Professor Adrian Liston

University departments
Department of Pathology

Position: Professor
Personal home page:

PubMed journal articles - click here

Professor Adrian Liston is pleased to consider applications from prospective PhD students.

Research description

We are focussed on understanding the biology of regulatory T cells within the tissues. How they migrate there, what controls their numbers and their functions, both immunological and tissue homeostatic in nature. Our approach is to identify key unknowns and then design new genetic tools to answer them.

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Secondary Programme
Pancreatic Cancer
Methods and technologies
Model organisms
Tumour type interests
Recent publications:
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Key publications

Van Nieuwenhove, Lagou, Van Eyck, Dooley, Bodenhofer, Roca, Vandebergh, Goris, Humblet-Baron, Wouters and Liston. ‘Machine learning identifies an immunological pattern associated with multiple juvenile idiopathic arthritis subtypes’. 2019. Annals of the Rheumatic Diseases. 78(5) p617. (IF=12.4)

Humblet-Baron, Franckaert, Dooley, Ailal, Bousfiha, Deswarte, Oleaga-Quintas, Casanova, Bustamante and Liston. ‘IFN-γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis’. 2019. Journal of Allergy and Clinical Immunology. In press. (IF=13.1)

Schlenner, Pasciuto, Lagou, Burton, Prezzemolo, Junius, Roca, Seillet, Louis, Dooley, Luong, Van Nieuwenhove, Wicks, Belz, Humblet-Baron, Wouters and Liston. ‘NFIL3 mutations alter immune homeostasis and sensitise for arthritis pathology’. 2019. Annals of the Rheumatic Diseases. 78(3) p342. (IF=12.4)

Liston and Masters. ‘Homeostasis-altering molecular processes as mechanisms of inflammasome activation’. Nature Reviews Immunology. 2017. 17(3) p208. (IF=43)

Carr, Dooley, Garcia-Perez, Lagou, Lee, Wouters, Meyts, Goris, Boeckxstaens, Linterman and Liston. ‘The cellular composition of the human immune system is shaped by age and cohabitation’. Nature Immunology. 2016. 17(4) p461. (IF=20)

Dooley, Tian, Schonefeldt, Delghingaro-Augusto, Garcia-Perez, Pascuito, Di Marino, Carr, Oskolkov, Lyssenko, Franckaert, Lagou, Overbergh, Vandenbussche, Allemeersch, Chabot-Roy, Dahlstrom, Laybutt, Petrovsky, Socha, Gevaert, Jetten, Lambrechts, Linterman, Goodnow, Nolan, Lesage, Schlenner and Liston. ‘Genetic predisposition for beta cell fagility underlies type 1 and type 2 diabetes’. Nature Genetics. 2016. 48(5) p519. (IF=29)

Masters, Lagou, Jeru, Baker, Van Eyck, Parry, Lawless, De Nardo, Garcia-Perez, Dagley, Holley, Dooley, Moghaddas, Pascuito, Jeandel, Sciot, Lyras, Webb, Nicholson, De Somer, van Nieuwenhove, Ruuth-Praz, Copin, Cochet, Medlej-Hashim, Megarbane, Schroder, Savic, Goris, Amselem, Wouters and Liston. ‘Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.’ Science Translational Medicine. 2016. 8(332) p45. (IF=16)

Liston and Gray. ‘Homeostatic control of regulatory T cell diversity’. 2014. Nature Reviews Immunology. 14(3):154. (IF=33.1)

Pierson, Cauwe, Policheni, Schlenner, Franckaert, Berges, Humblet-Baron, Schonefeldt, Herold, Hildeman, Strasser, Bouillet, Lu, Matthys, Freitas, Luther, Weaver, Dooley, Gray and Liston. ‘Anti-apoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells.’ 2013. Nature Immunology. 14(9) p959. (IF=26.2)

Papadopoulou, Dooley, Linterman, Pierson, Ucar, Kyewski, Zuklys, Hollander, Matthys, Gray, De Strooper and Liston. 'The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.' 2012. Nature Immunology. 13 p181. (IF=26.2)

Linterman, Pierson, Lee, Kallies, Kawamoto, Rayner, Srivastava, Divekar, Beaton, Hogan, Fagarasan, Liston*, Smith* and Vinuesa*. *Co-last. 'Follicular regulatory T cells develop from FoxP3+ T cells and control T follicular helper cells and the germinal center response'. 2011. Nature Medicine. 17(8) p975. (IF=22.9)

Liston, Enders and Siggs. ‘Unravelling the clinical association of partial T-cell immunodeficiency and immune dysregulation with mouse models’ 2008. Nature Reviews Immunology. 8(7) p545. (IF=33.1)

Siggs, Miosge, Yates, Kuchsarka, Sheahan, Brdicka, Weiss, Liston* and Goodnow*. ‘Opposing functions of Zap70 for immunity and tolerance titrate differentially in response to inherited single nucleotide substitutions’. 2007. Immunity. 27(6) p912. *equal contribution senior authors. (IF=21.5)

Liston, Lesage, Gray, O’Reilly, Strasser, Fahrer, Boyd, Wilson, Baxter, Gallo, Crabtree, Peng, Wilson and Goodnow. ‘Generalised resistance to thymic deletion in the NOD mouse: a polygenic trait characterized by defective induction of Bim’. 2004. Immunity 21(6) p817. (IF=21.5)