MRes rotation projects for 2024

These following 15- week rotation projects are offered for 2024-2025. The expectation is that one of your two rotation projects will be turn into your PhD project. Each link will take you to a full project description. Please note that the Cell and Molecular Biology (CMB) programme has been relaunched under a new name: the Fundamental Biology of Cancer (FBC) programme. Only projects listed as CMB belong to the FBC programme.

 MRes Rotation Projects- CRUK Cambridge Centre 2024 

(Principal Supervisor, Department for student registration)

ASCL1 and its interactors in neuroblastoma differentiation. Prof Anna Philpott Cambridge Stem Cell Institute
Characterisation of two newly discovered ASXL-related proteins: effects on chromatin structure. Prof. Andrew Firth Dept of Pathology
Characterization of primate-specific systems regulating aspects of the DNA damage response. Dr Michael Imbeault Dept of Genetics
Combinatorial targeting of anaplastic lymphoma kinase (ALK) signalling to treat cancer and obesity Dr Florian Merkle Dept of Clinical Biochemistry (Institute of Metabolic Science)
Determining the role and potential therapeutic targeting of aberrant fatty acid metabolism in lymphoma. Prof Brian Huntly Cambridge Stem Cell Institute (Haematology) 
Development and testing of next generation oncolytic vaccinia viruses.  Dr Brian Ferguson Dept of Pathology
Do small cell lung cancers exploit developmental mechanisms? * Dr Emma Rawlins Dept of Physiology, Development and Neuroscience
Elucidating the role of Micropeptides in B cell lymphoma. * Dr Dan Hodson Cambridge Stem Cell Institute (Haematology) 
Engineering AI to map broken and repaired DNA during genome replication.  Dr Michael Boemo  Dept of Pathology 
Exploring VHL-independent regulatory mechanism(s) of HIF for therapeutic benefit.  Prof Margaret Ashcroft  Dept of Medicine
Genetic interrogation of histone lysine demethylation by UTX.  * Dr Iva Tchasovnikarova  Dept of Biochemistry 
Hamlet.rt Collect: Use of 3D epithelioid models to improve survival from head and neck cancer.  * Dr Gillian C Barnett Dept. of Oncology 
How do Leukaemia Mutations Alter Tissue Dynamics of Blood Stem / Progenitor Cells? Prof Bertie Gottgens  Cambridge Stem Cell Institute (Haematology) 
Human ultra-high field (7T) deuterium metabolic imaging. * Prof Chris Rodgers  Dept of Clinical Neurosciences (Wolfson Brain Imaging Centre)
Investigating the role of cell migration in the pathogenesis of extragonadal germ cell tumours.  Prof Ewa Paluch Dept of Physiology, Development and Neuroscience
Investigating the role of immune cell-mediated steroidogenesis in regulating cancer inflammation and immunity.  Dr Bidesh Mahata Dept of Pathology 
Machine learning and integrative ‘omics for multi-cancer risk prediction.   Dr Siddhartha Kar Dept. of Oncology 
Molecular mechanisms of DNA repair and replication in health and disease.   Dr Luca Pellegrini Dept of Biochemistry
MYC translocation in aggressive B-cell lymphomas: why partner matters? * Prof. Ming Qing Du Dept of Pathology
Post-transcriptional regulation of Aurora kinase in the cell cycle and cancer.  Dr Catherine Lindon Dept of Pharmacology
T cell synergy in anti-tumour responses. * Dr Arianne Richard Babraham Institute
Telomere maintenance, ageing and leukaemia prevention.  Prof George Vassiliou  Cambridge Stem Cell Institute (Haematology)  
The impact of age, parity and germline mutations on mammary gland development at the single cell level. * Dr Walid Khaled Cambridge Stem Cell Institute (Pharmacology) 
The role and regulation of membrane electric potential in migratory cells.  Dr Fengzhu Xiong Dept of Physiology, Development and Neuroscience
Innate immune control of kidney cancer * Prof James Nathan  Dept of Medicine
Mechanomodulation of mutant clonal competition; relevance for early tumour formation  Dr Maria Alcolea Dept of Physiology, Development and Neuroscience
Impact of trisomy 21 on the dynamics of human foetal haematopoiesis and leukaemia predisposition  Prof Elisa Laurenti  Cambridge Stem Cell Institute (Haematology) 

* Projects marked with asterix are  available for  Part-Time Clinical MRes rotations