Title Trial description Contact name Trial end datesort descending Trial start date Trial tumour type
MDV3800-06 A Phase 2, Open-Label, 2-Arm, Response Rate Study of Talazoparib in Men With DNA Repair Defects and Metastatic Castration-Resistant Prostate Cancer Who Previously Received Taxane-Based Chemotherapy and Progressed on at Least 1 Novel Hormonal Agent (Enzalutamide and/or Abiraterone Acetate/Prednisone) Dr Danish Mazhar 30 Apr 2019 18 Oct 2017 Prostate
INTERIM a randomised phase II feasibility study of INTERmittent versus continuous dosing of oral targeted combination therapy In patients with BRAFV600 mutant stage 3 unresectable or metastatic Melanoma Dr Pippa Corrie 30 Apr 2019 3 Nov 2017 Skin & melanoma
GLOW A Randomized, Open-label Phase 3 study of the Combination of Ibrutinib plus Venetoclax versus Chlorambucil plus Obinutuzumab for the First-line Treatment of Subjects with Chronic Lymphocytic Leukaemia (CLL)/Small Lymphocytic Lymphoma (SLL) Dr George Follows 30 Apr 2019 28 Jun 2018 Haematological
Pharmacyclics PCYC 1141 (Bruton's Tyrosine Kinase Inhibitor, Treatment for Follicular Lymphoma) A Multicentre, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton’s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination with Rituximab versus Placebo in Combination with Rituximab in Treatment Naïve Subjects with Follicular Lymphoma Dr George Follows 31 May 2019 27 Jul 2018 Haematological
Euro Ewing 2012 International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing's Sarcoma Family of Tumours Dr Denise Williams 31 May 2019 30 Apr 2015 Sarcoma
Developing and validation SAM Study to develop and validate a sarcoma-specific outcome questionnaire: the Sarcoma Assessment Measure (SAM): , PHASE 2 Dr Helen Hatcher 31 May 2019 18 Mar 2019 Sarcoma
COMBI-Aplus Open-label, phase IIIb study of dabrafenib in combination with trametinib in the adjuvant treatment of stage III BRAF V600 mutation-positive melanoma after complete resection to evaluate the impact on pyrexia related outcomes of an adapted pyrexia AE-management algorithm Dr Pippa Corrie 31 Jul 2019 7 Sep 2018 Skin & melanoma
ICON8B  A phase III randomised trial investigating the combination of dose-fractionated chemotherapy & bevacizumab compared to either strategy alone for the first line treatment of women with newly diagnosed high risk stage III-IV epithelial ovarian, fallopian tube or primary peritoneal cancer Dr Christine Parkinson 31 Jul 2019 8 Feb 2012 Gynaecological
SMS Study Study of Somatic Sutations using genome Sequencing Dr Philip Jones 1 Aug 2019 18 Oct 2015 Skin & melanoma
PRECISION-Panc Advancing personalised medicine treatment strategies for pancreatic cancer Dr Bristi Basu 29 Aug 2019 25 Apr 2018 Pancreatic
PRIMUS-001 An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation Dr Pippa Corrie 30 Aug 2019 10 May 2018 Pancreatic
SEAL A Phase 2-3, multicenter, randomized, doubleblind study of selinexor (KPT-330) versus placebo in patients with advanced unresectable dedifferentiated liposarcoma (DDLS) Dr James Robin 31 Aug 2019 7 Nov 2018 Sarcoma
NAXIVA Phase II Neoadjuvant study of AXItinib for reducing extent of venous tumour thrombus in clear cell renal cell cancer with Venous invAsion Dr Grant Stewart 30 Sep 2019 4 Dec 2017 Kidney
Cambridge Prostate Biopsy Device: CAMPROBE Developing a safer and more accurate device for biopsies of suspected cancer Mr Vincent Gnanapragasam 30 Sep 2019 2 Feb 2016 Prostate
GO39942 (Polarix) A Phase III, Multicenter, Randomized, Double-blind, Placebo-Controlled Trial Comparing the Efficacy and Safety of Polatuzumab Vedotin in Combination With Rituximab and CHP (R-CHP) Versus Rituximab and CHOP (R-CHOP) in Previously Untreated Patients With Diffuse Large B-Cell Lymphoma (DLBCL) Dr George Follows 30 Oct 2019 16 Nov 2018 Haematological
RENA 4970 (The Water Study) Waterjet Ablation Therapy for Endoscopic Resection of prostate tissue Mr Tevita Aho 30 Nov 2019 4 Feb 2016 Prostate
HGUSStudy A randomized double-blind phase II study evaluating the role of maintenance therapy with cabozantinib in High Grade Undifferentiated Uterine Sarcoma (HGUS) after stabilization or response to doxorubicin +/- ifosfamide following surgery or in metastatic first line treatment Dr Helen Hatcher 30 Dec 2019 11 Mar 2016 Sarcoma
Artist 1 A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared with FOLFOX Alone as Second-line Therapy in Patients with Metastatic Pancreatic Cancer that has Progressed During or Following a First-Line Gemcitabine Containing Regimen Dr Pippa Corrie 30 Dec 2019 21 Jul 2017 Pancreatic
TAMARIN Effects of Tamoxifen on the Mutant Allele Burden and Disease Course in Patients with MyeloproliferatIve Neoplasms Dr Anna Godfrey 31 Dec 2019 14 Dec 2016 Haematological
PRaM-GBM Predicting sites of tumour progression in the invasive margin of glioblastomas Mr Stephen Price 31 Dec 2019 1 Feb 2017 Brain and CNS
POPS A randomised phase II trial assessing Post-Operative use of ProSpare, a rectal obturator in prostate cancer radiotherapy Dr Yvonne Rimmer 31 Dec 2019 4 Jul 2017 Prostate
The Causes of Clonal Blood Cell Disorders The Causes of Clonal Blood Cell Disorders Professor Tony Green 31 Dec 2019 1 Jan 2008 Haematological
LI-1 Leukaemia Lymphoma Research and NCRI Working Group Pick a Winner Programme (LI1) Trial Dr Jenny Craig 31 Dec 2019 17 Feb 2014 Haematological
PHAZAR A phase Ib study to assess the safety and tolerability of oral Ruxolitinib in combination with 5-azacitidine in patients with advanced phase MyeloproliferatIve neoplasms (MPN), including myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML) arising from MPN. Dr Anna Godfrey 31 Dec 2019 12 Jun 2018 Haematological
PIANO Study PLX3397 A Phase II Trial of PLX3397 in the Treatment of KIT Mutated Advanced Acral and Mucosal Melanoma Dr Christine Parkinson 31 Dec 2019 4 Apr 2016 Skin & melanoma
PRISM A randomised phase II trial of nivolumab in combination with alternatively scheduled ipilimumab in first-line treatment of patients with advanced or metastatic renal cell carcinoma Dr Kate Fife 31 Dec 2019 6 Jun 2018 Kidney
IoN IoN Is ablative radio-iodine necessary for low risk differentiated thyroid cancer patients Dr Sarah Jefferies 31 Dec 2019 28 Nov 2012 Head & neck
UKALL 14 A randomized trial for adults with newly diagnosed acute lymphoblastic leukaemia Dr Jenny Craig 31 Dec 2019 31 Jul 2012 Haematological
DIG (Diffusion imaging in gliomas) Quantitative diffusion imaging for early treatment response and progression evaluation in adult high grade gliomas; a multicentre study Dr Tomasz Matys 31 Dec 2019 13 Jul 2018 Brain and CNS
SHAPE A randomized phase III trial comparing radical hysterectomy and pelvic node dissection versus simple hysterectomy and pelvic node dissection in patients with low-risk early-stage cervical cancer Mr Robin Crawford 11 Jan 2020 11 Jan 2016 Gynaecological
Gravitas A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Itacitinib or Placebo in Combination With Corticosteroids for the Treatment of First-Line Acute Graft Versus-Host Disease Dr Pramila Krishnamurthy 31 Jan 2020 30 May 2018 Haematological
FLAIR Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab Dr George Follows 4 Feb 2020 19 Jan 2015 Haematological
Ariel 4 (CANC 5651) A Phase 3 Multicenter, Open-label, Randomized Study of Rucaparib versus Chemotherapy in Patients with Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Dr James Brenton 11 Apr 2020 11 Apr 2017 Gynaecological
rEECur International randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma Dr Denise Williams 30 Apr 2020 5 May 2016 Sarcoma
PARADIGM Phase II Short-course radiotherapy plus olaparib for newly diagnosed glioblastoma in patients unsuitable for radical chemoradiation: a randomised phase II clinical trial preceded by a lead-in phase I dose escalation study Dr Sarah Jefferies 30 Apr 2020 4 Nov 2016 Brain and CNS
MDS Registry for newly diagnosed patients A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes Professor Alan Warren 1 May 2020 16 Feb 2009 Haematological
UK P3BEP Trial A randomised phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumours Dr Danish Mazhar 30 Jun 2020 5 May 2017 Testicular
IpiGlio A Phase II, open label, randomised study of ipilimumab with temozolomide versus temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma Dr Fiona Harris 31 Jul 2020 21 Jan 2019 Brain and CNS
MK3475-716 Adjuvant therapy with pembrolizumab versus placebo in resected stage II melanoma: a randomized, double-blind phase III study Dr Pippa Corrie 31 Jul 2020 25 Oct 2018 Skin & melanoma
PIVOTALboost A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost. Dr Yvonne Rimmer 17 Aug 2020 7 Mar 2018 Prostate
Neo-AEGIS Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction Dr Hugo Ford 1 Sep 2020 24 Nov 2015 Oesophageal
STAMPEDE Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy Dr Danish Mazhar 6 Sep 2020 1 Aug 2018 Prostate
PEACE The PEACE (Posthumous tissuE donAtion in CancEr) Study Dr James Brenton 8 Oct 2020 8 Oct 2018 Gynaecological, Breast
Keynote 775 A Multicenter, Open-label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib in Combination with Pembrolizumab Versus Treatment of Physician’s Choice in Participants with Advanced Endometrial Cancer Dr Christine Parkinson 17 Oct 2020 17 Oct 2018 Gynaecological
Mediola A Phase I/II Study of MEDI4736 (Anti-PD-L1 Antibody) in Combination with Olaparib (PARP inhibitor) in Patients with Advanced Solid Tumors Dr Christine Parkinson 18 Oct 2020 18 Oct 2018 Gynaecological
MDS AZA 003 A phase 3, multicentre, randomized, double-blind study to compare with efficacy and safety of oral azacitidine plus best supportive care versus placebo plus best supportive care in subjects with red blood cell transfusion-dependent anemia and thrombocytopenia due to IPSS lower-risk myelodysplatic syndromes Dr Theodora Foukaneli 30 Oct 2020 27 Oct 2014 Haematological
OPTIMA Optimal Personalised Treatment of early breast cancer using Multiparameter Analysis Dr Luke Hughes-Davies 31 Oct 2020 25 Oct 2012 Breast
FOCUS 4 FOCUS4 – Molecular selection of therapy in colorectal cancer: a molecularly stratified randomised controlled trials programme Dr Hugo Ford 25 Nov 2020 1 Dec 2015 Colorectal
Add-Aspirin Trial A phase III, double blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours Dr Luke Hughes-Davies 11 Dec 2020 21 Dec 2015 Breast, Colorectal, Oesophageal, Prostate
Cabozantinib in patients with advanced renal cell carcinoma a non-interventional retrospective study to describe early clinical experience with cabozantinib in patients with advanced renal cell carcinoma in the uk Dr Kate Fife 18 Dec 2020 18 Dec 2018 Kidney
UTX-TGR-205 (Unity NHL) A Phase 2b Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + TGR-1202 with or without Bendamustine and TGR-1202 alone in Patients with Previously Treated Non-Hodgkin’s Lymphoma. Dr Dan Hodson 29 Dec 2020 29 Dec 2017 Haematological
AML 18 A Trial for Older Patients with Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome Dr Jenny Craig 31 Dec 2020 7 Dec 2015 Haematological
plasmaMATCH A multiple parallel cohort, non-randomised, open label, multi-centre phase IIa clinical trial aiming to provide proof of principle efficacy for designated targeted therapies in patients with advanced breast cancer where the targetable mutation is identified through ctDNA screening Dr Richard Baird 31 Dec 2020 11 Apr 2017 Breast
MEASURES The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Dr Anna Godfrey 31 Dec 2020 12 Jul 2017 Haematological
National Lung Matrix Trial Multi-­drug, genetic marker-directed, non­-comparative, multi-­centre, multi­-arm phase II trial in non-small cell lung cancer Dr David Gilligan 31 Dec 2020 17 Nov 2015 Lung
SSGXXII Three versus five years of adjuvant imatinib as treatment of patients with operable GIST with a high risk for recurrence: A randomised phase III study Dr Ramesh Bulusu 31 Dec 2020 1 Mar 2017 Sarcoma
Cervical Cell Lift Collection of Cervical Cells at Colposcopy using a novel technique for analysis of high risk vs. low risk lesions Dr Robin Crawford 31 Dec 2020 14 Jul 2017 Gynaecological
BRITER Brain Imaging to predict Toxicity in Elderly patients after Radiotherapy Dr Gary Doherty 31 Mar 2021 10 Jan 2019 Brain and CNS
PARTNER Randomised, phase II/III, 3 stage trial to evaluate the safety and efficacy of the addition of olaparib to platinum-based neoadjuvant chemotherapy in breast cancer patients with TNBC and/or gBRCA Dr Jean Abraham 31 Mar 2021 12 May 2016 Breast
Minitub Registration Study (EORTC 1208)  Prospective registry of Sentinel Node (SN) positive melanoma patients with minimal SN tumor burden who undergo Completion Lymph Node Dissection (CLND) or Nodal Observation Dr Amer Durrani 1 May 2021 19 Oct 2017 Skin & melanoma
BMS Retrospective RCC Study Estimating health outcomes in patients with advanced or Metastatic Renal Cell Carcinoma (mRCC) treated with systemic therapy, using real-world data - CA209671 Dr Kate Fife 30 Jul 2021 22 Mar 2017 Kidney
EuroNet-PHL-C2 Second International Inter-Group Study for Classical Hodgkin's Lymphoma in Children and Adolescents Dr Ben Uttenthal 30 Sep 2021 30 Oct 2018 Haematological
MyeChild 01 International Randomised Phase III Clinical Trial in Children with Acute Myeloid Leukaemia - Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination with Induction Chemotherapy Dr Michael Gattens 1 Nov 2021 31 Oct 2016 Haematological
AML 19 Adults with acute myeloid leukaemia or high-risk myelodysplastic syndrome Dr Jenny Craig 9 Nov 2021 15 Oct 2015 Haematological
Target Fal01 Translational Analysis and Research in Gynaecological Epithelial Tissues - Fallopian Tubes Dr Filipe Correia Martins 30 Nov 2021 11 Jan 2019 Gynaecological
ADSCaN A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-small Cell Lung Cancer Dr Susan Harden 31 Dec 2021 23 Nov 2017 Lung
Myeloma XII A phase III study to determine the role of ixazomib as an Augmented Conditioning therapy in salvage autologous stem Dr Charles Crawley 31 Dec 2021 22 May 2017 Haematological
SPECTA (EORTC 1553) Screening cancer patients for efficient clinical trial access Dr Helen Hatcher 31 Dec 2021 1 Aug 2018 Sarcoma
PRIMETIME Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers Dr Charlotte Coles 31 Dec 2021 18 May 2017 Breast
FAST-Forward FAST Forward is a randomised clinical trial testing a 1-week course of curative whole breast radiotherapy against a standard 3-week schedule in terms of local cancer control and late adverse effects in patients with early breast cancer. The lymphatic RT sub-study an extension to the FAST-Forward trial, which maintains its original design but whose entry is now restricted to patients prescribed radiotherapy to level I-III axilla and/or level IV axilla (supraclavicular fossa (SCF)) in addition to the breast/chest wall area. Dr Charlotte Coles 1 Feb 2022 12 Mar 2012 Breast
Quality of Life After Bladder Cancer (Q-ABC) A comparison of patient related outcomes following radical surgery and radiotherapy Dr Yvonne Rimmer 1 Mar 2022 23 Oct 2018 Bladder
PLATO PersonaLising Anal cancer radioTherapy dOse Dr Catherine Jephcott 31 Dec 2022 22 Mar 2017 Colorectal
ALF Research Study Research into Altered Lymphocyte Function in Health and Disease Dr Kate Fife 31 Dec 2022 9 Nov 2017 Skin & melanoma
Athena A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy Dr Christine Parkinson 31 Mar 2023 27 Mar 2019 Gynaecological
Dante A randomised phase III trial to evaluate the duration of anti-PD1 monoclonal antibody treatment in patients with metastatic melanoma Dr Pippa Corrie 31 Mar 2023 21 Sep 2018 Skin & melanoma
SARON Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial Dr Susan Harden 4 Jul 2023 9 Aug 2017 Lung
ABC-07 Addition of stereotactic radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers Dr Thankamma Ajithkumar 31 Aug 2023 5 Apr 2017 Liver & Bile Duct
RAMPART Renal Adjuvant MultiPle Arm Randomised Trial (RAMPART): An international investigator-led phase III multi-arm multi-stage multi-centre randomised-controlled platform trial of adjuvant therapy in patients with resected primary renal cell carcinoma (RCC) at high or intermediate risk of relapse Dr Sarah Welsh 31 Dec 2023 20 Jul 2018 Kidney
EMBRACE-II Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer Dr Li Tee Tan 30 Jun 2024 7 Nov 2017 Gynaecological
CompARE Trial Phase III randomised controlled trial Comparing Alternative Regimens for escalating treatment of intermediate and high-risk oropharyngeal cancer Dr Rashmi Jadon 31 Jan 2026 5 Mar 2019 Head & neck
RAIDER A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder Dr Yvonne Rimmer 21 Mar 2029 6 Jan 2016 Bladder