Clinical research on radiotherapy treatment

Radiotherapy is a treatment where radiation is used to kill cancer cells. It can be used to either cure the cancer (radical treatment) or to help relieve symptoms when a cure is not possible (palliative treatment). Radiotherapy is considered the most effective cancer treatment after surgery.

Research is continuing to try to improve radiotherapy treatments and reduce side effects.

Radiotherapy trials

Radiotherapy trials can be used to:

  • Identify the optimum treatment dose that gives greatest tumour control and minimal side effects
  • Explore new techniques and technologies
  • Explore its role when combined with other treatments such as chemotherapy and surgery.

The CCTC works closely with the Addenbrooke’s radiotherapy department. Addenbrooke’s houses one of the top-rated radiotherapy services in the UK. The department sees over 200 patients a day and is a specialist referral centre for many of the rarer cancers. This means that, as well as local patients, they see patients from across the region and the UK.

Current open trials in Cambridge

The radiotherapy trials team cross-cover many different treatment sites. If you are a patient and want to know more about radiotherapy trials relevant to you, please click on the relevant treatment site.

Titlesort ascending Trial description Contact name Trial end date Trial start date Trial tumour type
SARON Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial Dr Alex Martin 4 Jul 2023 9 Aug 2017 Lung
ROAM Radiation versus observation following surgical resection of atypical meningioma: A randomised controlled trial Dr Sarah Jefferies 30 Apr 2025 17 Nov 2016 Brain and CNS
PLATO PersonaLising Anal cancer radioTherapy dOse Dr Catherine Jephcott 31 Dec 2022 22 Mar 2017 Colorectal
PACE-C International randomised study of prostatectomy vs stereotactic body radiotherapy (SBRT) and conventional radiotherapy vs SBRT for organ-confined prostate cancer Dr Alex Martin 26 Apr 2026 5 Feb 2020 Prostate
EMBRACE-II Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer Dr Li Tee Tan 30 Jun 2024 7 Nov 2017 Gynaecological
CompARE Trial Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer Dr Rashmi Jadon 31 Jan 2026 5 Mar 2019 Head & neck
Best-Of Phase III study assessing the "Best-Of" radiotherapy compared to the "Best-Of" surgery (trans-oral surgery (TOS) in patients with T1-T2, N0 oropharyngeal carcinoma Dr Ekpemi Irune 1 Jan 2026 17 Nov 2020 Head & neck
ABC-07 Addition of stereotactic radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers Dr Thankamma Ajithkumar 31 Aug 2023 5 Apr 2017 Liver & Bile Duct