruna A, Rueda OM, Greenwood W, Batra AS, Callari M, Batra RN, Pogrebniak K, Sandoval J, Cassidy JW, Tufegdzic-Vidakovic A, Sammut SJ, Jones L, Provenzano E, Baird R, Eirew P, Hadfield J, Eldridge M, McLaren-Douglas A, Barthorpe A, Lightfoot H, O'Connor MJ, Gray J, Cortes J, Baselga J, Marangoni E, Welm AL, Aparicio S, Serra V, Garnett MJ, Caldas C.
A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.
Cell. 2016 Sep 22;167(1):260-274.e22. doi: 10.1016/j.cell.2016.08.041.

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Gräf S, Ha G, Haffari G, Bashashati A, Russell R, McKinney S; METABRIC Group., Langerød A, Green A, Provenzano E, Wishart G, Pinder S, Watson P, Markowetz F, Murphy L, Ellis I, Purushotham A, Børresen-Dale AL, Brenton JD, Tavaré S, Caldas C, Aparicio S.
Nature. 2012 Apr 18;486(7403):346-52. doi: 10.1038/nature10983.