Professor Andrea Brand

University of Cambridge

University departments: 
Department of Physiology, Development and Neuroscience
University institutes: 
Wellcome Trust CRUK Gurdon Institute

Position: Professor
Personal home page: https://www.gurdon.cam.ac.uk/research/brand
Email:   a.brand@gurdon.cam.ac.uk

PubMed journal articles - click here

Professor Andrea Brand is pleased to consider applications from prospective PhD students.

Research Programme or Virtual Institute: 
Fundamental Biology of Cancer
Methods and technologies: 
Bioinformatics
Calcium imaging
Confocal microscopy
DNA sequencing
Fluorescence microscopy
Gene expression profiling
Genomics
Imaging
Immunohistochemistry
In situ hybridization
In vivo modelling
Microscopy
Model organisms
Nutrition
PCR
RNAi
Tumour type interests: 
Brain and central nervous system
Keywords: 
Neural stem cell
niche
glia
ahb1000
Recent publications:
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Key publications: 

van den Ameele, J. and Brand, A.H. (2019). Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation.
Elife. 2019 Sep 12;8. pii: e47887. doi: 10.7554/eLife.47887.

Otsuki, L. and Brand, A.H. (2019). Dorsal-ventral differences in neural stem cell quiescence are induced by p57KIP2/Dacapo. Developmental Cell, 49, 293-300.

Otsuki, L. and Brand, A.H. (2018). Cell cycle heterogeneity directs the timing of neural stem cell activation from quiescence. Science 360, 99-102.

Cheetham, S.W. and Brand, A.H. (2018). RNA-DamID reveals cell-type-specific binding of roX RNAs at chromatin-entry sites. Nature Structural and Molecular Biology 25, 109-114.

Cheetham, S.W., Gruhn, W.H., van den Ameele, J., Krautz, R., Southall, T.D., Kobayashi, T., Surani, M.A. and Brand, A.H. (2018). Targeted DamID reveals differential binding of mammalian pluripotency factors. Development 145(20). doi: 10.1242/dev.170209.

Hakes, A.E., Otsuki, L. and Brand, A.H. (2018). A newly discovered neural stem cell population is generated by the optic lobe neuroepithelium during embryogenesis in Drosophila melanogaster. Development 145(18). doi: 10.1242/dev.166207.

Spéder, P. and Brand, A.H. (2018). Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila. eLife 4;7. doi: 10.7554/eLife.30413.

Marshall, O.J. and Brand, A.H. (2017). Chromatin state changes during neural development revealed by in vivo cell-type specific profiling. Nature Communications 8(1), 2271.

Southall, T.D., Davidson, C.M., Miller, C., Carr, A. and Brand, A.H. (2014). Dedifferentiation of neurons precedes tumour formation in lola mutants. Developmental Cell 28, 685-96.

Drosophila as a cancer model: We showed that neurons mutant for the gene lola (outlined in green) revert to a stem cell-like fate (red) and generate brain tumours in adults (arrowed; brain outlined in cyan).