Cambridge Cancer Centre Annual Symposium 2016

Cambridge Cancer Centre Symposium will take place on Monday 6 June at the CRUK Cambridge Institute.

The ninth annual Cambridge Cancer Centre Symposium will take place on Monday 6 June from 9.00-18.00 at the Cancer Research UK Cambridge Institute.

We are delighted to welcome Professor Ben Ebert (Harvard Medical School) and Professor Paul Workman (The Institute of Cancer Research) as our keynote speakers.

The programme for the day also includes highly-respected speakers from across the Cancer Centre, a debate chaired by Richard Gilbertson, short talks and a poster session, followed by drinks and a barbecue.

08:30-09:00

Registration and Coffee

09:00

Welcome and introduction – Tony Green, Wellcome Trust-MRC Cambridge Stem Cell Institute/Department of Haematology

09:10

Keynote Speaker – Ben Ebert, Harvard Medical School
Targeting ubiquitin ligases for the treatment of cancer

 

Session 1 Chair: Tony Green, Wellcome Trust-MRC Cambridge Stem Cell Institute/Department of Haematology

09:50

Ultan McDermott, Wellcome Trust Sanger Institute
Defining the mutational resistance landscape in cancer using chemical mutagenesis

10:10

Peter Campbell, Wellcome Trust Sanger Institute
Interrogating the architecture of cancer genomes

10:30

Tea/Coffee 

11:00

Brian Huntly, Department of Haematology  
Epigenetic dysregulation in haematological malignancies

11:20

Anna Philpott, Department of Oncology
Balancing cell cycling versus differentiation in normal and cancer cells

11:40

Short Talk Gianmarco Contino, MRC Cancer Unit
Analysis of structural variants of oesophageal adenocarcinoma reveals multiple hits in cell-cell communication pathway

11:55

Within the next 10 years, immunotherapy will be the mainstay of cancer treatment
Debate chaired by Richard Gilbertson, Cambridge Cancer Centre
Speakers: Gerard Evan, Department of Biochemistry and James Brenton, Cancer Research UK Cambridge Institute

12:40

Lunch and poster session

 

Session 2 Chair: Greg Hannon, Cancer Research UK Cambridge Institute

13:40

George Vassiliou,  Wellcome Trust Sanger Institute
Identifying genetic vulnerabilities in acute myeloid leukaemia using CRISPR drop-out screens

14:00

Wolf Reik, Babraham Institute
Epigenetic dynamics in single cells

14:20

Elisa Laurenti, Wellcome Trust-MRC Cambridge Stem Cell Institute
Transcriptional regulation of human haematopoietic stem cells

14:40

Meri Huch, Wellcome Trust-CRUK Gurdon Institute
Adult tissue progenitors and organoid cultures for the study of human biology and disease

15:00

Short Talk  Dezső Modos, Department of Chemistry
Neighbours of cancer-related proteins have key influence on pathogenesis and increase the drug target space for anti-cancer therapies

15:15

Short Talk Juan Garaycoechea, MRC Laboratory of Molecular Biology
Aldehydes mutate the genome of blood stem cells

15:30

Tea/Coffee

 

Session 3 Chair: Richard Gilbertson, Cambridge Cancer Centre

16:00

Bertie Göttgens, Wellcome Trust-MRC Cambridge Stem Cell Institute
Defining Stem Cell States and Regulatory Networks using Single Cell Genomics

16:20

Gerard Evan, Department of Biochemistry
Killing cancers by targeting their engines, not their drivers

16:40

Short Talk Athena Matakidou, Cancer Research UK Cambridge Institute
Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis

16:55

Short Talk Marco Ranzani, Wellcome Trust Sanger Institute
Identification of new therapies for the treatment of BRAF/NRAS wild type melanomas by functional screening approaches

17:10

Keynote speaker – Paul Workman, The Institute of Cancer Research
Discovering drugs and chemical probes for the cancer genome and malignant state

17:50

Drinks and poster session, followed by barbecue

Registration has now closed for the meeting but if you would like to be added to the waiting list please email Katie.Edwards@cruk.cam.ac.uk. 

2 Mar 2016