Professor Antonis Antoniou

University of Cambridge
Department of Public Health and Primary Care
Strangeways Research Laboratory

Position: Professor
Personal home page:

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Professor Antonis Antoniou is pleased to consider applications from prospective PhD students.

Research description

My research interests involve the development and application of statistical modelling techniques to the inherited susceptibility of cancer, in particular breast, ovarian and other common cancers. Research focuses on two broad areas: the development and evaluation of risk prediction models for familial breast, ovarian, prostate and other cancers with a familial component; and the identification and characterisation of modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers through analysis of large scale genome-wide and candidate gene association studies.

Research Programme
Ovarian Cancer
Recent publications:
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Key publications

Jervis, S., Song, H., Lee, A., Dicks, E., Harrington, P., Baynes, C., Manchanda, R., Easton, D.F., Jacobs, I., Pharoah, P.D., and Antoniou, A.C. (2015). A Risk Prediction Algorithm for Ovarian Cancer Incorporating BRCA1, BRCA2, Common Alleles and Other Familial Effects. J Med Genet 52(7):465-75 DF Easton, PD Pharoah, AC Antoniou, M Tischkowitz, SV Tavtigian, KL Nathanson, P Devilee, A Meindl, FJ Couch, M Southey, DE Goldgar, DG Evans, G Chenevix-Trench, N Rahman, M Robson, SM Domchek, WD Foulkes. Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk. N. Engl. J. Med. 2015. Kuchenbaecker, K.B., Ramus, S.J.,?, Pharoah, P.P., Antoniou, A.C.*, and Chenevix-Trench, Kuchenbaecker, K.B., Ramus, S.J.,?, Pharoah, P.P., Antoniou, A.C.*, and Chenevix-Trench, G.* (2015). Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nature genetics 47, 164-171 Antoniou AC, Casadei S, Heikkinen T, Barrowdale D, Pylkäs K, Roberts J, Lee A, Subramanian D, De Leeneer K, Fostira F, Tomiak E, Neuhausen SL, Teo ZL, Khan S, Aittomäki K, Moilanen JS, Turnbull C, Seal S, Mannermaa A, Kallioniemi A, Lindeman GJ, Buys SS, Andrulis IL, Radice P, Tondini C, Manoukian S, Toland AE, Miron P, Weitzel JN, Domchek SM, Poppe B, Claes KB, Yannoukakos D, Concannon P, Bernstein JL, James PA, Easton DF, Goldgar DE, Hopper JL, Rahman N, Peterlongo P, Nevanlinna H, King MC, Couch FJ, Southey MC, Winqvist R, Foulkes WD, Tischkowitz M. (2015). Breast-cancer risk in families with mutations in PALB2. N Engl J Med. 2014 Aug 7;371(6):497-506 Kuchenbaecker, K., Neuhausen, S?., Antoniou, A.C., and CIMBA. (2014). Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research 16, 3416. Lee AJ, Cunningham AP, Kuchenbaecker KB, Mavaddat N, Easton DF, Antoniou AC (2014) BOADICEA breast cancer risk prediction model: updates to cancer incidences, tumour pathology and web interface. Br J Cancer 110:535-45