Dr Tony Jackson

University of Cambridge

University departments
Department of Biochemistry

Position: Senior Lecturer
Personal home page: http://www.bioc.cam.ac.uk/people/uto/jacksont

PubMed journal articles - click here

Dr Tony Jackson is pleased to consider applications from prospective PhD students.

Research description

Proteomic approaches to plasma-membrane assemblies: Membrane proteins cluster together selectively as spatially-restricted, functionally integrated complexes. This can play an important role in many biological processes, including signal transduction. We have developed a proteomic method to identify such proteins. We believe that our method will have wide application to many problems in the biomolecular sciences.

Research Programme or Virtual Institute
Fundamental Biology of Cancer
Methods and technologies
Cell culture
Protein biochemistry
X-ray crystallography
Tumour type interests

Cell biology Proteomics ion channels membrane traffic

Recent publications:
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Key publications

1. Li, X. W., Rees, J. S., Xue, P., Zhang, H., Hamaia, S. W., Sanderson, B., Funk, P. E., Farndale, R. W., Lilley, K. S., Perrett, S., and Jackson, A. P. (2014) New Insights into the DT40 B-Cell Receptor Cluster using a Proteomic Proximity Labeling Assay. J Biol Chem 289, 14434-1447 2. Namadurai, S., Balasuriya, D., Rajappa, R., Wiemhofer, M., Stott, K., Klingauf, J., Edwardson, J. M., Chirgadze, D. Y., and Jackson, A. P. (2014) Crystal Structure and Molecular Imaging of the Nav Channel beta3 Subunit Indicates a Trimeric Assembly. J Biol Chem 289, 10797-10811 3. Yereddi, N. R., Cusdin, F. S., Namadurai, S., Packman, L. C., Monie, T. P., Slavny, P., Clare, J. J., Powell, A. J., and Jackson, A. P. (2013) The immunoglobulin domain of the sodium channel beta3 subunit contains a surface-localized disulfide bond that is required for homophilic binding. FASEB J 27, 568-580 4. Cusdin, F. S., Nietlispach, D., Maman, J., Dale, T. J., Powell, A. J., Clare, J. J., and Jackson, A. P. (2010) The sodium channel beta3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions. J Biol Chem 285, 33404-33412 5. Merrick, E. C., Kalmar, C. L., Snyder, S. L., Cusdin, F. S., Yu, E. J., Sando, J. J., Isakson, B. E., Jackson, A. P., and Patel, M. K. (2010) The importance of serine 161 in the sodium channel beta3 subunit for modulation of Na(V)1.2 gating. Pflugers Arch 460, 743-753 6. Hakim, P., Brice, N., Thresher, R., Lawrence, J., Zhang, Y., Jackson, A. P., Grace, A. A., and Huang, C. L. (2010) Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties. Acta Physiol (Oxf) 198, 47-59 7. Neumann-Staubitz, P., Hall, S. L., Kuo, J., and Jackson, A. P. (2010) Characterization of a temperature-sensitive vertebrate clathrin heavy chain mutant as a tool to study clathrin-dependent events in vivo. PLoS One 5, e12017 8. Zhang, C., Jackson, A. P., Zhang, Z. R., Han, Y., Yu, S., He, R. Q., and Perrett, S. (2010) Amyloid-like aggregates of the yeast prion protein ure2 enter vertebrate cells by specific endocytotic pathways and induce apoptosis. PLoS One 5, e12529 9. Hall, S. L., Hester, S., Griffin, J. L., Lilley, K. S., and Jackson, A. P. (2009) The organelle proteome of the DT40 lymphocyte cell line. Mol Cell Proteomics 8, 1295-1305 10. Cusdin, F. S., Clare, J. J., and Jackson, A. P. (2008) Trafficking and cellular distribution of voltage-gated sodium channels. Traffic 9, 17-26