Professor Antonis Antoniou

University of Cambridge
Department of Public Health and Primary Care
Strangeways Research Laboratory

Position: Professor
Personal home page: http://www.phpc.cam.ac.uk/people/centre-for-cancer-genetic-epidemiology-people/ccge-senior-academic-staff/dr-antonis-antoniou/

PubMed journal articles - click here

Professor Antonis Antoniou is pleased to consider applications from prospective PhD students.

Research description

My main research interest is the development and application of statistical modelling techniques for addressing clinical questions, and the development of risk prediction tools which are used in clinical practice.
I have a research group of 10 which focuses on two broad areas:
- the development and evaluation of risk prediction models for familial breast, ovarian, prostate and other cancers with a familial component;
- the identification and characterisation of cancer risks for genetically susceptible individuals, such as those carrying mutations in BRCA1, BRCA2, PALB2, RAD51C and RAD51D genes.

Research Programme
Ovarian Cancer
aca20
Recent publications:
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Key publications

Lee A, Mavaddat N, Wilcox AN, Cunningham AP, Carver T, Hartley S, Babb de Villiers C, Izquierdo A, Simard J, Schmidt MK, Walter FM, Chatterjee N, Garcia-Closas M, Tischkowitz M, Pharoah P, Easton DF, Antoniou AC.
BOADICEA: a omprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors. Genet Med. 2019 Jan 15.[Epub ahead of print] PMID: 643217

Kuchenbaecker KB, Hopper JL, Barnes DR, Phillips KA, Mooij TM, Roos-Blom MJ, Jervis S, van Leeuwen FE, Milne RL, Andrieu N, Goldgar DE, Terry MB, Rookus MA, Easton DF, Antoniou AC; BRCA1 and BRCA2 Cohort Consortium, McGuffog L, Evans DG, Barrowdale D, Frost D, Adlard J, Ong KR, Izatt L, Tischkowitz M, Eeles R, Davidson R, Hodgson S, Ellis S, Nogues C, Lasset C, Stoppa-Lyonnet D, Fricker JP, Faivre L, Berthet P, Hooning MJ, van der Kolk LE, Kets CM, Adank MA, John EM, Chung WK, Andrulis IL, Southey M, Daly MB, Buys SS, Osorio A, Engel C, Kast K, Schmutzler RK, Caldes T, Jakubowska A, Simard J, Friedlander ML, McLachlan SA, Machackova E, Foretova L, Tan YY, Singer CF, Olah E, Gerdes AM, Arver B, Olsson H.
Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers JAMA. 2017 Jun 20;317(23):2402-2416. doi: 10.1001/jama.2017.7112. PMID: 28632866

Nyberg T, Govindasami K, Leslie G, Dadaev T, Bancroft E, Ni Raghallaigh H, Brook MN, Hussain N, Keating D, Lee A, McMahon R, Morgan A, Mullen A, Osborne A, Rageevakumar R; UK Genetic Prostate Cancer Study Collaborators, Kote-Jarai Z, Eeles R, Antoniou AC. Homeobox B13 G84E Mutation and Prostate Cancer Risk Eur Urol. 2019 May;75(5):834-845. doi: 10.1016/j.eururo.2018.11.015. Epub 2018 Dec 8. PMID: 30527799

Phelan CM, Kuchenbaecker KB… Chenevix-Trench G, Goode EL, Sellers TA, Gayther SA, Antoniou AC, Pharoah PDP P (2017)
Identification of twelve new susceptibility loci for different histotypes of epithelial ovarian cancer Nat Genet. 2017 May; 49(5):680-691. doi: 10.1038/ng.3826. Epub 2017 Mar 27.PMID: 28346442

Milne, R.L., Kuchenbaecker, K.B., Michailidou, K …Antoniou AC.*, Simard J. (2017)
Identification of ten variants associated with risk of estrogen receptor negative breast cancer. *Joint senior author Nat Genet. 2017 Dec;49(12):1767-1778. doi: 10.1038/ng.3785. Epub 2017 Oct 23. PMID: 29058716

Kuchenbaecker KB, McGuffog L, Barrowdale D, Lee A, Soucy P, Dennis J, Domchek SM, Robson M, Spurdle AB, Ramus SJ, Mavaddat N, Terry MB, Neuhausen SL, Schmutzler RK, Simard J, Pharoah PDP, Offit K, Couch FJ, Chenevix-Trench G, Easton DF, Antoniou AC.
Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers J Natl Cancer Inst. 2017 Jul 1;109(7). doi: 10.1093/jnci/djw302. PMID: 28376175

Antoniou, A.C., Foulkes, W.D., and Tischkowitz, M. (2014). Breast-cancer risk in families with mutations in PALB2. N Engl J Med 371, 1651-1652 PMID: 25337756

Antoniou AC, Cunningham AP, Peto J, Evans DG, Lalloo F, Narod SA, Risch HA, Eyfjord JE, Hopper JL, Southey MC, Olsson H, Johannsson O, Borg A, Pasini B, Radice P, Manoukian S, Eccles DM, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tryggvadottir L, Syrjakoski K, Kallioniemi OP, Eerola H, Nevanlinna H, Pharoah PD, Easton DF.
The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
Br J Cancer. 2008 Apr 22;98(8):1457-66. doi: 10.1038/sj.bjc.6604305. Epub 2008 Mar 18.PMID: 18349832