Thu 05 Sep 13:00: Identifying therapeutic opportunities in the metabolic crosstalk between the tumour and the host

Identifying therapeutic opportunities in the metabolic crosstalk between the tumour and the host

Karen Vousden, Loic Mervant, Vassilis Papalazarou and Eric Cheung

The Francis Crick Institute, London NW1 1AT , UK

The environment in which a cancer develops has a significant impact on the success of malignant progression and will determine the requirements and vulnerabilities of the tumour, particularly as the environment changes during metastatic dissemination. We have been exploring the how metabolic changes and increased ROS in cancer cells drive both cell intrinsic and cell extrinsic effects, to promote tumour-supporting alterations in the tumour microenvironment (TME). Tumour-derived signals also affect whole body metabolism to induce nutrient release from fat and muscle and to prime metastasis niches to be more welcoming to disseminating cancer cells. Understanding and modulating the crosstalk between the tumour and the body may lead to new therapeutic options and provide novel circulating biomarkers to detect and follow cancer development.

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Link to talks.cam: 
http://talks.cam.ac.uk/talk/index/209944