We are interested in better understanding the biological processes that contribute to renal cancer development and progression by developing clinically relevant mouse models of the disease. The lab is employing a number of candidate gene and unbiased mutagenesis approaches to genetically modify the mouse renal apithelium and replicate the genetic events observed in human renal cell carcinoma. The development of reproducible and accurate RCC mouse models will allow in-vivo investigations of the underlying tumour biology and the discovery of new methodologies for the detection, management and treatment of human cancer.