Title Trial description Contact name Trial end datesort descending Trial start date Trial tumour type
NATT interNational Anaplastic Thyroid Cancer Tissue Bank and Database Project Dr Sarah Jefferies 20 Nov 2018 20 Nov 2013 Head & neck
Artist 1 A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared with FOLFOX Alone as Second-line Therapy in Patients with Metastatic Pancreatic Cancer that has Progressed During or Following a First-Line Gemcitabine Containing Regimen Dr Pippa Corrie 30 Dec 2018 21 Jul 2017 Pancreatic
Non-Hodgkin Lymphoma in Young Adults A prospective UK population based study of incidence, treatment and outcomes Dr Ben Uttenthal 31 Dec 2018 27 Oct 2016 Haematological
CR UK Stratified Medicine Pilot study The Cancer Research UK Stratified Medicine Programme: Pilot Study Professor VP Collings 31 Dec 2018 27 Jul 2011 Lung
National Lung Matrix Trial Multi-­drug, genetic marker-directed, non­-comparative, multi-­centre, multi­-arm phase II trial in non-small cell lung cancer Dr David Gilligan 31 Dec 2018 17 Nov 2015 Lung
plasmaMATCH A multiple parallel cohort, non-randomised, open label, multi-centre phase IIa clinical trial aiming to provide proof of principle efficacy for designated targeted therapies in patients with advanced breast cancer where the targetable mutation is identified through ctDNA screening Dr Richard Baird 31 Dec 2018 11 Apr 2017 Breast
MelResist Investigating resistance to gene-targeted melanoma therapies Dr Pippa Corrie 31 Dec 2018 3 Dec 2011 Skin & melanoma
Olympia / MA.36 A randomised, double-blind, parallel group, placebo-controlled multi-centre Phase III study to assess the efficacy and safety of olaparib versus placebo as adjuvant treatment in patients with germline BRCA1/2 mutations and high risk HER2 negative primary breast cancer who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy Dr Jean Abraham 23 Jan 2019 23 Jan 2015 Breast
ATOMIC-Meso Randomized, Double-Blind Phase 2/3 Study in Subjects with Malignant Pleural Mesothelioma with Low Argininosuccinate Synthetase 1 Expression to Assess ADI-PEG 20 with Pemetrexed and Cisplatin Dr David Gilligan 25 Jan 2019 5 Mar 2018 Lung
ESPAC-4 EUROPEAN STUDY GROUP FOR PANCREATIC CANCER - TRIAL 4. Combination versus single agent chemotherapy in resectable pancreatic ductal and peri-ampullary cancers Dr Pippa Corrie 28 Jan 2019 24 Jun 2009 Pancreatic
Quartus Quantification of breast radiotheraphy associated in late toxicity using novel ultrasound techniques Dr Charlotte Coles 31 Jan 2019 13 May 2016 Breast
FLAIR Front-Line therapy in CLL: Assessment of Ibrutinib + Rituximab Dr George Follows 4 Feb 2019 19 Jan 2015 Haematological
PATHOS A Phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV)-positive oropharyngeal cancer Dr Ekpemi Irune 28 Feb 2019 16 Jun 2017 Head & neck
ACELARATE A phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC-1031) with Gemcitabine in patients with metastatic pancreatic carcinoma Dr Pippa Corrie 14 Mar 2019 14 Mar 2016 Pancreatic
SCALOP-2 A multi-centre randomised study of induction chemotherapy followed by capecitabine (+/-nelfinavir) with high or standard dose radiotherapy for locally advanced non-metastatic pancreatic cancer Dr Thankamma Ajithkumar 21 Mar 2019 18 Aug 2016 Pancreatic
HALO (CANC - 4997) A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) in Combination With nab Paclitaxel Plus Gemcitabine Compared With Placebo Plus nab Paclitaxel and Gemcitabine in Subjects with Hyaluronan-High Stage IV Previously Untreated Pancreatic Cancer Dr Pippa Corrie 31 Mar 2019 16 Nov 2016 Pancreatic
ACTICCA-1 Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Observation After Curative Intent Resection of Biliary Tract Cancer Dr Pippa Corrie 1 Apr 2019 22 Jun 2016 Liver & Bile Duct
INTERIM a randomised phase II feasibility study of INTERmittent versus continuous dosing of oral targeted combination therapy In patients with BRAFV600 mutant stage 3 unresectable or metastatic Melanoma Dr Pippa Corrie 30 Apr 2019 3 Nov 2017 Skin & melanoma
MDV3800-06 A Phase 2, Open-Label, 2-Arm, Response Rate Study of Talazoparib in Men With DNA Repair Defects and Metastatic Castration-Resistant Prostate Cancer Who Previously Received Taxane-Based Chemotherapy and Progressed on at Least 1 Novel Hormonal Agent (Enzalutamide and/or Abiraterone Acetate/Prednisone) Dr Danish Mazhar 30 Apr 2019 18 Oct 2017 Prostate
Euro Ewing 2012 International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing's Sarcoma Family of Tumours Dr Denise Williams 31 May 2019 30 Apr 2015 Sarcoma
ICON8B  A phase III randomised trial investigating the combination of dose-fractionated chemotherapy & bevacizumab compared to either strategy alone for the first line treatment of women with newly diagnosed high risk stage III-IV epithelial ovarian, fallopian tube or primary peritoneal cancer Dr Christine Parkinson 31 Jul 2019 8 Feb 2012 Gynaecological
SMS Study Study of Somatic Sutations using genome Sequencing Dr Philip Jones 1 Aug 2019 18 Oct 2015 Skin & melanoma
CANC 5578 (B9991010) (Javelin100) A randomised, open-label, multicentre, phase 3 study to evaluate the efficacy and safety of Avelumab (MSB0010718C) in combination with and/or following chemotherapy in patients with previously untreated epithelial ovarian cancer Dr Christine Parkinson 28 Aug 2019 31 May 2016 Gynaecological
PRECISION-Panc Advancing personalised medicine treatment strategies for pancreatic cancer Dr Bristi Basu 29 Aug 2019 25 Apr 2018 Pancreatic
PRIMUS-001 An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation Dr Pippa Corrie 30 Aug 2019 10 May 2018 Pancreatic
NAXIVA Phase II Neoadjuvant study of AXItinib for reducing extent of venous tumour thrombus in clear cell renal cell cancer with Venous invAsion Dr Grant Stewart 30 Sep 2019 4 Dec 2017 Kidney
Cambridge Prostate Biopsy Device: CAMPROBE Developing a safer and more accurate device for biopsies of suspected cancer Mr Vincent Gnanapragasam 30 Sep 2019 2 Feb 2016 Prostate
ProCAID An open label phase I/randomised, double-blind phase II study in metastatic castration resistant Prostate Cancer of AZD5363 in combination with Docetaxel and prednisolone chemotherapy Dr Danish Mazhar 31 Oct 2019 14 Nov 2017 Prostate
RENA 4970 (The Water Study) Waterjet Ablation Therapy for Endoscopic Resection of prostate tissue Mr Tevita Aho 30 Nov 2019 4 Feb 2016 Prostate
HGUSStudy A randomized double-blind phase II study evaluating the role of maintenance therapy with cabozantinib in High Grade Undifferentiated Uterine Sarcoma (HGUS) after stabilization or response to doxorubicin +/- ifosfamide following surgery or in metastatic first line treatment Dr Helen Hatcher 30 Dec 2019 11 Mar 2016 Sarcoma
LI-1 Leukaemia Lymphoma Research and NCRI Working Group Pick a Winner Programme (LI1) Trial Dr Pramila Krishnamurthy 31 Dec 2019 17 Feb 2014 Haematological
IoN IoN Is ablative radio-iodine necessary for low risk differentiated thyroid cancer patients Dr Sarah Jefferies 31 Dec 2019 28 Nov 2012 Head & neck
POPS A randomised phase II trial assessing Post-Operative use of ProSpare, a rectal obturator in prostate cancer radiotherapy Dr Yvonne Rimmer 31 Dec 2019 4 Jul 2017 Prostate
PRISM A randomised phase II trial of nivolumab in combination with alternatively scheduled ipilimumab in first-line treatment of patients with advanced or metastatic renal cell carcinoma Dr Kate Fife 31 Dec 2019 6 Jun 2018 Kidney
rEECur International randomised controlled trial of chemotherapy for the treatment of recurrent and primary refractory Ewing sarcoma Dr Denise Williams 30 Apr 2020 5 May 2016 Sarcoma
MDS Registry for newly diagnosed patients A prospective, multicentre European Registry for newly diagnosed patients with Myelodysplastic Syndromes of IPSS low and intermediate-1 subtypes Professor Alan Warren 1 May 2020 16 Feb 2009 Haematological
PIVOTALboost A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost. Dr Yvonne Rimmer 17 Aug 2020 7 Mar 2018 Prostate
Neo-AEGIS Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (MAGIC regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction Dr Hugo Ford 1 Sep 2020 24 Nov 2015 Oesophageal
CORE A randomised trial of conventional care versus radioablation (stereotactic body radiotherapy) for extracranial metastases Dr Susan Harden 2 Sep 2020 29 Mar 2018 Lung, Breast, Prostate
NCRN525 (AZACITIDINE + BSC v PLACEBO + BSC) / AZA-MDS-003 A phase 3, multicentre, randomized, double-blind study to compare with efficacy and safety of oral azacitidine plus best supportive care versus placebo plus best supportive care in subjects with red blood cell transfusion-dependent anemia and thrombocytopenia due to IPSS lower-risk myelodysplatic syndromes Dr Theodora Foukaneli 30 Oct 2020 27 Oct 2014 Haematological
OPTIMA Optimal Personalised Treatment of early breast cancer using Multiparameter Analysis Dr Luke Hughes-Davies 31 Oct 2020 25 Oct 2012 Breast
FOCUS 4 FOCUS4 – Molecular selection of therapy in colorectal cancer: a molecularly stratified randomised controlled trials programme Dr Hugo Ford 25 Nov 2020 1 Dec 2015 Colorectal
Add-Aspirin Trial - Breast A phase III, double blind, placebo controlled, randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours Dr Luke Hughes-Davies 11 Dec 2020 21 Dec 2015 Breast, Colorectal, Oesophageal, Prostate
PARTNER Randomised, phase II/III, 3 stage trial to evaluate the safety and efficacy of the addition of olaparib to platinum-based neoadjuvant chemotherapy in breast cancer patients with TNBC and/or gBRCA Dr Jean Abraham 31 Mar 2021 12 May 2016 Breast
BMS Retrospective RCC Study Estimating health outcomes in patients with advanced or Metastatic Renal Cell Carcinoma (mRCC) treated with systemic therapy, using real-world data - CA209671 Dr Kate Fife 30 Jul 2021 22 Mar 2017 Kidney
MyeChild 01 International Randomised Phase III Clinical Trial in Children with Acute Myeloid Leukaemia - Incorporating an Embedded Dose Finding Study for Gemtuzumab Ozogamicin in Combination with Induction Chemotherapy Dr Michael Gattens 1 Nov 2021 31 Oct 2016 Haematological
SPECTA (EORTC 1553) Screening cancer patients for efficient clinical trial access Dr Helen Hatcher 31 Dec 2021 1 Aug 2018 Sarcoma
ADSCaN A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-small Cell Lung Cancer Dr Susan Harden 31 Dec 2021 23 Nov 2017 Lung
PRIMETIME Post-operative avoidance of radiotherapy in minimal risk women: patient selection using biomarkers Dr Charlotte Coles 31 Dec 2021 18 May 2017 Breast
Myeloma XII (ACCoRd trial) Version 1.0 A phase III study to determine the role of ixazomib as an Augmented Conditioning therapy in salvage autologous stem Dr Charles Crawley 31 Dec 2021 22 May 2017 Haematological
FAST-Forward FAST Forward is a randomised clinical trial testing a 1-week course of curative whole breast radiotherapy against a standard 3-week schedule in terms of local cancer control and late adverse effects in patients with early breast cancer. The lymphatic RT sub-study an extension to the FAST-Forward trial, which maintains its original design but whose entry is now restricted to patients prescribed radiotherapy to level I-III axilla and/or level IV axilla (supraclavicular fossa (SCF)) in addition to the breast/chest wall area. Dr Charlotte Coles 1 Feb 2022 12 Mar 2012 Breast
Quality of Life After Bladder Cancer (Q-ABC) A comparison of patient related outcomes following radical surgery and radiotherapy Dr Yvonne Rimmer 1 Mar 2022 23 Oct 2018 Bladder
ALF Research Study Research into Altered Lymphocyte Function in Health and Disease Dr Kate Fife 31 Dec 2022 9 Nov 2017 Skin & melanoma
Rational MCC Rational treatment selection for Merkel Cell Carcinoma (MCC): A randomised phase III multi-centre trial comparing radical surgery and radical radiotherapy as first definitive treatment for primary MCC with an observational study for patients ineligible for the randomised trial. Dr Kate Fife 31 Dec 2022 22 Dec 2016 Skin & melanoma
PLATO PersonaLising Anal cancer radioTherapy dOse Dr Catherine Jephcott 31 Dec 2022 22 Mar 2017 Colorectal
SARON Stereotactic ablative radiotherapy for oligometastatic non-small cell lung cancer. A randomised phase III trial Dr Susan Harden 4 Jul 2023 9 Aug 2017 Lung
ABC-07 Addition of stereotactic radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers Dr Thankamma Ajithkumar 31 Aug 2023 5 Apr 2017 Liver & Bile Duct
RAMPART Renal Adjuvant MultiPle Arm Randomised Trial (RAMPART): An international investigator-led phase III multi-arm multi-stage multi-centre randomised-controlled platform trial of adjuvant therapy in patients with resected primary renal cell carcinoma (RCC) at high or intermediate risk of relapse Dr Sarah Welsh 31 Dec 2023 20 Jul 2018 Kidney
EMBRACE-II Image guided intensity modulated External beam radiochemotherapy and MRI based adaptive BRAchytherapy in locally advanced CErvical cancer Dr Li Tee Tan 30 Jun 2024 7 Nov 2017 Gynaecological
RAIDER A Randomised phase II trial of Adaptive Image guided standard or Dose Escalated tumour boost Radiotherapy in the treatment of transitional cell carcinoma of the bladder Dr Yvonne Rimmer 21 Mar 2029 6 Jan 2016 Bladder