International Journal of Cancer - Richard Hardwick
Abstract: Cancers occurring at the gastro-esophageal junction (GEJ) are classified as predominantly esophageal or gastric, which is often difficult to decipher. We hypothesised that the transcriptomic profile might reveal molecular subgroups which could help to define the tumor origin and behaviour beyond anatomical location. The gene expression profiles of 107 treatment-naïve, intestinal type, gastro-esophageal adenocarcinomas were assessed by the Illumina-HTv4.0 beadchip. Differential gene expression (limma), unsupervised subgroup assignment (mclust), and pathway analysis (gage) were undertaken in R statistical computing and results were related to demographic and clinical parameters....
3 May 2019
